Determinants of psychotropic drug usage in a general intensive care unit.

Abstract:

:During a 3-month period, determinants of psychotropic drug utilization (sex, age, length of stay, reason for admission, disease severity) and data on psychotropic consumption (type of medication--antidepressants, benzodiazepines and antipsychotics--dosage and length of treatment) were retrospectively collected in a general intensive care unit of a Dutch university hospital. Daily exposure to psychotropics was standardized in number of Defined Daily Doses (DDD). Benzodiazepines were used by 35.8% of all patients (137) during their stay in the ICU whereas 17.5% of all patients used a neuroleptic agent. Antidepressants were hardly prescribed. High doses of benzodiazepines (9.9 DDDs) and low doses of antipsychotics (0.5 DDDs) were prescribed, which probably reflect the unusual nature of this critically ill group of patients compared with the reference group for DDD's. Clear patterns of determinants of psychotropic drug use in ICU patients were found and both benzodiazepines, antipsychotics and combined use of these agents could be associated with the determinants assessed. The time patterns we found in terms of length of stay give clues for further investigations in order to rationalize psychotropic drug use in the management of severely ill and complex patients.

journal_name

Gen Hosp Psychiatry

authors

Stolker JJ,Heerdink ER,Pullen SE,Santman FW,Hekster YA,Leufkens HG,Zitman FG

doi

10.1016/s0163-8343(98)00048-6

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

371-6

issue

6

eissn

0163-8343

issn

1873-7714

pii

S0163834398000486

journal_volume

20

pub_type

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