Abstract:
:Highly chemo- and regioselective de-esterification has been observed in the deacetylation of peracetylated enolic forms of polyphenolic benzyl phenyl ketones by lipase from porcine pancreas (PPL) suspended in tetrahydrofuran (THF). The enzyme selectively deacetylates the enolic acetoxy over the phenolic acetoxy group(s) and continuation of the reaction resulted, in addition the regioselective deacetylation of acetoxy function para to the nuclear carbonyl group.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Parmar VS,Pati HN,Azim A,Kumar R,Himanshu,Bisht KS,Prasad AK,Errington Wdoi
10.1016/s0968-0896(97)10010-4subject
Has Abstractpub_date
1998-01-01 00:00:00pages
109-18issue
1eissn
0968-0896issn
1464-3391pii
S0968089697100104journal_volume
6pub_type
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