Abstract:
:The management of locally advanced soft-tissue sarcomas (STS) of the extremities in patients who present with regional and/or distant metastases at the time of diagnosis remains an unsolved problem. The recently introduced hyperthermic isolated limb perfusion (HILP) with tumour necrosis factor (TNF)-alpha and melphalan has been shown to be an effective limb-saving treatment modality, but is it feasible to use this approach with palliative intent? Nine patients, five men and four women, mean age 41 (range 21-75) years with locally advanced extremity STS and regional (n = 3) or distant (n = 6) metastases at the time of diagnosis, underwent a palliative HILP with TNF-alpha and melphalan. Resection of the residual tumour mass was performed, if possible, 6-8 weeks after HILP. Treatment-related morbidity, local recurrences and the limb salvage rate were scored during follow-up. The median follow-up period was 9 (range 3-39) months (seven deaths, but six were due to metastatic disease). Treatment-related morbidity was seen after 3 of the 10 perfusions performed (30%) and consisted of superficial wound infections (n = 2), blow out of the external iliac artery followed by an iliac thrombosis (n = 1). Two patients showed local recurrences after HILP followed by resection of the residual tumour mass, and one patient showed local progression after two perfusions without resection. Limb salvage was achieved in 8 patients (89%). Therefore, HILP with TNF-alpha and melphalan for locally advanced extremity STS in patients with disseminated disease is feasible. The local management of locally advanced extremity STS should be the same whether the intent is curative or palliative, as the local control improves the quality of life.
journal_name
Arch Orthop Trauma Surgjournal_title
Archives of orthopaedic and trauma surgeryauthors
Olieman AF,van Ginkel RJ,Molenaar WM,Schraffordt Koops H,Hoekstra HJdoi
10.1007/s004020050314subject
Has Abstractpub_date
1998-01-01 00:00:00pages
70-4issue
1-2eissn
0936-8051issn
1434-3916journal_volume
118pub_type
杂志文章abstract::In 16 patients with an average age of 64.6 +/- 9.8 years and sudden onset of severe knee pain, the initial stage of Ahlbäck disease (spontaneous osteonecrosis of a femoral condyle) was verified by magnetic resonance imaging (MRI) and subsequent histology. The first radiological sign of osteonecrosis (flattening of the...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/BF00703433
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:We present a case series of three patients with manubriosternal dislocation and/or sternal fractures. METHOD:We describe our experiences of invasive surgical treatment with 3.5/4.0 mm fixed-angle plate (Locking compression plate, LCP) in this group of patients. Recommended nonoperative treatment options, ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-011-1297-2
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:While numerous classifications of hip arthritis have been proposed, none considered the magnitude and direction of femoral head translation relative to the native acetabulum. A more precise classification of architectural hip deformities is necessary to improve preoperative templating and anticipate surgic...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-019-03298-1
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:An isolated arthrodesis of the talocalcaneonavicular joint is a common indication in cases of pain and post-traumatic arthroses. MATERIALS AND METHODS:Because of the high infection rate after surgery with the lateral incision, the authors decided to evaluate an alternative, minimally invasive procedure. J...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-003-0627-4
更新日期:2004-11-01 00:00:00
abstract::We report here a case of colocutaneous fistula drained from the retroperitoneal space mimicking a cold abscess of the psoas muscle. A 60-year-old diabetic woman with a 6-year history of a chronic draining sinus over her right thigh had been treated intermittently with antibiotics. At presentation, she had no systemic ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s004020050050
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Hip and knee arthroplasties are frequently complicated by the need for allogeneic blood transfusions. The surveys were developed to assess the use of blood-saving measures in orthopedic surgery in the Netherlands in 2002 and 2007. STUDY DESIGN AND METHODS:In 2002 and 2007, a questionnaire on blood managemen...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-009-0910-0
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Open fractures are orthopaedic emergencies that carry a high risk for infection, non-union and soft tissue complications. Evidence-based treatment is impeded by the lack of high-quality evidence-based studies. The aim of this investigation was to elucidate the current practice of open fracture management in ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-016-2566-x
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:Purpose of this study was to establish and validate an MRI-associated classification to graduate postoperative results of MPFL reconstructions. METHODS:30 autologous MPFL reconstructions of 28 patients were evaluated by two independent raters using MRI. All grafts were assigned to a novel graduation system res...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-015-2349-9
更新日期:2016-02-01 00:00:00
abstract::The cortical bone area of the middle femur was investigated with computed tomography in 12 patients after hip rearthroplasty due to aseptic prosthetic loosening. The patients had undergone their original arthroplasty because of unilateral arthrosis 11 years before these measurements. Both legs were scanned, and the re...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00422836
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION/AIMS:Rotational alignment of the femoral prosthesis is important in total knee arthroplasty to improve performance and reduce complications. This study investigates the differences between two popular referencing methods and evaluates the variability of surgeons' techniques (inter-observer) and their repro...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-011-1273-x
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:The reliable diagnosis of partial-thickness tears of the rotator cuff is still elusive in clinical practise. Therefore, the purpose of the study was to determine the diagnostic accuracy of MR imaging and clinical tests for detecting partial-thickness tears of the rotator cuff as well as the combination of ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-017-2799-3
更新日期:2017-12-01 00:00:00
abstract::Thirteen patients with aneurysmal bone cyst of the spine (excluding sacral lesions) were retrospectively reviewed. Treatment for aneurysmal bone cysts remains controversial, but surgical resection, irradiation, and embolization are common treatment modalities for those involving the spine. Of 102 patients with aneurys...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s004020050381
更新日期:1999-01-01 00:00:00
abstract:AIM:Short-stemmed prostheses are increasingly regarded as implants of first choice in primary THA. As a result of the press-fit fixation in the femoral metaphysis, the occurrence of intraoperative fractures were reported. The aim of this study was to analyze the postoperative results of the Mayo short-stem prosthesis f...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-011-1342-1
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Proximal femoral nailing is a common operation in orthogeriatrics and a highly standardized procedure. For teaching purposes, this operation is often performed by residents and supervised by attending physicians. The objective of this study is to investigate if teaching this operation influences the surgical...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-012-1511-x
更新日期:2012-07-01 00:00:00
abstract:INTRODUCTION:Osteosynthesis of pertrochanteric fractures is one of the most frequently performed procedures in orthopaedic trauma care. Auto-dynamization during fracture healing can lead to lateralization of the screw or blade. This can cause debilitating complaints, which sometimes necessitate the removal of the screw...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-020-03435-1
更新日期:2020-11-01 00:00:00
abstract::A view through the posteromedial portal is necessary to observe the posterior portion of the knee joint such as the tibial attachment of the posterior cruciate ligament (PCL) or the posterior horn of the medial meniscus, which is barely, visible through anterior portals. Especially in arthroscopic PCL reconstruction, ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s004020050304
更新日期:1998-01-01 00:00:00
abstract::A case of painful junctura tendinum of the hand extensors is presented. This rare condition may have developed because of anatomical factors, including the type of connection and location of the junctura, and because of the unique position that the fingers assume during bowling. ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s004020050275
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Improved soft tissue tendon graft mechanical properties have led to their increased use for anterior cruciate ligament (ACL) reconstruction. Because they do not have an osseous component; however, there are greater concerns regarding tibial graft slippage during early postoperative rehabilitation and activ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-011-1374-6
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Review the literature concerning modalities to evaluate the integrity of the deltoid ligament in patients with supination external rotation ankle fractures. METHODS:The electronic databases Pubmed/Medline, CINAHL and Embase were searched from 1987 to November 2007 to identify all published origi...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章,评审
doi:10.1007/s00402-008-0768-6
更新日期:2009-02-01 00:00:00
abstract:INTRODUCTION:Scapho-trapezial-trapezoidal (STT) arthrodesis and proximal row carpectomy (PRC) are used for the treatment of Lichtman stage IIIB Kienböck's disease. This study prospectively compares 1-year results of STT arthrodesis and PRC in Lichtman stage IIIB Kienböck's disease. MATERIALS AND METHODS:Nineteen patie...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-012-1531-6
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:Controversy exists on optimal operative treatment of vertically unstable Neer IIB lateral clavicle fractures. Aim of this study was to analyse and compare clinical and radiological results and complications of locking plate osteosynthesis (LPO) versus hook plate osteosynthesis (HPO) with acromioclavicular ...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-017-2645-7
更新日期:2017-05-01 00:00:00
abstract::In this retrospective study we analyse the results of primary anterior cruciate ligament (ACL) sutures, primary ACL plasties and secondary ACL plasties 5 years after operation. All operations were performed with an additional PDS augmentation. Follow-ups of 100 of 130 patients could be done (80 male and 20 female). Th...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/BF00452087
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:Rotational acetabular osteotomy (RAO) has been used successfully in patients with developmental dysplasia of the hip (DDH). However, some patients are forced to undergo total hip arthroplasty (THA) because of the progression of osteoarthritis. We evaluated the effect of previous RAO on the outcome of THA p...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-015-2154-5
更新日期:2015-03-01 00:00:00
abstract::A 56-year-old female patient suffered a bimalleolar ankle fracture with an additional proximal fibular fracture. This is an unusual fracture type, seldom reported in literature. It was operatively treated by open reduction and internal fixation of the lateral malleolar fracture. The proximal fibular fracture was initi...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-005-0035-z
更新日期:2005-10-01 00:00:00
abstract:INTRODUCTION:Knee cartilage lesions are very frequent in arthroscopic surgery. This multi-center-study was aimed to evaluate the distribution and possible associated factors of these pathologies in more than 1000 patients. MATERIALS AND METHODS:The German cartilage registry (KnorpelRegister DGOU) started in 2013. In t...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s00402-016-2432-x
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:The direct anterior approach (DAA) is an increasingly popular technique for performing total hip arthroplasty (THA). This muscle-sparing approach may yield functional benefits. However, DAA has been associated with an increased risk incidence (RI) of intra- and postoperative complications. MATERIALS AND M...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00402-015-2258-y
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION:We conducted a prospective study to evaluate the long-term results after Corin C-Fit uncemented total hip arthroplasty in young patients with hydroxyapatite or porous coated components. MATERIALS AND METHODS:We prospectively followed 36 patients (38 hips) who had Corin C-Fit uncemented total hip arthropla...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-007-0557-7
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine functional and subjective results of patients who received arthroscopic debridement for their TFCC Palmer 1B lesions and to compare their results with those of arthroscopic suture repair. METHODS:Between March 2007 and August 2011, 36 patients were diagnosed with Palm...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-012-1643-z
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:We used a new internal fixative implant, the AO clavicle hook-plate, for treatment of unstable fractures of the distal clavicle. This study describes the operative procedure and the clinical results obtained, as well as discussion of the advantages and problems encountered. PATIENTS AND METHODS:Fifteen co...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/s00402-006-0284-5
更新日期:2007-04-01 00:00:00
abstract::Magnetic resonance imaging (MRI) and plain X-ray and CT studies were performed in patients with a history of lumbar back pain due to spinal disc disease. Spin-echo pulse sequences (SE), phase-contrast techniques (partial saturation sequences with delayed readout, PS), and fat-suppressing inversion recovery sequences (...
journal_title:Archives of orthopaedic and trauma surgery
pub_type: 杂志文章
doi:10.1007/BF00439383
更新日期:1990-01-01 00:00:00