In vivo iron mobilisation evaluation of hydroxypyridinones in 59Fe-ferritin-loaded rat model.

Abstract:

:Although there are a number of well-characterised animal models available for testing and comparing the efficacy of iron chelators, most are expensive to operate and are not capable of providing rapid and reproducible results. The method described herein is based on the labelling of rat liver with 59Fe using rat 59Fe-ferritin. This method produces highly reproducible data of the type necessary for dose-response investigations, comparison of the efficacies of different administration routes, and structure activity studies.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Liu ZD,Lu SL,Hider RC

doi

10.1016/s0006-2952(98)00319-0

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

559-66

issue

5

eissn

0006-2952

issn

1873-2968

pii

S0006-2952(98)00319-0

journal_volume

57

pub_type

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