Inhibition of nitrergic neurotransmission in the bovine retractor penis muscle by an oxidant stress: effects of superoxide dismutase mimetics.

abstract：:The effects of gamma-aminobutyric acid (GABA) applied by ionophoresis, pressure ejection and superfusion to myenteric neurones of the guinea-pig ileum were investigated by intracellular recording techniques. Ionophoretic or pressure application of GABA (10 pC-30 nC) caused membrane depolarizations of AH neurones but n...

journal_title：British journal of pharmacology

authors： Cherubini E,North RA

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Dimebolin (latrepirdine), a compound with multiple potential drug targets, is being evaluated in clinical trials for the treatment of Alzheimer's disease (AD) and preliminary results suggest it can slow the disease process. There is also evidence that dimebolin directly improves aspects of cognition. Here we...

journal_title：British journal of pharmacology

authors： Webster SJ,Wilson CA,Lee CH,Mohler EG,Terry AV Jr,Buccafusco JJ

更新日期：2011-10-01 00:00:00

abstract：:1 The prostaglandin synthesizing enzymes were found to be present in fat cell ghosts isolated from rabbit adipose tissue. 2 Prostaglandin E2 (PGE2) and PGF2, were synthesized by ghosts after stimulation with adrenocorticotrophic hormone (ACTH). 3 Indomethacin was found to inhibit this synthesis but not the synthesis o...

journal_title：British journal of pharmacology

authors： Lewis GP,Piper PJ,Vigo C

更新日期：1979-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Normal pregnancy is associated with decreased vascular resistance and increased release of vasodilators. Endothelin-1 (ET-1) causes vasoconstriction via endothelin receptor type A (ET(A)R), but could activate ET(B)R in the endothelium and release vasodilator substances. However, the roles of ET(B...

journal_title：British journal of pharmacology

authors： Mazzuca MQ,Dang Y,Khalil RA

更新日期：2013-07-01 00:00:00

abstract：:1. In mouse pancreatic beta-cells the regulation of the diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel (K-ATP-channel) was examined by use of the patch-clamp technique. 2. In intact beta-cells incubated at 37 degrees C in the presence of 3 mM D-glucose, diazoxide did not affect the single ...

journal_title：British journal of pharmacology

authors： Schwanstecher C,Dickel C,Ebers I,Lins S,Zünkler BJ,Panten U

更新日期：1992-09-01 00:00:00

abstract：:We examined whether a specific aminopeptidase P (APP) inhibitor, apstatin, increases vasodepressor responses to bradykinin in anaesthetized rats, and whether it would augment blood pressure responses further after treatment with the angiotensin-converting enzyme inhibitor (ACEi), lisinopril. Apstatin doubled the maxim...

journal_title：British journal of pharmacology

authors： Kitamura S,Carbini LA,Carretero OA,Simmons WH,Scicli AG

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N-type voltage-gated calcium (Cav 2.2) channels are critical determinants of increased neuronal excitability and neurotransmission accompanying persistent neuropathic pain. Although Cav 2.2 channel antagonists are recommended as first-line treatment for neuropathic pain, calcium-current blocking ...

journal_title：British journal of pharmacology

authors： Moutal A,Li W,Wang Y,Ju W,Luo S,Cai S,François-Moutal L,Perez-Miller S,Hu J,Dustrude ET,Vanderah TW,Gokhale V,Khanna M,Khanna R

更新日期：2018-06-01 00:00:00

abstract：:This paper is intended to assist pharmacologists to make the most of statistical analysis and avoid common errors. A scenario, in which an experimenter performed an experiment in two separate stages, combined the control groups for analysis and found some surprising results, is presented. The consequences of combined ...

journal_title：British journal of pharmacology

authors： Lew MJ

更新日期：2008-11-01 00:00:00

abstract：:1. Adenosine A(1), A(2A), and A(3) receptors (ARs) and extracellular signal-regulated kinase 1/2 (ERK1/2) play a major role in myocardium protection from ischaemic injury. In this study, we have characterized the adenosine receptor subtypes involved in ERK1/2 activation in newborn rat cardiomyocytes. 2. Adenosine (non...

journal_title：British journal of pharmacology

authors： Germack R,Dickenson JM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cannabidiol has been reported to act as an antagonist at cannabinoid CB1 receptors. We hypothesized that cannabidiol would inhibit cannabinoid agonist activity through negative allosteric modulation of CB1 receptors. EXPERIMENTAL APPROACH:Internalization of CB1 receptors, arrestin2 recruitment, ...

journal_title：British journal of pharmacology

authors： Laprairie RB,Bagher AM,Kelly ME,Denovan-Wright EM

更新日期：2015-10-01 00:00:00

abstract：:1. Interactions of bath-applied pentobarbitone and gamma-aminobutyric acid (GABA) on neurones in isolated superior cervical ganglia of the rat have been examined with intracellular microelectrodes. 2. Pentobarbitone itself (30 micrometer-1 mM) showed no clear or consistent GABA-like effects: changes in resting input c...

journal_title：British journal of pharmacology

authors： Brown DA,Constanti A

更新日期：1978-05-01 00:00:00

abstract：:Topical ophthalmic formulations of analogues of the endogenous arachidonic acid cyclooxygenase metabolite, PGF2α , are the standard of care treatment for the blinding disease glaucoma. These are the most potent and efficacious medical therapies for lowering intraocular pressure (IOP), the most important risk factor id...

journal_title：British journal of pharmacology

authors： Klimko PG,Sharif NA

更新日期：2019-04-01 00:00:00

abstract：:1. The purpose of this study was to develop and validate an integrated pharmacokinetic-pharmacodynamic model for the anti-lipolytic effects of the adenosine A1-receptor agonist N6-(p-sulphophenyl)adenosine (SPA). Tissue selectivity of SPA was investigated by quantification of haemodynamic and anti-lipolytic effects in...

journal_title：British journal of pharmacology

authors： van Schaick EA,de Greef HJ,Langemeijer MW,Sheehan MJ,IJzerman AP,Danhof M

更新日期：1997-10-01 00:00:00

abstract：:1. We studied the effect of bradykinin on plasma exudation in the airways of the anaesthetized guinea-pig in vivo. Tissue content of extravasated Evans blue dye was used as an index of protein exudation in the larynx, trachea, main bronchi and intrapulmonary airways (i.p.a.). 2. Bradykinin increased the content of Eva...

journal_title：British journal of pharmacology

authors： Rogers DF,Dijk S,Barnes PJ

更新日期：1990-11-01 00:00:00

abstract：:1 PD 117302, a new nonpeptide opioid compound shown in in vitro studies to be a selective kappa-opioid agonist, has been evaluated in vivo for antinociceptive activity and other effects characteristic of kappa-receptor activation. 2 Dose-related long lasting antinociception was produced by PD 117302 against a mechanic...

journal_title：British journal of pharmacology

authors： Leighton GE,Johnson MA,Meecham KG,Hill RG,Hughes J

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Red wine polyphenols (RWPs) inhibit the expression of vascular endothelial growth factor (VEGF), a major pro-angiogenic and pro-atherosclerotic factor, in vascular smooth muscle cells (VSMCs). The aim of this study was to identify which red wine polyphenols were inhibitory and to determine the me...

journal_title：British journal of pharmacology

authors： Oak MH,Bedoui JE,Madeira SV,Chalupsky K,Schini-Kerth VB

更新日期：2006-10-01 00:00:00

abstract：:1. The inhibitory transmission in isolated preparations of cavernosal smooth muscle from human penis has been studied. 2. Electrical field stimulation (EFS; 2-64 pulses/train, 0.8 ms pulse duration, 10 Hz) evoked relaxation of preparations treated with guanethidine (50 microM). The EFS-evoked relaxations were atropine...

journal_title：British journal of pharmacology

authors： Pickard RS,Powell PH,Zar MA

更新日期：1991-11-01 00:00:00

abstract：:1 Acetylcholine-induced contractions of the isolated chronically denervated soleus muscle of the mouse consist of two phases, but both phases are equivalent to the contracture phase seen in vivo.2 Low [Ca(2+)](0) (0.5-1.5 mM) augmented peak tension, as well as the rate of relaxation, of the first phase, but inhibited ...

journal_title：British journal of pharmacology

authors： Hall MT,Maleque MA,Wadsworth RM

更新日期：1977-12-01 00:00:00

abstract：:1. Dose-dependent vasodilator responses to dopamine, isoprenaline, noradrenaline, 3-isobutyl-1-methylxanthine (IBMX) and sodium nitroprusside were obtained in isolated perfused mesentery preparations, taken from reserpine-treated rats of different ages. The preparations were pretreated with phenoxybenzamine (1 microM)...

journal_title：British journal of pharmacology

authors： Wanstall JC,O'Donnell SR

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mitochondria possess their own source of cAMP, that is, soluble adenylyl cyclase (sAC). Activation or expression of mitochondrial sAC promotes mitochondrial function. Oestrogen receptor signalling plays an essential role in the regulation of mitochondrial function. Here we aimed to determine whet...

journal_title：British journal of pharmacology

authors： Pozdniakova S,Guitart-Mampel M,Garrabou G,Di Benedetto G,Ladilov Y,Regitz-Zagrosek V

更新日期：2018-10-01 00:00:00

abstract：:1. The effects of intrathecally (i.t.) injected substance P (SP), neurokinin A (NKA), [beta-Ala8]NKA (4-10) and [MePhe7]neurokinin B (NKB) at T13 thoracic spinal cord level were investigated on renal excretion of water, sodium and potassium in the conscious saline-loaded rat. Antagonists selective for NK1 (RP 67580), ...

journal_title：British journal of pharmacology

authors： Yuan YD,Couture R

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Strontium ranelate reduces fracture risk in postmenopausal women with osteoporosis. Evidence from non-clinical studies and analyses of bone markers in phase III trials indicate that this is due to an increase in osteoblast formation and a decrease of osteoclastic resorption. The aim of this work ...

journal_title：British journal of pharmacology

authors： Brennan TC,Rybchyn MS,Green W,Atwa S,Conigrave AD,Mason RS

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transient receptor potential melastatin 3 (TRPM3) proteins form non-selective but calcium-permeable membrane channels, rapidly activated by extracellular application of the steroid pregnenolone sulphate and the dihydropyridine nifedipine. Our aim was to characterize the steroid binding site by an...

journal_title：British journal of pharmacology

authors： Drews A,Mohr F,Rizun O,Wagner TF,Dembla S,Rudolph S,Lambert S,Konrad M,Philipp SE,Behrendt M,Marchais-Oberwinkler S,Covey DF,Oberwinkler J

更新日期：2014-02-01 00:00:00

abstract：:1 Administration of isoprenaline by aerosol inhalation to man results in over 80% being metabolized to the sulphate conjugate.2 The majority of an inhaled dose is probably swallowed since the metabolic pattern resembles that after an oral dose.3 Isoprenaline, administered in aqueous solution directly into the bronchia...

journal_title：British journal of pharmacology

authors： Blackwell EW,Briant RH,Conolly ME,Davies DS,Dollery CT

更新日期：1974-04-01 00:00:00

abstract：:1. The effects of ryanodine on changes in cytoplasmic Ca2+ level ([Ca2+]i) and muscle tension induced by maximum concentrations of phenylephrine (Phe; 1 microM), prostaglandin F2 alpha (PGF2 alpha, 10 microM), caffeine (Caf, 30 mM) and isoprenaline (Iso, 1 microM) were examined in rat aortic strips using fura-2. 2. In...

journal_title：British journal of pharmacology

authors： Hisayama T,Takayanagi I,Okamoto Y

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tolerance induced by morphine and other opiates remains a major unresolved problem in the clinical management of pain. There is now good evidence for the importance of MAPKs in morphine-induced antinociceptive tolerance. A member of the MAPK kinase kinase family, TGF-β activated kinase 1 (TAK1) i...

journal_title：British journal of pharmacology

authors： Xu H,Xu T,Ma X,Jiang W

更新日期：2015-06-01 00:00:00

abstract：:1. The present study was designed to characterize the positive inotropic response to DPI 201-106 in isolated papillary muscle strips obtained from heart failure patients undergoing surgery. 2. The positive inotropic responses to isoprenaline and milrinone and cardiac beta-adrenoceptor density were also determined. 3. ...

journal_title：British journal of pharmacology

authors： Böhm M,Diet F,Kemkes B,Wankerl M,Erdmann E

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The thiourea derivative KB-R7943, originally developed as inhibitor of the plasma membrane Na(+)/Ca(2+) exchanger, has been shown to protect against myocardial ischemia-reperfusion injury. We have studied here its effects on mitochondrial Ca(2+) fluxes. EXPERIMENTAL APPROACH:[Ca(2+)] in cytosol,...

journal_title：British journal of pharmacology

authors： Santo-Domingo J,Vay L,Hernández-Sanmiguel E,Lobatón CD,Moreno A,Montero M,Alvarez J

更新日期：2007-07-01 00:00:00

abstract：:Inhibition of myocardial Ca2+ channels was investigated for three dihydropyridines with different structural features: Ro 18-3981, darodipine (PY 108-068) and nifedipine. Ro 18-3981 contains a sulphamoyl acetyl side-chain. In voltage-clamps experiments with isolated cardiac myocytes of guinea-pig, Ro 18-3981 caused a ...

journal_title：British journal of pharmacology

authors： Holck M,Osterrieder W

更新日期：1987-05-01 00:00:00

abstract：:1 Rats treated for seven days with seryl-trihydroxybenzylhydrazine (benserazide), and inhibitor of peripheral aromatic L-amino acid decarboxylase (500 mg/kg, daily, i.p.) alone or in combination with L-DOPA methylester (500 mg/kg, daily, i.p.) for seven days showed a moderate but significant decrease of liver aldehyde...

journal_title：British journal of pharmacology

authors： Messiha FS

更新日期：1977-05-01 00:00:00