Blood leucocyte enzymes. III. Diurnal rhythm of activity in isolated lymphocytes of normal subjects and chronic lymphatic leukaemia patients.

abstract：:The surface markers of immunoglobulin secreting cells (ISC) in bone marrow and peripheral blood were analysed. Circulating ISC bear surface Ig and Ia-like antigens. However, these markers were not detectable on ISC in bone marrow. Fc and complement receptors were not present on circulating ISC. The areas of plaques co...

journal_title：British journal of haematology

authors： Gyotoku Y,Mori M,Nonaka Y,Nagata Y,Saito Y

更新日期：1985-04-01 00:00:00

abstract：:The retinoids: all-transretinoic acid (tretinoin), 13-cis retinoic acid (isotretinoin) and the aromatic retinoids etretinate and acitretin have a preventive and therapeutic effect on chemically-induced tumours. Clinically, retinoids have shown variable effectiveness in therapy and/or prevention of oncological diseases...

journal_title：British journal of haematology

authors： Bollag W

更新日期：1991-10-01 00:00:00

abstract：:The use of allogeneic haematopoietic stem cell transplantation (Allo-HSCT) is a standard treatment option for many patients with haematological malignancies. Historically, patients requiring intensive care unit (ICU) admission for transplant-related toxicities have fared extremely poorly, with high ICU mortality rates...

journal_title：British journal of haematology

authors： Townsend WM,Holroyd A,Pearce R,Mackinnon S,Naik P,Goldstone AH,Linch DC,Peggs KS,Thomson KJ,Singer M,Howell DC,Morris EC

更新日期：2013-05-01 00:00:00

abstract：:During the past years, several authors have used labelled leucocytes to detect inflammatory foci. However, before routine use in man. It is necessary to control the viability of labelled cells. Five leucocyte labelling techniques (111In-oxine, 111In-oxine without extraction, 99mTc oxine, pyrophosphate 99mTc, 51Cr) wer...

journal_title：British journal of haematology

authors： Colas-Linhart N,Barbu M,Gougerot MA,Bok B

更新日期：1983-01-01 00:00:00

abstract：:Megakaryocytic (Mk) cell maturation involves polyploidisation, and the number of platelets produced increases with Mk DNA content. Ploidy levels in cultured human MK cells are much lower than those observed in vivo. This study demonstrated that adding the water-soluble vitamin nicotinamide (NIC) to mobilised periphera...

journal_title：British journal of haematology

authors： Giammona LM,Fuhrken PG,Papoutsakis ET,Miller WM

更新日期：2006-11-01 00:00:00

abstract：:We evaluated the performance of eight d-assays for the exclusion of deep vein thrombosis (DVT); Biopool AutoDimer, Biopool MiniQuant, bioMèrieux MDA D-Dimer, VIDAS, Dade Behring D-Dimer Plus, Trinity Biotech AMAX, NycoCard D-dimer and IL Test D-Dimer. The assays were evaluated both as stand-alone tests, and in combina...

journal_title：British journal of haematology

authors： Gardiner C,Pennaneac'h C,Walford C,Machin SJ,Mackie IJ

更新日期：2005-03-01 00:00:00

abstract：:The EGFP-tk retroviral vector, encoding enhanced green fluorescent protein (EGFP) and the herpes simplex virus thymidine kinase (HSV-tk) packaged in a Phoenix amphotropic cell line, was used to transduce healthy donor T lymphocytes. Infection yielded a mean of 41.8 +/- 9.3% SD (range 31.1-48.4%) EGFP-positive cells an...

journal_title：British journal of haematology

authors： Di Florio S,Sebastiani C,Fagioli M,Di Ianni M,Alfonsi D,Venditti G,Pelicci PG,Tabilio A

更新日期：2000-09-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) was previously demonstrated to be a mediator of oxidative stress-induced apoptosis in irradiated neoplastic B-cells and B-cell precursors. Defective BTK expression in leukaemic B-cell precursors from infants with t(4;11) acute lymphoblastic leukaemia has been associated with radiation re...

journal_title：British journal of haematology

authors： Uckun F,Ozer Z,Vassilev A

更新日期：2007-02-01 00:00:00

abstract：:Twenty-one cases of acute promyelocytic leukaemia (FAB M3) demonstrating t(15,17) chromosomal translocation were studied in detail by immunocytochemical techniques using a panel of monoclonal antibodies. A characteristic myeloid phenotype of the leukaemic cells, co-expression of CD9 and CD68 antigens and absence of HL...

journal_title：British journal of haematology

authors： Erber WN,Asbahr H,Rule SA,Scott CS

更新日期：1994-09-01 00:00:00

abstract：:Highly efficient systems remove toxic and pro-inflammatory haemoglobin (Hb) from the circulation and local sites of tissue damage. Macrophages are major Hb-clearing cells; CD163 was recently recognized as the specific haemoglobin-haptoglobin scavenger receptor (HSR). We show that dexamethasone strongly induced the spe...

journal_title：British journal of haematology

authors： Schaer DJ,Boretti FS,Schoedon G,Schaffner A

更新日期：2002-10-01 00:00:00

abstract：:A study has been made of a number of haematological and haemorheological factors following venesection therapy. Haematocrit was very effectively reduced by the venesection regimen and led to a fall in whole blood viscosity in spite of the microcytosis that was eventually induced in all the subjects. No clinically sign...

journal_title：British journal of haematology

authors： Challoner T,Briggs C,Rampling MW,Thomas DJ

更新日期：1986-04-01 00:00:00

abstract：:This trial explored the efficacy of re-induction chemotherapy including bortezomib in paediatric relapsed/refractory acute lymphoblastic leukaemia. Patients were randomized 1:1 to bortezomib (1.3 mg/m2 /dose) administered early or late to a dexamethasone and vincristine backbone. Both groups did not differ regarding p...

journal_title：British journal of haematology

authors： Kaspers GJL,Niewerth D,Wilhelm BAJ,Scholte-van Houtem P,Lopez-Yurda M,Berkhof J,Cloos J,de Haas V,Mathôt RA,Attarbaschi A,Baruchel A,de Bont ES,Fagioli F,Rössig C,Klingebiel T,De Moerloose B,Nelken B,Palumbo G,Reinhar

更新日期：2018-05-01 00:00:00

abstract：:The use of 111Indium oxine as a platelet label for the performance of platelet life-span studies has been examined. Platelet life-span in normal subjects varied between 8 X 10 and 10 X 36 d. Patients with primary thrombocythaemia had clearly reduced platelet life-span whether or not they presented with vascular occlus...

journal_title：British journal of haematology

authors： Bautista AP,Buckler PW,Towler HM,Dawson AA,Bennett B

更新日期：1984-12-01 00:00:00

abstract：:Sickle cell disease (SCD) affects approximately 100,000 people in the US, 12,500 in the UK, and millions worldwide. SCD is typified by painful vaso-occlusive episodes, haemolytic anaemia and organ damage. A secondary complication is infection, which can be bacterial, fungal or viral. Universal newborn screening, routi...

journal_title：British journal of haematology

authors： Sobota A,Sabharwal V,Fonebi G,Steinberg M

更新日期：2015-09-01 00:00:00

abstract：:We studied the trends of the Epstein-Barr virus (EBV) positivity rate in Hodgkin's disease (HD) between 1955 and 1999. The overall positivity rate gradually decreased over time [12 out of 23 (52%) in 1955-69; 18 out of 39 (46%) in 1970-84; 13 out of 44 (35%) in 1985-99; P = 0.135]. Interestingly, a marked decrease in ...

journal_title：British journal of haematology

authors： Takeuchi K,Morishita Y,Fukayama M,Mori S

更新日期：2001-05-01 00:00:00

abstract：:The clinico-pathological features of 12 cases of malignant histiocytosis (histiocytic medullary reticulosis), aged 12-60 years, were studied. Special emphasis was put on the analysis of the haematological, cytological and histopathological findings of the disease. Bone marrow aspirates and biopsies from involved tissu...

journal_title：British journal of haematology

authors： Lampert IA,Catovsky D,Bergier N

更新日期：1978-09-01 00:00:00

abstract：:Recent findings have indicated the importance of factor V (FV) in causing resistance to activated protein C (APC) in a high proportion of patients with venous thrombosis. This prompted us to investigate whether resistance could be due to defective inactivation of FVa by APC. Consequently, we amplified a 3.2 kb fragmen...

journal_title：British journal of haematology

authors： Beauchamp NJ,Daly ME,Hampton KK,Cooper PC,Preston FE,Peake IR

更新日期：1994-09-01 00:00:00

abstract：:ImMucin, a 21-mer cancer vaccine encoding the signal peptide domain of the MUC1 tumour-associated antigen, possesses a high density of T- and B-cell epitopes but preserves MUC1 specificity. This phase I/II study assessed the safety, immunity and clinical response to 6 or 12 bi-weekly intradermal ImMucin vaccines, co-a...

journal_title：British journal of haematology

authors： Carmon L,Avivi I,Kovjazin R,Zuckerman T,Dray L,Gatt ME,Or R,Shapira MY

更新日期：2015-04-01 00:00:00

abstract：:Proteasome inhibition induces the accumulation of aggregated misfolded/ubiquitinated proteins in the aggresome; conversely, histone deacetylase 6 (HDAC6) inhibition blocks aggresome formation. Although this rationale has been the basis of proteasome inhibitor (PI) and HDAC6 inhibitor combination studies, the role of d...

journal_title：British journal of haematology

authors： Mishima Y,Santo L,Eda H,Cirstea D,Nemani N,Yee AJ,O'Donnell E,Selig MK,Quayle SN,Arastu-Kapur S,Kirk C,Boise LH,Jones SS,Raje N

更新日期：2015-05-01 00:00:00

abstract：:Cyclosporin A (CSA) exhibits greater multidrug resistance (MDR) modulating activity in vitro than other MDR modulators such as verapamil and quinidine. However, the immunosuppressive and nephrotoxic effects of CSA may limit its clinical use. PSC 833, a new cyclosporin D derivative, exerts a higher MDR reversal activit...

journal_title：British journal of haematology

authors： Jiang XR,Kelsey SM,Wu YL,Newland AC

更新日期：1995-06-01 00:00:00

abstract：:We report stability of a clonal immunoglobulin heavy chain (IgH) gene rearrangement in a case of childhood acute lymphoblastic leukaemia (ALL) relapsing 17 years after completion of first-line therapy. Clonal stability was shown by polymerase chain reaction amplification of the hypervariable CDRIII region of IgH gene....

journal_title：British journal of haematology

authors： Frost L,Goodeve A,Wilson G,Peake I,Barker H,Vora A

更新日期：1997-09-01 00:00:00

abstract：:We report outcomes after myeloablative haematopoietic cell transplantation (HCT) from human leucocyte antigen (HLA)-matched sibling donors in 67 patients with sickle cell disease transplanted between 1989 and 2002. The most common indications for transplantation were stroke and recurrent vaso-occlusive crisis in 38% a...

journal_title：British journal of haematology

authors： Panepinto JA,Walters MC,Carreras J,Marsh J,Bredeson CN,Gale RP,Hale GA,Horan J,Hows JM,Klein JP,Pasquini R,Roberts I,Sullivan K,Eapen M,Ferster A,Non-Malignant Marrow Disorders Working Committee, Center for International Bl

更新日期：2007-06-01 00:00:00

abstract：:The prevalence, clinical associations and pathogenic role of newly identified autoantibodies to the erythropoietin receptor (EPOR) in patients with anaemia were investigated. Sera from 203 patients with immune-related or chronic kidney diseases were screened for anti-EPOR antibodies by enzyme-linked immunosorbent assa...

journal_title：British journal of haematology

authors： Hara A,Furuichi K,Higuchi M,Iwata Y,Sakai N,Kaneko S,Wada T

更新日期：2013-01-01 00:00:00

abstract：:We prospectively studied presentation biological differences and the response to therapy in patients with thrombotic thrombocytopenic purpura (TTP) associated with, or unrelated to human immunodeficiency virus (HIV) infection. TTP patients underwent standard evaluations and were treated with prednisone 1 mg/kg in addi...

journal_title：British journal of haematology

authors： Novitzky N,Thomson J,Abrahams L,du Toit C,McDonald A

更新日期：2005-02-01 00:00:00

abstract：:Calcium uptake into isolated membrane vesicles from two patients with a grey platelet syndrome has been investigated. An increase in calcium transport appears in both patients when compared to controls. Determination of the kinetic parameters of the calcium transport system gave similar apparent affinity for calcium a...

journal_title：British journal of haematology

authors： Enouf J,Lebret M,Bredoux R,Levy-Toledano S,Caen JP

更新日期：1987-04-01 00:00:00

abstract：:The incidence of acute biphenotypic leukaemia has ranged from less than 1% to almost 50% in various reports in the literature. This wide variability may be attributed to a number of reasons including lack of consistent diagnostic criteria, use of various panels of antibodies, and the failure to recognize the lack of l...

journal_title：British journal of haematology

authors： Hanson CA,Abaza M,Sheldon S,Ross CW,Schnitzer B,Stoolman LM

更新日期：1993-05-01 00:00:00

abstract：:125I IgG anti-D binding to reticulocytes obtained by density fractionation is reduced relative to that bound to all other red cell (RBC) fractions. Maximum D antigen reactivity occurs following reticulocyte maturation with no detectable change in D reactivity of mature RBC throughout their life span. Reticulocytes hav...

journal_title：British journal of haematology

authors： Gray LS,Kleeman JE,Masouredis SP

更新日期：1983-10-01 00:00:00

abstract：:Myelodysplastic syndrome (MDS) is a common neoplasm of haematopoietic pluripotent stem cells. Although one third of MDS patients evolve to acute myeloid leukaemia (AML), little is understood about the mechanisms responsible for this progression. We have previously detected the frequent loss of heterozygosity (LOH) on ...

journal_title：British journal of haematology

authors： Mori N,Morosetti R,Mizoguchi H,Koeffler HP

更新日期：2003-07-01 00:00:00

abstract：:Membrane protein synthesis in human immature erythroid cells was studied by incubating the cells with 35S-methionine in vitro. The radioactive precursor amino acid was incorporated into membrane protein in a linear fashion for approximately 60 min, after which there was only a slight increase in incorporation. Intrace...

journal_title：British journal of haematology

authors： Krasnow SH,Pielichowski HJ,Caro J,Burka ER,Ballas SK

更新日期：1981-02-01 00:00:00

abstract：:Recent studies have suggested the HoxA10, HoxA11 and HoxD11 homeobox genes as candidate loci for the thrombocytopenia with absent radius (TAR) syndrome. For example, targeted disruptions of these Hox genes result in abnormal development of the mouse radius, while overexpression of HoxA10 stimulates mouse megakaryocyte...

journal_title：British journal of haematology

authors： Fleischman RA,Letestu R,Mi X,Stevens D,Winters J,Debili N,Vainchenker W

更新日期：2002-02-01 00:00:00