Predictive value of aminotransferase and hepatitis B virus DNA levels on response to interferon therapy for chronic hepatitis B.

abstract：:We compared Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+ -M2BP) levels between patients with chronic hepatitis B (n=249) and chronic hepatitis C (n=386) based on the degree of liver fibrosis. We examined WFA+ -M2BP levels in patients with F4 (cirrhosis), F3 or more (advanced fibrosis) and F2 or ...

journal_title：Journal of viral hepatitis

authors： Nishikawa H,Enomoto H,Iwata Y,Kishino K,Shimono Y,Hasegawa K,Nakano C,Takata R,Nishimura T,Yoh K,Ishii A,Aizawa N,Sakai Y,Ikeda N,Takashima T,Iijima H,Nishiguchi S

更新日期：2016-12-01 00:00:00

abstract：:This study estimated latent classes (ie, unobserved subgroups in a population) of people who use drugs in Vancouver, Canada, and examined how these classes relate to phylogenetic clustering of hepatitis C virus (HCV) infection. HCV antibody-positive people who use drugs from two cohorts in Vancouver, Canada (1996-2012...

journal_title：Journal of viral hepatitis

authors： Jacka B,Bray BC,Applegate TL,Marshall BDL,Lima VD,Hayashi K,DeBeck K,Raghwani J,Harrigan PR,Krajden M,Montaner JSG,Grebely J Senior

更新日期：2018-01-01 00:00:00

abstract：:GS-9857, an inhibitor of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A, demonstrates potent activity against HCV genotypes 1-6 and improved coverage against commonly encountered NS3 resistance-associated variants (RAVs). In this study, the safety, tolerability, antiviral activity and pharmacokinetics (PK...

journal_title：Journal of viral hepatitis

authors： Rodriguez-Torres M,Glass S,Hill J,Freilich B,Hassman D,Di Bisceglie AM,Taylor JG,Kirby BJ,Dvory-Sobol H,Yang JC,An D,Stamm LM,Brainard DM,Kim S,Krefetz D,Smith W,Marbury T,Lawitz E

更新日期：2016-08-01 00:00:00

abstract：:Dendritic cells (DCs) in chronic hepatitis C patients display impaired function, although the details remain unclear. To investigate the hepatitis C virus (HCV) protein that has the most impact on DC function, we compared five recombinant proteins and seven HCV protein genes in modulating DC phenotype and function. Im...

journal_title：Journal of viral hepatitis

authors： Takaki A,Tatsukawa M,Iwasaki Y,Koike K,Noguchi Y,Shiraha H,Sakaguchi K,Nakayama E,Yamamoto K

更新日期：2010-08-01 00:00:00

abstract：:Sequence motifs within the non-structural protein NS5 or NS5B of the members of the family Flaviviridae suggest that this protein is the RNA-dependent RNA polymerase. This protein has now been expressed in various in vitro systems and used in polymerase assays. To understand the role of the RNA polymerase in RNA repli...

journal_title：Journal of viral hepatitis

authors： Bartholomeusz A,Thompson P

更新日期：1999-07-01 00:00:00

abstract：:Herpes simplex virus (HSV) hepatitis is a rare and potential life-threatening disease. The diagnosis of HSV hepatitis is hampered by its indifferent clinical presentation, which necessitates confirmatory laboratory data to identify HSV in the affected liver. However, liver biopsies are often contraindicated in the con...

journal_title：Journal of viral hepatitis

authors： Beersma MF,Verjans GM,Metselaar HJ,Osterhaus AD,Berrington WR,van Doornum GJ

更新日期：2011-04-01 00:00:00

abstract：:The establishment of an in vitro system for hepatitis C virus (HCV) propagation is essential to characterize virus replication, virus persistence and viral pathogenicity. The aim was to establish HCV replication in HepG2 cells by gene transfer of infectious HCV cDNA. First, several gene transfer methods were evaluated...

journal_title：Journal of viral hepatitis

authors： Hiramatsu N,Dash S,Gerber MA

更新日期：1997-01-01 00:00:00

abstract：:The human La (hLa) protein functions in RNA metabolism and is activated by casein kinase 2 (CK2) phosphorylation. Hepatitis B virus (HBV) can exploit hLa to stabilize its RNA and promote its pathogenesis. To enhance our knowledge of host molecular pathways involved in HBV pathogenesis, a bioinformatic approach was use...

journal_title：Journal of viral hepatitis

authors： Tang J,Zhang ZH,Liu GL

更新日期：2013-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common complication of HCV infection leading to liver transplantation. We evaluated the impact of aetiology of liver disease on patient and graft survival following liver transplantation for HCC. From the Scientific Registry of Transplant Recipients (2002-2011), all adults wh...

journal_title：Journal of viral hepatitis

authors： Younossi ZM,Stepanova M,Saab S,Ahmed A,Lam B,Srishord M,Venkatesan C,Wai H,Henry L

更新日期：2016-01-01 00:00:00

abstract：:To test the concept that off-therapy hepatitis flares with increasing qHBsAg require immediate re-treatment whereas re-treatment can be held or not necessary for those with decreasing qHBsAg, pre-retreatment combined HBsAg/ALT kinetics were classified in 22 patients with severe hepatitis flare (ALT > 30X ULN) and chec...

journal_title：Journal of viral hepatitis

authors： Chien RN,Liaw YF

更新日期：2020-05-01 00:00:00

abstract：:The efficacy of lamivudine re-treatment in chronic hepatitis B (CHB) patients who relapse after HBeAg seroconversion with lamivudine has not been investigated. The aim of this study was to evaluate the efficacy of lamivudine re-treatment in relapsed patients. Among 192 patients who had achieved HBeAg seroconversion wi...

journal_title：Journal of viral hepatitis

authors： Shin JW,Park NH,Park JH,Park JH,Jeong ID,Bang SJ,Joo KR,Kim DH

更新日期：2005-07-01 00:00:00

abstract：:There are few extant studies on the prevalence of HBV infection in couples preparing for pregnancy. We assessed the prevalence of hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in couples preparing for pregnancy in rural China, and the association between HBV prevalence and the statuses of HBsAg...

journal_title：Journal of viral hepatitis

authors： Liu J,Zhang S,Wang Q,Shen H,Zhang M,Zhang Y,Yan D,Liu M

更新日期：2017-08-01 00:00:00

abstract：:Ultrasound-based elastography and serum indexes have been individually validated as noninvasive methods for staging liver fibrosis in chronic viral hepatitis. We aimed to compare the accuracy of transient elastography (TE), shear wave elastography (SWE), aspartate aminotransferase to platelet index (APRI) and Fibrosis...

journal_title：Journal of viral hepatitis

authors： Udompap P,Sukonrut K,Suvannarerg V,Pongpaibul A,Charatcharoenwitthaya P

更新日期：2020-04-01 00:00:00

abstract：:This study investigated the molecular and pharmacokinetic mechanisms of the enhanced antiviral efficacy associated with pegylated interferon (PEG-IFN) alpha-2b and ribavirin. The study involved comparing the expression of serial double-stranded RNA-activated protein kinase (PKR) before and during treatment in 26 PEG-I...

journal_title：Journal of viral hepatitis

authors： Asahina Y,Izumi N,Umeda N,Hosokawa T,Ueda K,Doi F,Tsuchiya K,Nakanishi H,Matsunaga K,Kitamura T,Kurosaki M,Uchihara M,Higaki M,Miyake S

更新日期：2007-06-01 00:00:00

abstract：:The availability of effective, simple, well-tolerated oral direct-acting antiviral (DAA) hepatitis C regimens has raised optimism for hepatitis C virus (HCV) elimination at the population level. HCV reinfection in key populations such as people who inject drugs (PWID) and HIV-infected men who have sex with men (MSM) h...

journal_title：Journal of viral hepatitis

authors： Falade-Nwulia O,Sulkowski MS,Merkow A,Latkin C,Mehta SH

更新日期：2018-03-01 00:00:00

abstract：:Triple therapy with telaprevir, pegylated interferon and ribavirin has been reported to improve antiviral efficacy but have potentially severe adverse effects in patients with chronic hepatitis C. To avoid the severe effects of telaprevir, lowering the dose has been suggested. However, impact of dosage changes on anti...

journal_title：Journal of viral hepatitis

authors： Oze T,Hiramatsu N,Yakushijin T,Yamada R,Harada N,Morishita N,Oshita M,Mita E,Ito T,Inui Y,Inada M,Tamura S,Yoshihara H,Imai Y,Kato M,Miyagi T,Yoshida Y,Tatsumi T,Kasahara A,Hayashi N,Takehara T

更新日期：2015-03-01 00:00:00

abstract：:The role of hepatitis C virus (HCV) heterogeneity in the severity of chronic hepatitis C infection remains unclear. Our aim was to study the hypervariable region 1 (HVR1) heterogeneity in patients with chronic hepatitis C infected with genotype 1b or 3 and with normal or abnormal alanine aminotransferase (ALT). HVR1 q...

journal_title：Journal of viral hepatitis

authors： Asselah T,Martinot M,Cazals-Hatem D,Boyer N,Auperin A,Le Breton V,Erlinger S,Degott C,Valla D,Marcellin P

更新日期：2002-01-01 00:00:00

abstract：:We aimed to assess fibrosis with liver stiffness measurement long-term after sustained virological response of chronic hepatitis C and to identify risk factors associated with persisting fibrosis. In this cross-sectional study, patients with chronic hepatitis C and pretreatment advanced fibrosis or cirrhosis treated s...

journal_title：Journal of viral hepatitis

authors： Hedenstierna M,Nangarhari A,El-Sabini A,Weiland O,Aleman S

更新日期：2018-07-01 00:00:00

abstract：:To achieve WHO hepatitis C virus (HCV) elimination targets by 2030, mathematical models suggest there needs to be significant scale-up of treatment among people who inject drugs (PWID). We tested whether people who actively inject drugs can be recruited and treated successfully through a community needle and syringe p...

journal_title：Journal of viral hepatitis

authors： Schulkind J,Stephens B,Ahmad F,Johnston L,Hutchinson S,Thain D,Ward Z,Vickerman P,Hickman M,Dillon JF

更新日期：2019-05-01 00:00:00

abstract：:Hepatitis C (HCV) infection can cause cirrhosis, liver cancer and death in the absence of treatment. Many people living in the UK but born overseas are believed to be infected with HCV although many are unlikely to know they are infected. The aim of this study is to assess the potential for a case-finding approach to ...

journal_title：Journal of viral hepatitis

authors： Miners AH,Martin NK,Ghosh A,Hickman M,Vickerman P

更新日期：2014-01-01 00:00:00

abstract：:In chronic hepatitis C, transient elastography (TE) accurately identifies cirrhosis, but its ability to assess significant fibrosis (Metavir > or = F2) is variable. Constitutional and liver disease-related factors may influence TE and here we examined the variables associated with differences. Three hundred consecutiv...

journal_title：Journal of viral hepatitis

authors： Calvaruso V,Cammà C,Di Marco V,Maimone S,Bronte F,Enea M,Dardanoni V,Manousou P,Pleguezuelo M,Xirouchakis E,Attanasio M,Dusheiko G,Burroughs AK,Craxì A

更新日期：2010-07-01 00:00:00

abstract：:Long-term functional outcomes of sofosbuvir-based antiviral treatment were evaluated in a cohort study involving 16 Italian centres within the international compassionate use programme for post-transplant hepatitis C virus (HCV) recurrence. Seventy-three patients with cirrhosis (n=52) or fibrosing cholestatic hepatiti...

journal_title：Journal of viral hepatitis

authors： Vukotic R,Conti F,Fagiuoli S,Morelli MC,Pasulo L,Colpani M,Foschi FG,Berardi S,Pianta P,Mangano M,Donato MF,Malinverno F,Monico S,Tamè M,Mazzella G,Belli LS,Viganò R,Carrai P,Burra P,Russo FP,Lenci I,Toniutto P

更新日期：2017-10-01 00:00:00

abstract：:Only in a minority of patients with chronic hepatitis B (CHB) will treatment with interferon (IFN)-alpha or nucleoside analogues lead to sustained virological response. In vivo immunization (IVI) following virus suppression aims to optimize conditions for an effective immune response: following rapid and profound viru...

journal_title：Journal of viral hepatitis

authors： Sprengers D,van der Molen RG,Binda R,Kusters JG,de Man RA,Niesters HG,Schalm SW,Janssen HL

更新日期：2007-10-01 00:00:00

abstract：:Interferon (IFN)-alpha is a family of antiviral proteins encoded by different genes. The biological significance of the existence of various IFN-alpha subtypes is not clear. We have investigated the interferon system in chronic hepatitis C virus (HCV) infection, a disease that responds to interferon-alpha2 therapy in ...

journal_title：Journal of viral hepatitis

authors： Larrea E,Alberdi A,Castelruiz Y,Boya P,Civeira MP,Prieto J

更新日期：2001-03-01 00:00:00

abstract：:Viral load reduction facilitates recovery of antiviral T-cell responses. Dynamic alterations in intrahepatic viraemia clearance and immune cell reactivity during the early phase of nucleoside analogue (NA) therapy and the impact of these changes on HBeAg seroconversion are unknown. Fifteen HBeAg-positive chronic hepat...

journal_title：Journal of viral hepatitis

authors： Zheng Q,Zhu YY,Chen J,Liu YR,You J,Dong J,Zeng DW,Gao LY,Chen LH,Jiang JJ

更新日期：2014-12-01 00:00:00

abstract：:Chronic hepatitis B (CHB) is characterized by an impaired immune response to hepatitis B virus. Among the nucleos(t)ides used in CHB treatment, telbivudine is associated with the highest rates of hepatitis B e antigen (HBeAg) seroconversion rates, which are similar to those observed with pegylated interferon (PegIFN)....

journal_title：Journal of viral hepatitis

authors： Wang GQ,Ding YP,Dong YH

更新日期：2013-04-01 00:00:00

abstract：:Peginterferon alpha-2a (40 kDa) plus ribavirin is effective at achieving sustained viral response compared with no treatment in patients with chronic hepatitis C (CHC) and persistently normal aminotransferase levels (PNALT). The cost-effectiveness of treating CHC in the setting of PNALT has not been assessed. Disease ...

journal_title：Journal of viral hepatitis

authors： Hornberger J,Farci P,Prati D,Zeuzem S,Green J,Patel KK

更新日期：2006-06-01 00:00:00

abstract：:The World Health Organization has set the goal of reducing the hepatitis-related mortality rate by 65% between 2015 and 2030. Diagnosis and awareness of infection is the first essential step towards achieving this goal. Our study examined the current awareness rate of chronic viral hepatitis in the United States and t...

journal_title：Journal of viral hepatitis

authors： Kim HS,Yang JD,El-Serag HB,Kanwal F

更新日期：2019-05-01 00:00:00

abstract：:Antiviral therapy has been shown to improve the prognosis of hepatitis B virus (HBV) DNA-positive hepatocellular carcinoma (HCC) after radical treatment, but antiviral treatments require further optimization. This study aimed to evaluate the efficacies of different antiviral strategies with HCC patients after hepatect...

journal_title：Journal of viral hepatitis

authors： Qi W,Zhang Q,Xu Y,Wang X,Yu F,Zhang Y,Zhao P,Guo H,Zhou C,Wang Z,Sun Y,Liu L,Xuan W,Wang J

更新日期：2020-04-01 00:00:00

abstract：:Despite the availability of effective direct-acting antiviral (DAA) treatments for Hepatitis C virus (HCV) infection, many people remain undiagnosed and untreated. We assessed the cost-effectiveness of a Médecins Sans Frontières (MSF) HCV screening and treatment programme within a primary health clinic in Karachi, Pak...

journal_title：Journal of viral hepatitis

authors： Mafirakureva N,Lim AG,Khalid GG,Aslam K,Campbell L,Zahid H,Van den Bergh R,Falq G,Fortas C,Wailly Y,Auat R,Donchuk D,Loarec A,Coast J,Vickerman P,Walker JG

更新日期：2021-02-01 00:00:00