A high affinity gonadotropin-releasing hormone (GnRH) tracer, radioiodinated at position 6, facilitates analysis of mutant GnRH receptors.

abstract：:In different types of mammalian cells, insulin has been shown to promote the release of an inositol phosphate glycan (InsP-glycan) through the hydrolysis of a glycosyl-phosphatidylinositol (glycosyl-PtdIns). This InsP-glycan, which has been demonstrated to be taken up by intact cells, may mediate some of the biologica...

journal_title：Endocrinology

authors： Sánchez-Gutiérrez JC,Sánchez-Arias JA,Valle JC,Guadaño A,Samper B,Mato JM,Felíu JE

更新日期：1994-03-01 00:00:00

abstract：:Analogs of the seco-steroid hormone, 1,25-dihydroxyvitamin D3 [1,25-(OH)-2D3] can preferentially stimulate genomic or nongenomic signaling pathways in osteoblasts. In this study, we used 1,25-(OH)2D3 analogs and voltage-sensitive Ca2+ channel (VSCC) ligands, including dihydropyridines (Bay K 8644 and nitrendipine), in...

journal_title：Endocrinology

authors： Khoury R,Ridall AL,Norman AW,Farach-Carson MC

更新日期：1994-12-01 00:00:00

abstract：:To identify genes that are differentially expressed in the developing testis we used representational difference analysis of complementary DNA from gonads of mouse embryos at 13.5 days postcoitum (dpc). Three genes were identified. One of them was a novel gene termed tescalcin that encoded a putative EF-hand Ca(2+)-bi...

journal_title：Endocrinology

authors： Perera EM,Martin H,Seeherunvong T,Kos L,Hughes IA,Hawkins JR,Berkovitz GD

更新日期：2001-01-01 00:00:00

abstract：:Adult female transgenic mice expressing the human GH (hGH) gene with mouse metallothionein-I promoter are sterile. To evaluate the hypothalamic-pituitary function in these animals, adult female transgenic mice and nontransgenic normal littermates were ovariectomized. On days 7 and 8 after ovariectomy, mice were inject...

journal_title：Endocrinology

authors： Chandrashekar V,Bartke A,Wagner TE

更新日期：1992-04-01 00:00:00

abstract：:In the present study we have used a high affinity photoaffinity label (PAL) agonist (pGlu-His-Trp-Ser-125I-iodoTyr-D-Lys(para-N3-Benzoyl)-Leu-Arg-P roNHEt) and a PAL antagonist (NAcD2Nal-D4ClPhe-D3Pal-Ser-125I-iodo-NMeTyr-D-L ys(para-N3-Benzoyl)Leu-Lys(Isp) - Pro-D-Ala-NH2) to covalently label the GnRH receptor. Rat p...

journal_title：Endocrinology

authors： Janovick JA,Haviv F,Fitzpatrick TD,Conn PM

更新日期：1993-08-01 00:00:00

abstract：:In seasonally breeding species, an animal's photoperiodic history (the daylength or photoperiod previously experienced) influences the reproductive response to new photoperiods. However, this has only been examined over a relatively narrow range of photoperiods. We assessed whether Djungarian hamsters (Phodopus sungor...

journal_title：Endocrinology

authors： Rivkees SA,Hall DA,Weaver DR,Reppert SM

更新日期：1988-06-01 00:00:00

abstract：:To investigate further brain-pituitary-gonadal interrelationships we have generated mice in which the gene encoding the FSH receptor has been disrupted. Female FSH receptor knockout (FSHRKO) mice were infertile. The ovaries were significantly reduced in size, with follicular development arrested at the preantral stage...

journal_title：Endocrinology

authors： Abel MH,Wootton AN,Wilkins V,Huhtaniemi I,Knight PG,Charlton HM

更新日期：2000-05-01 00:00:00

abstract：:The distribution and density of selectively labeled mu-, delta-, and kappa-opioid binding sites were examined by in vitro radioautography in the hypothalamus of normal, estradiol valerate (EV)-injected, and estradiol (E2)-implanted female rats. Hypothalamic beta-endorphin concentration was also examined by RIA in thes...

journal_title：Endocrinology

authors： Desjardins GC,Beaudet A,Brawer JR

更新日期：1990-12-01 00:00:00

abstract：:The effects of several compounds which interfere with cellular microfilaments and microtubules on the conversion of proparathyroid hormone (ProPTH) to parathyroid hormone (PTH) were examined in slices of bovine parathyroid slices incubated in vitro with 3H-leucine. Inhibitors of microtubular function, vinblastine and ...

journal_title：Endocrinology

authors： Kemper B,Habener JF,Rich A,Potts JT Jr

更新日期：1975-04-01 00:00:00

abstract：:This study was initiated to investigate the significance of uterine cell death and proliferation during the estrous cycle and early pregnancy and their correlation with sex steroids in hamsters where blastocyst implantation occurs in only progesterone-primed uteri. The results obtained in hamsters were also compared w...

journal_title：Endocrinology

authors： Zhang Q,Paria BC

更新日期：2006-05-01 00:00:00

abstract：:The mechanisms by which bacterial endotoxin [lipopolysaccharide (LPS)] stimulates the hypothalamo-pituitary-adrenal axis (HPAA) have not been elucidated. The present study was designed to investigate the involvement of macrophages in plasma ACTH and corticosterone responses to LPS administration in rats using selectiv...

journal_title：Endocrinology

authors： Derijk R,Van Rooijen N,Tilders FJ,Besedovsky HO,Del Rey A,Berkenbosch F

更新日期：1991-07-01 00:00:00

abstract：:Livers from fed rats (180-240 g) were perfused noncyclically with a hemoglobin-free medium in vitro to determine whether vasoactive intestinal peptide (VIP) increases hepatic glucose production through a cAMP- or a Ca(2+)-dependent mechanism. Glucose output did not increase, but cAMP increased maximally during 10(-9) ...

journal_title：Endocrinology

authors： Saito K,Yamatani K,Manaka H,Takahashi K,Tominaga M,Sasaki H

更新日期：1992-04-01 00:00:00

abstract：:Age-related bone loss is an important risk factor for fractures in the elderly; it results from an imbalance in bone remodeling mainly due to decreased bone formation. We have previously demonstrated that endogenous G protein-coupled receptor (GPCR)-driven Gi signaling in osteoblasts (Obs) restrains bone formation in ...

journal_title：Endocrinology

authors： Millard SM,Wang L,Wattanachanya L,O'Carroll D,Fields AJ,Pang J,Kazakia G,Lotz JC,Nissenson RA

更新日期：2017-06-01 00:00:00

abstract：:After 5 days of incubation with 10 nM tritiated dexamethasone, the amount of glucocorticoid displaceably-bound by the ACTH-secreting, glucocorticoid-responsive AtT-20 mouse pituitary tumor cell decreases by 70-80%. This decrease takes place in both the cytosolic and nuclear fractions. Although one might predict that t...

journal_title：Endocrinology

authors： Svec F,Rudis M

更新日期：1982-08-01 00:00:00

abstract：:IL-1, secreted by human embryos and trophoblast cells, is important for successful implantation and pregnancy. We previously reported that IL-1beta induced IL-8 production in human endometrial stromal cells (ESCs) and that induction was regulated by substances implicated in implantation. In the present study using hum...

journal_title：Endocrinology

authors： Hirota Y,Osuga Y,Hasegawa A,Kodama A,Tajima T,Hamasaki K,Koga K,Yoshino O,Hirata T,Harada M,Takemura Y,Yano T,Tsutsumi O,Taketani Y

更新日期：2009-01-01 00:00:00

abstract：:Prolactin (PRL) is a vertebrate hormone with diverse actions in osmoregulation, metabolism, reproduction, and in growth and development. Osmoregulation is fundamental to maintaining the functional structure of the macromolecules that conduct the business of life. In teleost fish, PRL plays a critical role in osmoregul...

journal_title：Endocrinology

authors： Yamaguchi Y,Moriyama S,Lerner DT,Grau EG,Seale AP

更新日期：2016-09-01 00:00:00

abstract：:We have previously reported that neurotensin (NT) is released from the small intestine and elevated in the hepatic-portal circulation in response to the perfusion of the small intestine with a micellar solution of oleic acid. In order to determine the minimum acyl chain length and whether the presence of a carboxylic ...

journal_title：Endocrinology

authors： Ferris CF,Armstrong MJ,George JK,Stevens CA,Carraway RE,Leeman SE

更新日期：1985-03-01 00:00:00

abstract：:Although the neurohypophyseal hormone oxytocin (OT) is best know for its role in reproduction, OT also stimulates natriuresis at physiological plasma levels. This effect is mediated via specific renal OT receptors (OTRs). In the present study, we have characterized rat renal OTR gene transcripts and assessed their reg...

journal_title：Endocrinology

authors： Breton C,Neculcea J,Zingg HH

更新日期：1996-07-01 00:00:00

abstract：:Amphibian skin has functional characteristics of epithelium in the mammalian distal nephron and plays an important role in sodium and water metabolism in these animals. A peptide extracted from the skin of the Australian frog Crinia georgiana has been purified, has been determined to have the amino acid sequence of [A...

journal_title：Endocrinology

authors： Siragy H,Howell N,Rose CE Jr,Khosla MC,Peach MJ,Carey RM

更新日期：1988-01-01 00:00:00

abstract：:Dipeptyl peptidase-4 (DPP-4) inhibitors modulate the progression of atherosclerosis. To gain insights into their mechanism of action, 9-wk-old male apolipoprotein E (apoE)-deficient mice were fed a DPP-4 inhibitor, anagliptin-containing diet. The effects of anagliptin were investigated in, a monocyte cell line, human ...

journal_title：Endocrinology

authors： Ervinna N,Mita T,Yasunari E,Azuma K,Tanaka R,Fujimura S,Sukmawati D,Nomiyama T,Kanazawa A,Kawamori R,Fujitani Y,Watada H

更新日期：2013-03-01 00:00:00

abstract：:Mammary gland is an organ that undergoes cycles of growth, differentiation, and function during pregnancy and lactation. Although it is known that the gland enhances its sensitivity to insulin during lactation, it remains to be investigated whether this increased sensitivity develops during pregnancy and which are the...

journal_title：Endocrinology

authors： Carrascosa JM,Ramos P,Molero JC,Herrera E

更新日期：1998-02-01 00:00:00

abstract：:Insulin-like growth factor (IGF) I, a polypeptide synthesized by skeletal cells, and its amino terminus truncated derivative desamino-(1-3)-IGF I (des-IGF I) were compared for their effects on bone formation in vitro. Des-IGF I and IGF I were studied for their effects on DNA and collagen synthesis in cultures of intac...

journal_title：Endocrinology

authors： Canalis E,McCarthy TL,Centrella M

更新日期：1991-07-01 00:00:00

abstract：:19-Nor progesterone (19-nor P) has previously been shown to have a approximately 3-fold higher affinity for mineralocorticoid receptors than progesterone (P), its C-19 methylated parent steroid; in contrast, 19-nor aldosterone has less than 1% the mineralocorticoid receptor affinity of aldosterone. In the present stud...

journal_title：Endocrinology

authors： Funder JW,Adam WR

更新日期：1981-07-01 00:00:00

abstract：:Within the preoptic region, nitric oxide (NO) production varies during the ovarian cycle and has the ability to impact hypothalamic reproductive function. One mechanism for the regulation of NO release mediated by estrogens during the estrous cycle includes physical association of the calcium-activated neuronal NO syn...

journal_title：Endocrinology

authors： Parkash J,d'Anglemont de Tassigny X,Bellefontaine N,Campagne C,Mazure D,Buée-Scherrer V,Prevot V

更新日期：2010-06-01 00:00:00

abstract：:Recent studies from our laboratory indicate that high density lipoproteins (HDL) and apolipoproteins-AI, -AII, and -CI stimulate the release of human placental lactogen (hPL) from human placental explants and trophoblast cells. However, the intracellular mechanisms by which HDL stimulate hPL release are unknown. Since...

journal_title：Endocrinology

authors： Wu YQ,Jorgensen EV,Handwerger S

更新日期：1988-10-01 00:00:00

abstract：:To analyze the molecular origin of an ER variant, the truncated ER product-1, transiently expressed at the proestrus in lactotrope cells, we generated a 2.5-kb sequence of a genomic region upstream and downstream the specific sequence truncated ER product-1. Genomic Southern blot analysis showed that truncated ER prod...

journal_title：Endocrinology

authors： Tiffoche C,Vaillant C,Schausi D,Thieulant ML

更新日期：2001-09-01 00:00:00

abstract：:The rat uterine enzyme glycerylphosphorylcholine (GPC) diesterase found in the proestrous secretions was purified and characterized biochemically with respect to its subunit mol wt, native size, pI, and amino acid and carbohydrate composition. The 30-kDa protein was assessed to have a native mol wt of 105 kDa, as dete...

journal_title：Endocrinology

authors： Mitra J,Chowdhury M

更新日期：1991-09-01 00:00:00

abstract：:The present study was conducted to elucidate the possible molecular mechanisms involved in the antispermatogenic activity of l-CDB-4022, an indenopyridine. In this study 45-d-old male Sprague-Dawley rats were treated with a single oral dose of l-CDB-4022 (2.5 mg/kg) or vehicle, and blood and testes were collected at v...

journal_title：Endocrinology

authors： Koduri S,Hild SA,Pessaint L,Reel JR,Attardi BJ

更新日期：2008-04-01 00:00:00

abstract：:We describe a new animal model of obesity and GH deficiency and report the effects on body fat of administering (GH) and insulin-like growth factor (IGF-I) in the model. Female GH-deficient dwarf rats fed a high-fat diet became obese and insulin-resistant compared with chow-fed controls. They were treated with recombi...

journal_title：Endocrinology

authors： Clark RG,Mortensen DL,Carlsson LM,Carlsson B,Carmignac D,Robinson IC

更新日期：1996-05-01 00:00:00

abstract：:We evaluated the capacity of estradiol (E(2)) to regulate PTHrP production, cell growth, tumor growth, and metastasis to the skeleton in breast cancer. In estrogen receptor (ER)-negative human breast cancer cells, MDA-MB-231, and cells transfected with full-length cDNA encoding ER (S-30), E(2) caused a marked decrease...

journal_title：Endocrinology

authors： Rabbani SA,Khalili P,Arakelian A,Pizzi H,Chen G,Goltzman D

更新日期：2005-07-01 00:00:00