Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study.

abstract：:A progressive rise of oxidative stress due to altered reduction-oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in physiology and pathophysiology. Reactive oxygen species and reactive nitrogen species serve as signaling messengers for the evolution and...

journal_title：Critical care (London, England)

authors： Haddad JJ

更新日期：2003-02-01 00:00:00

abstract：:Acute pancreatitis results from a sequence of events that involve the systemic inflammatory response. Activated C has multiple anti-inflammatory activities and may attenuate the degree of pancreatic injury and systemic organ dysfunction when infused early in pancreatitis. ...

journal_title：Critical care (London, England)

authors： Kirschenbaum L,Astiz M

更新日期：2005-06-01 00:00:00

abstract：:Over the last years, there was an increase in the number and severity of Clostridium difficile infections (CDI) in all medical settings, including the intensive care unit (ICU). The current prevalence of CDI among ICU patients is estimated at 0.4-4% and has severe impact on morbidity and mortality. An estimated 10-20%...

journal_title：Critical care (London, England)

authors： Prechter F,Katzer K,Bauer M,Stallmach A

更新日期：2017-10-22 00:00:00

abstract：INTRODUCTION:To investigate the effects of G-CSF or GM-CSF therapy in non-neutropenic patients with sepsis. METHODS:A systematic literature search of Medline, Embase and Cochrane Central Register of Controlled Trials was conducted using specific search terms. A manual review of references was also performed. Eligible ...

journal_title：Critical care (London, England)

authors： Bo L,Wang F,Zhu J,Li J,Deng X

更新日期：2011-01-01 00:00:00

abstract：:In the previous issue of Critical Care, Meybohm and colleagues provide evidence to support hypothermia as a kind of therapeutic option for patients suffering cardiac arrest. Although anesthetics had been used to induce hypothermia, sevoflurane post-conditioning fails to confer additional anti-inflammatory effects afte...

journal_title：Critical care (London, England)

authors： Zhang H

更新日期：2010-01-01 00:00:00

abstract：:The epidemiology of severe acute renal failure has dramatically changed in the past decade. Its leading cause is sepsis and the syndrome develops mostly in the intensive care unit as part of multiple organ dysfunction syndrome. After the significant improvements obtained from the mid 1970s to the mid 1990s, the past d...

journal_title：Critical care (London, England)

authors： Ronco C

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:Procalcitonin (PCT) and C-reactive protein (CRP) are established markers of infection in the general population. In contrast, several studies reported falsely increased PCT levels in patients receiving T-cell antibodies. We evaluated the validity of these markers in patients scheduled for hemopoietic stem ...

journal_title：Critical care (London, England)

authors： Brodska H,Drabek T,Malickova K,Kazda A,Vitek A,Zima T,Markova M

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Mechanically ventilated critically ill patients frequently develop ventilator-associated pneumonia (VAP), a life-threatening complication. Proposed preventive measures against VAP include, but are not restricted to, selective decontamination of the digestive tract (SDD), selective oropharyngeal decontamina...

journal_title：Critical care (London, England)

authors： Schultz MJ,Haas LE

更新日期：2011-01-01 00:00:00

abstract：:Hydrogen sulfide (H2S), a gas with the characteristic odor of rotten eggs, is known for its toxicity and as an environmental hazard, inhibition of mitochondrial respiration resulting from blockade of cytochrome c oxidase being the main toxic mechanism. Recently, however, H2S has been recognized as a signaling molecule...

journal_title：Critical care (London, England)

authors： Wagner F,Asfar P,Calzia E,Radermacher P,Szabó C

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Contrast-enhanced ultrasound (CEUS) is a new technique that might enable portable and non-invasive organ perfusion quantification at the bedside. However, it has not yet been tested in critically ill patients. We sought to establish CEUS's feasibility, safety, reproducibility and potential diagnostic value...

journal_title：Critical care (London, England)

authors： Schneider AG,Goodwin MD,Schelleman A,Bailey M,Johnson L,Bellomo R

更新日期：2013-07-12 00:00:00

abstract：:Acute hyperglycaemia has been associated with complications, prolonged intensive care unit and hospital stay, and increased mortality. We made an inventory of the prevalence and prognostic value of hyperglycaemia, and of the effects of glucose control in different groups of critically ill patients. The prevalence of h...

journal_title：Critical care (London, England)

authors： Corstjens AM,van der Horst IC,Zijlstra JG,Groeneveld AB,Zijlstra F,Tulleken JE,Ligtenberg JJ

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:In patients with severe sepsis and septic shock as cause of Intensive Care Unit (ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy initiated before ICU admission. METHODS:We conducted a prospective observational study enrolling patients admitted to the ICU with severe se...

journal_title：Critical care (London, England)

authors： Garnacho-Montero J,Gutiérrez-Pizarraya A,Escoresca-Ortega A,Fernández-Delgado E,López-Sánchez JM

更新日期：2015-08-27 00:00:00

abstract：INTRODUCTION:Following trauma and systemic inflammatory response syndrome (SIRS), the typical response is an elevation of the total complete blood count (CBC) and a reduction of the lymphocyte count. This leukocytosis typically returns to normal within 48 hours. The persistence of a leukocytosis following trauma is ass...

journal_title：Critical care (London, England)

authors： Heffernan DS,Monaghan SF,Thakkar RK,Machan JT,Cioffi WG,Ayala A

更新日期：2012-01-20 00:00:00

abstract：:In the previous issue of Critical Care, Ma and colleagues perform a meta-analysis of five randomized, clinical trials of endothelin antagonists in patients with aneurysmal subarachnoid hemorrhage. There are four trials using clazosentan and one trial with TAK-044. These studies show that endothelin plays an important ...

journal_title：Critical care (London, England)

authors： Macdonald RL

更新日期：2012-11-09 00:00:00

abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-19 remains to be elucidated. We aimed to clarify correlation of systemic inflammation with disease s...

journal_title：Critical care (London, England)

authors： Zeng Z,Yu H,Chen H,Qi W,Chen L,Chen G,Yan W,Chen T,Ning Q,Han M,Wu D

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:Effective antimicrobial treatment is key to reduce mortality associated with bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often necessary to account for pathophysiological changes or renal replacement therapy. Extracorporeal membrane oxygenation (ECMO) is increasingly bei...

journal_title：Critical care (London, England)

authors： Kühn D,Metz C,Seiler F,Wehrfritz H,Roth S,Alqudrah M,Becker A,Bracht H,Wagenpfeil S,Hoffmann M,Bals R,Hübner U,Geisel J,Lepper PM,Becker SL

更新日期：2020-11-25 00:00:00

abstract：:Postoperative outcome is mainly influenced by ventricular function. Tests designed to identify myocardial ischemia alone will fail to detect cardiac failure and are thus inadequate as a screening test for identification of cardiac risk in noncardiac surgical patients. We find that the degree of cardiac failure is the ...

journal_title：Critical care (London, England)

authors： Older P,Hall A

更新日期：2004-10-01 00:00:00

abstract：INTRODUCTION:Multiple organ dysfunction syndrome (MODS) is a common complication of sepsis in mechanically ventilated patients with acute respiratory distress syndrome, but the links between mechanical ventilation and MODS are unclear. Our goal was to determine whether a minimally injurious mechanical ventilation strat...

journal_title：Critical care (London, England)

authors： O'Mahony DS,Liles WC,Altemeier WA,Dhanireddy S,Frevert CW,Liggitt D,Martin TR,Matute-Bello G

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to determine whether the degree of fluid responsiveness in critically ill septic patients is related to baseline mixed venous oxygen saturation (SvO2) levels. We also sought to define whether fluid responsiveness would be less likely in the presence of a high SvO2 (>70%). METHODS...

journal_title：Critical care (London, England)

authors： Velissaris D,Pierrakos C,Scolletta S,De Backer D,Vincent JL

更新日期：2011-07-26 00:00:00

abstract：INTRODUCTION:Takotsubo cardiomyopathy (TCM) is a life-threatening systemic consequence early after subarachnoid hemorrhage (SAH), but precise hemodynamics and related outcome have not been studied. The purpose of this study was to investigate the TCM-induced cardiac function by transpulmonary thermodilution and its imp...

journal_title：Critical care (London, England)

authors： Mutoh T,Kazumata K,Terasaka S,Taki Y,Suzuki A,Ishikawa T

更新日期：2014-08-12 00:00:00

abstract：: ...

journal_title：Critical care (London, England)

authors： Cortegiani A,Shafer SL

更新日期：2018-11-14 00:00:00

abstract：INTRODUCTION:Improved methods to optimize drug dosing in the critically ill are urgently needed. Traditional prescribing culture involves recognition of factors that mandate dose reduction (such as renal impairment), although optimizing drug exposure, through more frequent or augmented dosing, represents an evolving st...

journal_title：Critical care (London, England)

authors： Udy AA,Roberts JA,Shorr AF,Boots RJ,Lipman J

更新日期：2013-02-28 00:00:00

abstract：INTRODUCTION:The analysis of flow and pressure waveforms generated by ventilators can be useful in the optimization of patient-ventilator interactions, notably in chronic obstructive pulmonary disease (COPD) patients. To date, however, a real clinical benefit of this approach has not been proven. METHODS:The aim of th...

journal_title：Critical care (London, England)

authors： Di Marco F,Centanni S,Bellone A,Messinesi G,Pesci A,Scala R,Perren A,Nava S

更新日期：2011-01-01 00:00:00

abstract：:Urgent cardiac ultrasound examination in the critical care setting is clinically useful. Application of goal-directed echocardiography in this setting is quite distinct from typical exploratory diagnostic comprehensive echocardiography, because the urgent critical care setting mandates a goal-directed approach. Goal-d...

journal_title：Critical care (London, England)

authors： Walley PE,Walley KR,Goodgame B,Punjabi V,Sirounis D

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Sepsis is an important cause of neonatal morbidity and mortality; therefore, the early diagnosis of neonatal sepsis is essential. METHOD:Our aim was to compare the diagnostic accuracy of procalcitonin (PCT), C-reactive protein (CRP), procalcitonin combined with C-reactive protein (PCT + CRP) and presepsin i...

journal_title：Critical care (London, England)

authors： Ruan L,Chen GY,Liu Z,Zhao Y,Xu GY,Li SF,Li CN,Chen LS,Tao Z

更新日期：2018-11-21 00:00:00

abstract：INTRODUCTION:Protocols using high levels of positive end-expiratory pressure (PEEP) in combination with low tidal volumes have been shown to reduce mortality in patients with severe acute respiratory distress syndrome (ARDS). However, the optimal method for setting PEEP is yet to be defined. It has been shown that resp...

journal_title：Critical care (London, England)

authors： Kostic P,Zannin E,Andersson Olerud M,Pompilio PP,Hedenstierna G,Pedotti A,Larsson A,Frykholm P,Dellaca RL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Microcirculatory dysfunction develops in both septic and cardiogenic shock patients, and it is associated with poor prognosis in patients with septic shock. Information on the association between microcirculatory dysfunction and prognosis in cardiogenic shock patients with venoarterial extracorporeal membran...

journal_title：Critical care (London, England)

authors： Yeh YC,Lee CT,Wang CH,Tu YK,Lai CH,Wang YC,Chao A,Huang CH,Cheng YJ,Chen YS,NTUH Center of Microcirculation Medical Research (NCMMR).

更新日期：2018-08-19 00:00:00

abstract：BACKGROUND:The lack of a patent source of infection after 24 hours of management of shock considered septic is a common and disturbing scenario. We aimed to determine the prevalence and the causes of shock with no diagnosis 24 hours after its onset, and to compare the outcomes of patients with early-confirmed septic sh...

journal_title：Critical care (London, England)

authors： Contou D,Roux D,Jochmans S,Coudroy R,Guérot E,Grimaldi D,Ricome S,Maury E,Plantefève G,Mayaux J,Mekontso Dessap A,Brun-Buisson C,de Prost N

更新日期：2016-11-06 00:00:00

abstract：INTRODUCTION:The use of human recombinant activated protein C (rhAPC) for the treatment of severe sepsis remains controversial despite multiple reported trials. The efficacy of rhAPC remains a matter of dispute. We hypothesized that patients with septic shock who were treated with rhAPC had an improved in-hospital mort...

journal_title：Critical care (London, England)

authors： Sadaka F,O'Brien J,Migneron M,Stortz J,Vanston A,Taylor RW

更新日期：2011-01-01 00:00:00

abstract：:Sepsis represents a dysregulated host response to infection, the extent of which determines the severity of organ dysfunction and subsequent outcome. All trialled immunomodulatory strategies to date have resulted in either outright failure or inconsistent degrees of success. Intravenous immunoglobulin (IVIg) therapy f...

journal_title：Critical care (London, England)

authors： Shankar-Hari M,Spencer J,Sewell WA,Rowan KM,Singer M

更新日期：2012-12-12 00:00:00