Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats.

abstract：:1. Exposure of isolated skeletal muscle to troglitazone has resulted in inconsistent findings ranging from inhibition to stimulation of fuel oxidation and the glycogenic pathway. To better understand such variation in outcome, the present study used isolated rat soleus muscle strips to examine the interdependent influ...

journal_title：British journal of pharmacology

authors： Gras F,Brunmair B,Roden M,Waldhäusl W,Fürnsinn C

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Partial agonists selective for α4β2 nicotinic ACh receptors have been developed for smoking cessation as they induce weak activation of native α4β2* receptors and inhibit effect of nicotine. However, it is unclear whether at brain functions there is an existence of receptor reserve that allows we...

journal_title：British journal of pharmacology

authors： Chen Y,Broad LM,Phillips KG,Zwart R

更新日期：2012-02-01 00:00:00

abstract：:1 A newly synthesized substance P (SP) analogue, (D-Pro2, D-Trp7,9)-SP, specifically antagonizes the contractile effects of SP on the guinea-pig isolated taenia coli. In addition, previous studies had indicated that the SP analogue per se is capable of contracting this preparation. The results of the present study on ...

journal_title：British journal of pharmacology

authors： Håkanson R,Hörig J,Leander S

更新日期：1982-12-01 00:00:00

abstract：:1. The variation with clock-hour in the behaviour of naive rats in a Y-maze has been recorded.2. The number of entries recorded was highest during the light period while the number of faecal boluses was highest during the dark period. Rearing showed a biphasic periodicity.3. The responses to LSD, mescaline and ampheta...

journal_title：British journal of pharmacology

authors： Davies JA,Redfern PH

更新日期：1973-09-01 00:00:00

abstract：:Bradykinin, angiotensin II, arginine vasopressin (AVP) or des-amino-D-arginine vasopressin (DDAVP) were administered by intravenous infusion to 10 healthy men. The concentration of 6-oxo-prostaglandin F1 alpha (6-oxo-PGF1 alpha), the stable hydrolysis product of prostacyclin (PGI2), was measured in plasma using gas ch...

journal_title：British journal of pharmacology

authors： Barrow SE,Dollery CT,Heavey DJ,Hickling NE,Ritter JM,Vial J

更新日期：1986-01-01 00:00:00

abstract：:1. Prolongation of action potentials by cooling or pharmacological treatment can restore conduction in demyelinated axons. We have assessed the ability of pyrethroids (in vitro) to modify action potential kinetics and to reverse conduction block in lesioned peripheral nerve. 2. Fast Na+ currents were isolated in mamma...

journal_title：British journal of pharmacology

authors： Lees G

更新日期：1998-02-01 00:00:00

abstract：:1. This study compares a cyclo-oxygenase inhibitor (aspirin), a 5-HT2 antagonist (ZM170809) and a combined thromboxane synthase inhibitor/receptor antagonist (ZD1542) as adjuncts to tissue plasminogen activator (rt-PA). 2. Application of an anodal current (332 +/- 4.1 microA) to the stenosed left circumflex coronary a...

journal_title：British journal of pharmacology

authors： McAuliffe SJ,Moors JA,Jones HB

更新日期：1994-05-01 00:00:00

abstract：:Although cyclosporin (CsA) is considered to be the best immunosuppressive molecule in transplantation, it has been suspected to alter mitochondrial respiration of various tissues. We evaluated the acute effect of CsA and its vehicle on maximal oxidative capacity (V(max)) of cardiac, soleus and gastrocnemius muscles of...

journal_title：British journal of pharmacology

authors： Sanchez H,Zoll J,Bigard X,Veksler V,Mettauer B,Lampert E,Lonsdorfer J,Ventura-Clapier R

更新日期：2001-07-01 00:00:00

abstract：:1. 5-HT and the prostanoid TP receptor agonists, U46619 and I-BOP, constricted the human umbilical artery with pEC50 values of 7.3+/-0. 2, 6.7+/-0.1, and 7.3+/-0.2, respectively. The selective TP receptor antagonist, GR32191 (0.1 microM), shifted the concentration-effect curves to U46619 and I-BOP to the right, but ha...

journal_title：British journal of pharmacology

authors： Boersma JI,Janzen KM,Oliveira L,Crankshaw DJ

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to identify the actions of H(2)S on ion transport across rat distal colon. EXPERIMENTAL APPROACH:Changes in short-circuit current (Isc) induced by the H(2)S-donor, NaHS, were measured in Ussing chambers. Cytosolic Ca(2+) concentration was evaluated using fura-2. KEY RE...

journal_title：British journal of pharmacology

authors： Hennig B,Diener M

更新日期：2009-11-01 00:00:00

abstract：:1 Neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP) differentially activate three Y receptors (Y(1), Y(2) and Y(4)) in mouse and human isolated colon. 2 The aim of this study was to characterise Y(2) receptor-mediated responses in colon mucosa and longitudinal smooth muscle preparations from wild ...

journal_title：British journal of pharmacology

authors： Hyland NP,Sjöberg F,Tough IR,Herzog H,Cox HM

更新日期：2003-06-01 00:00:00

abstract：:An increasing number of examples in the literature suggest that the in vivo duration of drug action not only depends on macroscopic pharmacokinetic properties like plasma half-life and the time needed to equilibrate between the plasma and the effect compartments, but is also influenced by long-lasting target binding a...

journal_title：British journal of pharmacology

authors： Vauquelin G,Charlton SJ

更新日期：2010-10-01 00:00:00

abstract：:1. We examined the effect of the sulphonylurea glimepiride on three types of recombinant ATP-sensitive potassium (K(ATP)) channels. 2. K(ATP) channels share a common pore-forming subunit, Kir6.2, which associates with different sulphonylurea receptor isoforms (SUR1 in beta-cells, SUR2A in heart and SUR2B in smooth mus...

journal_title：British journal of pharmacology

authors： Song DK,Ashcroft FM

更新日期：2001-05-01 00:00:00

abstract：:1. In the present study we have characterized the parathyroid hormone (PTH)-induced calcium signalling in 293 cells stably transfected with the human PTH receptor cDNA. In these cells, human PTH-1(1-38) strongly stimulates adenosine 3':5'-cyclic monophosphate (cyclic AMP) formation (EC50 = 0.39 nM) but fails to activa...

journal_title：British journal of pharmacology

authors： Seuwen K,Boddeke HG

更新日期：1995-04-01 00:00:00

abstract：:The discovery of an additional duplicated alpha-2 adrenoceptor subtype in the zebrafish raises a pesky nomenclature issue, as well as questions about the functions of the alpha-2 adrenoceptors in the zebrafish and how many alpha-2 receptors does an organism really need. ...

journal_title：British journal of pharmacology

authors： Bylund DB

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Kyotorphin (KTP; L-Tyr-L-Arg), an endogenous neuropeptide, is potently analgesic when delivered directly to the central nervous system. Its weak analgesic effects after systemic administration have been explained by inability to cross the blood-brain barrier (BBB) and detract from the possible cl...

journal_title：British journal of pharmacology

authors： Ribeiro MM,Pinto A,Pinto M,Heras M,Martins I,Correia A,Bardaji E,Tavares I,Castanho M

更新日期：2011-07-01 00:00:00

abstract：:1. The aim of this study was to investigate whether the hypotensive effect of rat alpha-calcitonin gene-related peptide (alpha CGRP) in conscious rats is mediated by endothelium-derived nitric oxide (NO) or the opening of adenosine 5'-triphosphate (ATP)-sensitive potassium (KATP) channels. 2. Dose-mean arterial pressu...

journal_title：British journal of pharmacology

authors： Abdelrahman A,Wang YX,Chang SD,Pang CC

更新日期：1992-05-01 00:00:00

abstract：:1. By use of patch-clamp techniques, the effects of SD-3212, a novel antiarrhythmic drug, on the calcium current (Ica), the sodium current (INa) and the muscarinic acetylcholine-receptor-operated potassium current (IK.ACh) were examined and compared with those of bepridil in guinea-pig single atrial cells. 2. SD-3212 ...

journal_title：British journal of pharmacology

authors： Hara Y,Nakaya H

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Δ9 -tetrahydrocannabinol (THC) acts via cannabinoid CB1 receptors to increase feeding. Here, we assessed the orexigenic effect of AM11101, a novel CB1 receptor agonist designed to have a more favourable pharmacodynamic profile than THC. EXPERIMENTAL APPROACH:The acute, orexigenic effects of AM11...

journal_title：British journal of pharmacology

authors： Ogden SB,Malamas MS,Makriyannis A,Eckel LA

更新日期：2019-10-01 00:00:00

abstract：:The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5-hydroxytryptamine (5-HT) and histamine. There was no differential effect of any of the secretagogues tested on the secretion of 5-HT and h...

journal_title：British journal of pharmacology

authors： Carraway RE,Cochrane DE,Granier C,Kitabgi P,Leeman E,Singer EA

更新日期：1984-02-01 00:00:00

abstract：:1. In order to define the electrophysiological mechanism(s) responsible for bradykinin (BK)-induced positive inotropic and chronotropic responses in isolated guinea-pig atria, effects of BK on the membrane currents were examined in isolated atrial cells using patch clamp techniques. 2. BK (0.1-1000 nM) increased the L...

journal_title：British journal of pharmacology

authors： Sakamoto N,Uemura H,Hara Y,Saito T,Masuda Y,Nakaya H

更新日期：1998-09-01 00:00:00

abstract：:Ischaemia is amongst the leading causes of death. Despite this importance, there are only a few therapeutic approaches to protect from ischaemia-reperfusion injury (IRI). In experimental studies, the amino acid glycine effectively protected from IRI. In the prevention of IRI by glycine in cells and isolated perfused o...

journal_title：British journal of pharmacology

authors： Petrat F,Boengler K,Schulz R,de Groot H

更新日期：2012-04-01 00:00:00

abstract：:Cyclic adenosine 3',5'-monophosphage (cyclic AMP) levels in guinea-pig tracheal rings increased on incubation with the vasoactive intestinal peptide (VIP). The effect was potentiated by the addition of theophylline. The results suggest that the tracheo-bronchial relaxant action of VIP may be mediated by stimulation of...

journal_title：British journal of pharmacology

authors： Frandsen EK,Krishna GA,Said SI

更新日期：1978-03-01 00:00:00

abstract：:1. In order to explore whether 5-HT4 receptor subtypes exist, we have characterized further the 5-HT4 receptor that mediates tachycardia in the piglet isolated right atrium. All experiments were carried out in the presence of propranolol (400 nM) and cocaine (6 microM). We used tryptamine derivatives, substituted benz...

journal_title：British journal of pharmacology

authors： Medhurst AD,Kaumann AJ

更新日期：1993-11-01 00:00:00

abstract：:1. We studied the effects of intracerebroventricular (i.c.v.) administration of prostanoid EP receptor ligands on vagally stimulated gastric acid secretion in rats anaesthetized with urethane. 2. Administration of misoprostol (EP3/EP2 receptor agonist) and sulprostone (EP3/EP1 receptor agonist) reduced vagally mediate...

journal_title：British journal of pharmacology

authors： Yokotani K,Okuma Y,Osumi Y

更新日期：1996-02-01 00:00:00

abstract：:The presence of functional cannabinoid CB2 receptors in the CNS has provoked considerable controversy over the past few years. Formerly considered as an exclusively peripheral receptor, it is now accepted that it is also present in limited amounts and distinct locations in the brain of several animal species, includin...

journal_title：British journal of pharmacology

authors： Benito C,Tolón RM,Pazos MR,Núñez E,Castillo AI,Romero J

更新日期：2008-01-01 00:00:00

abstract：:Knock-out (KO) mouse technology has given pharmacologists a powerful tool to study function in the absence of selective antagonists or inhibitors. Such KO technology can confirm predicted function, serendipitously reveal unrecognized function, or help define the mode of action of a drug. In this issue, Liles et al. de...

journal_title：British journal of pharmacology

authors： Docherty JR

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study was to investigate the structure-activity relationship of S-alkyl-L-isothiocitrulline-containing dipeptides towards three partially purified recombinant human nitric oxide synthase (NOS) isozymes, as well as the effects of these compounds on cytokine-induced NO production by human DLD-1 cells. In...

journal_title：British journal of pharmacology

authors： Park JM,Higuchi T,Kikuchi K,Urano Y,Hori H,Nishino T,Aoki J,Inoue K,Nagano T

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Avoiding danger and finding food are closely related behaviours that are essential for surviving in a natural environment. Growing evidence supports an important role of gut-brain peptides in modulating energy homeostasis and emotional-affective behaviour. For instance, postprandial release of pa...

journal_title：British journal of pharmacology

authors： Verma D,Hörmer B,Bellmann-Sickert K,Thieme V,Beck-Sickinger AG,Herzog H,Sperk G,Tasan RO

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Metformin, a small molecule, antihyperglycaemic agent, is a well-known activator of AMP-activated protein kinase (AMPK) and protects against cardiac fibrosis. However, the underlying mechanisms remain elusive. TGFβ1 is a key cytokine mediating cardiac fibrosis. Here, we investigated the effects o...

journal_title：British journal of pharmacology

authors： Chen R,Feng Y,Wu J,Song Y,Li H,Shen Q,Li D,Zhang J,Lu Z,Xiao H,Zhang Y

更新日期：2018-04-01 00:00:00