Xanthine oxidase reaction with nitric oxide and peroxynitrite.

Abstract:

:Nitric oxide (.NO) and peroxynitrite (ONOO-) inhibit enzymes that depend on metal cofactors or oxidizable amino acids for activity. Since xanthine oxidase (XO) is a 2(2Fe2S) enzyme having essential sulfhydryl groups linked with Mo-pterin cofactor function, the influence of .NO and ONOO- on purified bovine XO was determined. Physiological (

journal_name

Arch Biochem Biophys

authors

Houston M,Chumley P,Radi R,Rubbo H,Freeman BA

doi

10.1006/abbi.1998.0675

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

1-8

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(98)90675-0

journal_volume

355

pub_type

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