Abstract:
:A patient with the M2 subtype of AML who had a 45,X,-X,t(8;21) karyotype at diagnosis was found to have the Ph chromosome in one out of 37 evaluated cells 18 months after the initial diagnosis. Interphase FISH studies utilizing a BCR-ABL dual-color probe did not detect a fusion product 4 months prior to the appearance of one Ph-positive cell. Nineteen months post diagnosis and 5 months after clinical relapse all evaluated cells had the Ph chromosome in a clone characterized by t(8;21). These observations suggest that late appearing Ph is a secondary event which may be either therapy-related or consistent with one of the later events in a multistep pathogenesis of AML.
journal_name
Leukemiajournal_title
Leukemiaauthors
Najfeld V,Geller M,Troy K,Scalise Adoi
10.1038/sj.leu.2400974subject
Has Abstractpub_date
1998-04-01 00:00:00pages
517-9issue
4eissn
0887-6924issn
1476-5551journal_volume
12pub_type
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