Abstract:
:Mitomycin C-induced sister chromatic exchange and quadriradial formation were studied in chromosomes from Muntiacus muntjac fibroblasts and A9, a transformed mouse cell line. We present the first direct cytological evidence for the induction of true somatic recombination involving homologous chromosomes. Analysis of the quadriradials from Muntjac cells indicates a non-random distribution with respect to the chromosomes involved and with respect to the points of conjunction. Sister chromatid exchange and quadriradial formation may reflect the outcome of repair processes involving a high frequency of homologous exchanges in the interphase nucleus.
journal_name
Chromosomajournal_title
Chromosomaauthors
Huttner KM,Ruddle FHdoi
10.1007/BF00293724subject
Has Abstractpub_date
1976-06-30 00:00:00pages
1-13issue
1eissn
0009-5915issn
1432-0886journal_volume
56pub_type
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