Eubacterial sigma-factors.

Abstract:

:The initiation of transcription is the most important step for gene regulation in eubacteria. To initiate transcription, RNA polymerase has to associate with a small protein, known as a sigma-factor. The sigma-factor directs RNA polymerase to a specific class of promoter sequences. Most bacterial species synthesize several different sigma-factors that recognize different consensus sequences. This variety in sigma-factors provides bacteria with the opportunity to maintain basal gene expression as well as for regulation of gene expression in response to altered environmental or developmental signals. This review focuses on the function, regulation and distribution of the 14 different classes of sigma-factors that are presently known.

journal_name

FEMS Microbiol Rev

authors

Wösten MM

doi

10.1111/j.1574-6976.1998.tb00364.x

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

127-50

issue

3

eissn

0168-6445

issn

1574-6976

pii

S0168-6445(98)00011-4

journal_volume

22

pub_type

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