Increasing isoflurane from 0.9 to 1.1 minimum alveolar concentration minimally affects dorsal horn cell responses to noxious stimulation.

abstract：BACKGROUND:Glucocorticoids have been reported to aggravate ischemic brain damage. Because changes in the activities of various neuronal systems are closely related to the outcome of ischemic damage, the authors evaluated the effects of dexamethasone on the monoaminergic systems and ischemic neuronal damage. METHODS:Th...

journal_title：Anesthesiology

authors： Tsubota S,Adachi N,Chen J,Yorozuya T,Nagaro T,Arai T

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Systemic inflammation is a key feature in acid aspiration-induced acute respiratory distress syndrome (ARDS), but the factors that trigger inflammation are unclear. The authors hypothesize that extracellular histones, a newly identified inflammatory mediator, play important roles in the pathogenesis of ARDS....

journal_title：Anesthesiology

authors： Zhang Y,Wen Z,Guan L,Jiang P,Gu T,Zhao J,Lv X,Wen T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Recent trials indicate that rapacuronium's pharmacokinetic characteristics are influenced by both renal failure and cirrhosis but the time course of a single bolus dose of 1.5 mg/kg is affected minimally. The authors reassessed these pharmacokinetic findings and examined the time course of the same bolus dos...

journal_title：Anesthesiology

authors： Fisher DM,Dempsey GA,Atherton DP,Brown R,Abengochea A,Hunter JM

更新日期：2000-12-01 00:00:00

abstract：:Inorganic fluoride (F-) production and renal function were assessed in six groups of Fischer 344 rats administered either methoxyflurane (MOF) or deuterated methoxyflurane (d4-MOF). One untreated and one phenobarbital (PB)-treated group were exposed for two hours to either air, 0.5 per cent (V/v) MOF, or 0.5 per cent ...

journal_title：Anesthesiology

authors： Baden JM,Rice SA,Mazze RI

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Work suggests the amnesia from dexmedetomidine (an α2-adrenergic agonist) is caused by a failure of information to be encoded into long-term memory and that dexmedetomidine might differentially affect memory for emotionally arousing material. We investigated these issues in humans using event-related neuroim...

journal_title：Anesthesiology

authors： Hayama HR,Drumheller KM,Mastromonaco M,Reist C,Cahill LF,Alkire MT

更新日期：2012-11-01 00:00:00

abstract：:The slow positive (P2) wave of the evoked electrospinogram was recorded from the dorsal epidural space in man. The waveform characteristics of the P2 wave were similar to those of the dorsal cord positive wave (P wave), which is believed to be caused by the primary afferent depolarization (PAD) and to be related to pr...

journal_title：Anesthesiology

authors： Shimoji K,Ito Y,Oama K,Sawa T,Ikezono E

更新日期：1975-10-01 00:00:00

abstract：:This study examined the efficacy of patient-controlled epidural analgesia (PCEA) during labor and compared the suitability of three different PCEA solutions. After establishing effective epidural analgesia with 12 ml of 0.25% bupivacaine, 72 parturients in active labor were randomly assigned to one of four groups: phy...

journal_title：Anesthesiology

authors： Lysak SZ,Eisenach JC,Dobson CE 2nd

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Chronic pain is associated with depression. In rodents, pain is often assessed by sensory hypersensitivity, which does not sufficiently measure affective responses. Low-dose ketamine has been used to treat both pain and depression, but it is not clear whether ketamine can relieve depression associated with c...

journal_title：Anesthesiology

authors： Wang J,Goffer Y,Xu D,Tukey DS,Shamir DB,Eberle SE,Zou AH,Blanck TJ,Ziff EB

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The linearity of cisatracurium elimination and its concentration-effect relation were determined as part of a traditional rich data study with three dose levels in patients receiving balanced anesthesia. METHODS:Forty-eight adults with American Society of Anesthesiologists status I-II were randomized to rec...

journal_title：Anesthesiology

authors： Bergeron L,Bevan DR,Berrill A,Kahwaji R,Varin F

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:The authors conducted a randomized controlled trial to determine whether parental presence during induction of anesthesia (PPIA) is associated with parental physiologic and behavioral manifestations of stress. METHODS:Children and their parents (N = 80) were randomly assigned to one of three groups: (1) PPI...

journal_title：Anesthesiology

authors： Kain ZN,Caldwell-Andrews AA,Mayes LC,Wang SM,Krivutza DM,LoDolce ME

更新日期：2003-01-01 00:00:00

abstract：:To determine whether anesthesiologists can manually detect significant changes in pulmonary compliance in neonates using an "educated hand," the authors tested whether clinicians could detect clamping of an endotracheal tube connecting a neonatal lung model to one of three anesthesia breathing circuits. The test lungs...

journal_title：Anesthesiology

authors： Spears RS Jr,Yeh A,Fisher DM,Zwass MS

更新日期：1991-10-01 00:00:00

abstract：:Malpractice claims filed against anesthesiologists for care involving obstetric (OB) anesthesia (n = 190) were taken from the American Society of Anesthesiologists' Closed Claims Database and compared to claims not involving OB cases (n = 1351). The most common complications in the OB claims were (percentage of all OB...

journal_title：Anesthesiology

authors： Chadwick HS,Posner K,Caplan RA,Ward RJ,Cheney FW

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Arginine vasopressin (AVP) is an important "stress" hormone that is known to play a key role in cardiovascular homeostasis of the systemic circulation. In contrast, the effects of AVP on the pulmonary circulation have not been extensively investigated, and the extent to which general anesthesia alters the pu...

journal_title：Anesthesiology

authors： Trempy GA,Nyhan DP,Murray PA

更新日期：1994-09-01 00:00:00

abstract：:Decreased urinary output (Vu ml/min) after institution of PEEP is attributed to a variety of mechanisms including decreased cardiac output and renal blood flow (RBF), activation of neurohormonal reflexes, increased catecholamines, plasma renin activity (PRA), and antidiuretic hormone (ADH) release. To evaluate these f...

journal_title：Anesthesiology

authors： Payen DM,Farge D,Beloucif S,Leviel F,De La Coussaye JE,Carli P,Wirquin V

更新日期：1987-01-01 00:00:00

abstract：WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Traumatic brain injury induces cellular proliferation in the hippocampus, which generates new neurons and glial cells during recovery. This process is regulated by N-methyl-D-aspartate-type glutamate receptors, which are inhibite...

journal_title：Anesthesiology

authors： Peters AJ,Villasana LE,Schnell E

更新日期：2018-08-01 00:00:00

abstract：:The authors investigated the effects of a volatile anesthetic (isoflurane) on the functional properties of a well characterized membrane ion channel (the acetylcholine receptor channel), using the patch clamp electrophysiological method together with local microperfusion of isoflurane. They found that isoflurane cause...

journal_title：Anesthesiology

authors： Brett RS,Dilger JP,Yland KF

更新日期：1988-08-01 00:00:00

abstract：:The aim of the study was to establish whether there exists a relationship between blood methadone concentration and analgesic response and the intrasubject and intersubject variability in this relationship. Sixteen general surgical (upper abdominal) and orthopedic (spinal fusion) patients were administered methadone (...

journal_title：Anesthesiology

authors： Gourlay GK,Willis RJ,Wilson PR

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Pain behavior in response to skin incision is developmentally regulated, but little is known about the underlying neuronal mechanisms. The authors hypothesize that the spatial activation and intensity of dorsal horn neuron responses to skin incision differ in immature and adult spinal cord. METHODS:Single w...

journal_title：Anesthesiology

authors： Ririe DG,Bremner LR,Fitzgerald M

更新日期：2008-10-01 00:00:00

abstract：:Eighty-six patients undergoing coronary artery bypass graft (n = 63) or intracardiac (n = 23) surgery were randomly assigned with respect to the target value for PaCO2 during cardiopulmonary bypass. In 44 patients the target PaCO2 was 40 mmHg, measured at the standard electrode temperature of 37 degrees C, while in 42...

journal_title：Anesthesiology

authors： Bashein G,Townes BD,Nessly ML,Bledsoe SW,Hornbein TF,Davis KB,Goldstein DE,Coppel DB

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The spinal delivery of the cholinesterase inhibitor neostigmine yields analgesia in rats and augments the analgesic effects of alpha 2 agonists in sheep. To assess its activity in humans, preclinical toxicology studies to define its safety were required in two species. METHODS:Rats with chronic intrathecal ...

journal_title：Anesthesiology

authors： Yaksh TL,Grafe MR,Malkmus S,Rathbun ML,Eisenach JC

更新日期：1995-02-01 00:00:00

abstract：:The occurrence of fasciculations following administration of agents is a well-known pharmacologic phenomenon. Using the cat soleus nerve-muscle preparation, intravenous neostigmine doses between 20-200 micrograms/kg evoked fasciculations in a dose-related manner. The data demonstrate that the fasciculations were the r...

journal_title：Anesthesiology

authors： Baker T,Stanec A

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Pulse oximeters have been reported to fail to record data in 1.12-2.50% of cases in which anesthesia records were handwritten. There is reason to believe that these may be underestimates. Computerized anesthesia records may provide insight into the true incidence of pulse oximetry data failures and factors t...

journal_title：Anesthesiology

authors： Reich DL,Timcenko A,Bodian CA,Kraidin J,Hofman J,DePerio M,Konstadt SN,Kurki T,Eisenkraft JB

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Opioids are used by patients who have conditions ranging from the acute pain of surgery and chronic cancer pain to substance abuse. Despite their widespread use and considerable experimental data about them, little is known about how opioids may alter in vivo immunity in humans. This study was designed to ev...

journal_title：Anesthesiology

authors： Yeager MP,Colacchio TA,Yu CT,Hildebrandt L,Howell AL,Weiss J,Guyre PM

更新日期：1995-09-01 00:00:00

abstract：:There is controversy about whether N2O increases cerebral blood flow and cortical oxygen consumption (CMRO2) in rats. Cortical and subcortical blood flow and CMRO2 were measured in awake, unrestrained rats while awake and during 70% N2O administration using radioactive microspheres. In the awake state, cortical and su...

journal_title：Anesthesiology

authors： Baughman VL,Hoffman WE,Miletich DJ,Albrecht RF

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Pain following thoracotomy can persist for years with an undetermined impact on quality of life. Factors hypothesized to modulate this painful experience include analgesic regimen, gender, and type of incision. METHODS:A total of 157 generally healthy patients of both genders scheduled for segmentectomy, lo...

journal_title：Anesthesiology

authors： Ochroch EA,Gottschalk A,Augostides J,Carson KA,Kent L,Malayaman N,Kaiser LR,Aukburg SJ

更新日期：2002-11-01 00:00:00

abstract：:Hepatic venous oxygen saturation (ShvO2) was continuously monitored in 33 consecutive patients undergoing hepatic lobectomy. Fiberoptic pulmonary artery catheters were inserted into the hepatic vein (HV) and in the pulmonary artery through the right internal jugular vein before anesthetic induction. The success rate a...

journal_title：Anesthesiology

authors： Kainuma M,Fujiwara Y,Kimura N,Shitaokoshi A,Nakashima K,Shimada Y

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Protamine causes multiple adverse reactions. Heparinase I, a specific enzyme that inactivates heparin, is a possible alternative to protamine. In this study, the authors examined the efficacy of heparinase I to reverse heparin-induced anticoagulation in vitro and compared heparinase I to protamine as an anta...

journal_title：Anesthesiology

authors： Michelsen LG,Kikura M,Levy JH,Lee MK,Lee KC,Zimmermann JJ,Szlam F

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:This study was design to assess clinical agitation, electroencephalogram (EEG) and autonomic cardiovascular activity changes in children during induction of anesthesia with sevoflurane compared with halothane using noninvasive recording of EEG, heart rate, and finger blood pressure. METHODS:Children aged 2-...

journal_title：Anesthesiology

authors： Constant I,Dubois MC,Piat V,Moutard ML,McCue M,Murat I

更新日期：1999-12-01 00:00:00

abstract：:We performed a prospective randomized controlled trial to assess the efficacy of a chlorhexidine dressing in reducing the microbial flora at the insertion site of epidural catheters. These catheters were used for acute pain management and were dressed either by a standardized method or with a CHX/urethane sponge compo...

journal_title：Anesthesiology

authors： Shapiro JM,Bond EL,Garman JK

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Rapid development of acute opioid tolerance is well established in animals and is more likely to occur with large doses of short-acting drugs. The authors therefore tested the hypothesis that intraoperative remifentanil administration results in acute opioid tolerance that is manifested by increased postoper...

journal_title：Anesthesiology

authors： Guignard B,Bossard AE,Coste C,Sessler DI,Lebrault C,Alfonsi P,Fletcher D,Chauvin M

更新日期：2000-08-01 00:00:00