Abstract：
:We compared the efficacy of timolol maleate ophthalmic gel-forming solution 0.5% QD with that of levobunolol hydrochloride 0.5% BID, as measured by change in intraocular pressure (IOP), effect on heart rate, and ocular tolerability. The study had a positive-controlled, double-masked, randomized, multicenter, 12-week, two-period (6 weeks each), crossover design. One hundred fifty-two patients with open-angle glaucoma or ocular hypertension were randomized to receive either timolol maleate gel-forming solution QD or levobunolol BID for 6 weeks, followed by a crossover to the alternate treatment. IOP and heart rate were measured at morning trough and peak during weeks 3, 6, 9, and 12. Timolol maleate gel-forming solution QD was comparable to levobunolol BID in reducing IOP at peak and trough. Although the effects on peak heart rate were similar between the two medications, the effect on trough heart rate of timolol maleate gel-forming solution QD was significantly less than that of levobunolol BID (P = 0.001). The incidence of ocular burning and stinging was comparable between the two treatments. Patients experienced significantly more blurred vision when using timolol maleate gel-forming solution than when using levobunolol (P = 0.013). Overall, more patients experienced at least one adverse event when using timolol maleate gel-forming solution. Timolol maleate gel-forming solution QD is as efficacious in reducing IOP as levobunolol BID.
journal_name
Clin Therjournal_title
Clinical therapeuticsauthors
Walters TR,Maloney S,Slater D,Liss C,Wilson H,Hartenbaum Ddoi
10.1016/s0149-2918(98)80112-4subject
Has Abstractpub_date
1998-11-01 00:00:00pages
1170-8issue
6eissn
0149-2918issn
1879-114Xpii
S0149-2918(98)80112-4journal_volume
20pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：:A total of 804 pediatric patients (572 neonates and 232 infants and children) with suspected or documented serious infections were enrolled in a multicenter open study of netilmicin, a new semisynthetic aminoglycoside. All patients were evaluable for safety; 161 (20%) had bacteriologically documented infections and we...
journal_title：Clinical therapeutics
pub_type： 临床试验,杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND:Despite increasing investigation in the area of cardiovascular instability in preterm infants, huge gaps in knowledge remain. None of the current treatments for hypotension, including the use of inotropic agents, have been well studied in the preterm population, and data regarding safety and efficacy are lac...
journal_title：Clinical therapeutics
pub_type： 杂志文章,评审
doi：10.1016/j.clinthera.2006.09.006
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abstract：BACKGROUND:Due to Mexico's complicated socioeconomic environment, causing a high occurrence of >1 person sharing a single room, respiratory conditions are spread easily. Respiratory conditions are the main reason for consultation with a physician. The most frequent symptoms are throat soreness and cough; therefore, a n...
journal_title：Clinical therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:In Korea, the treatment of hypertension and dyslipidemia constitutes an important strategy for the prevention of cardiovascular disease (CVD). OBJECTIVE:This study sought to investigate the cost-effectiveness (from the Korean health care system perspective) of prescribing a proprietary formulation single-ta...
journal_title：Clinical therapeutics
pub_type： 杂志文章
doi：10.1016/j.clinthera.2009.10.015
更新日期：2009-10-01 00:00:00
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journal_title：Clinical therapeutics
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journal_title：Clinical therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1981-01-01 00:00:00
abstract：PURPOSE:Respiratory syncytial virus (RSV) and influenza are important viral pathogens worldwide. Children, in particular, bear considerable burdens of morbidity and mortality associated with these viruses. There are limited therapeutic options for children infected with RSV or influenza. This review focuses on therapeu...
journal_title：Clinical therapeutics
pub_type： 杂志文章
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journal_title：Clinical therapeutics
pub_type： 杂志文章
doi：10.1016/j.clinthera.2017.06.008
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journal_title：Clinical therapeutics
pub_type： 杂志文章,meta分析,评审
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更新日期：2013-10-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章,随机对照试验
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更新日期：2008-12-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章
doi：10.1016/j.clinthera.2014.04.007
更新日期：2014-05-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章,评审
doi：10.1016/s0149-2918(98)80018-0
更新日期：1998-01-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章,评审
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journal_title：Clinical therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-12-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章,meta分析
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更新日期：2019-12-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章,评审
doi：10.1016/j.clinthera.2010.01.021
更新日期：2010-01-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-01-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章,评审
doi：
更新日期：1985-01-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 共识发展会议,杂志文章,评审
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journal_title：Clinical therapeutics
pub_type： 杂志文章,评审
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更新日期：2011-05-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 临床试验,杂志文章
doi：
更新日期：1985-01-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Clinical therapeutics
pub_type： 杂志文章,评审
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更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:In the United States, patients with high-risk stage II or III melanoma are often treated with adjuvant interferon (IFN) therapy for 1 year after surgery. Adverse events associated with IFN alfa-2b use are primarily constitutional symptoms. However, hypertriglyceridemia requiring treatment has been reported. ...
journal_title：Clinical therapeutics
pub_type： 杂志文章
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更新日期：2005-12-01 00:00:00
