Abstract:
:Although there are a number of well-characterised animal models available for testing and comparing the efficacy of iron chelators, most are expensive to operate and are not capable of providing rapid and reproducible results. The method described herein is based on the labelling of rat liver with 59Fe using rat 59Fe-ferritin. This method produces highly reproducible data of the type necessary for dose-response investigations, comparison of the efficacies of different administration routes, and structure activity studies.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Liu ZD,Lu SL,Hider RCdoi
10.1016/s0006-2952(98)00319-0subject
Has Abstractpub_date
1999-03-01 00:00:00pages
559-66issue
5eissn
0006-2952issn
1873-2968pii
S0006-2952(98)00319-0journal_volume
57pub_type
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