Lipase-catalysed selective deacetylation of phenolic/enolic acetoxy groups in peracetylated benzyl phenyl ketones.

Abstract:

:Highly chemo- and regioselective de-esterification has been observed in the deacetylation of peracetylated enolic forms of polyphenolic benzyl phenyl ketones by lipase from porcine pancreas (PPL) suspended in tetrahydrofuran (THF). The enzyme selectively deacetylates the enolic acetoxy over the phenolic acetoxy group(s) and continuation of the reaction resulted, in addition the regioselective deacetylation of acetoxy function para to the nuclear carbonyl group.

journal_name

Bioorg Med Chem

authors

Parmar VS,Pati HN,Azim A,Kumar R,Himanshu,Bisht KS,Prasad AK,Errington W

doi

10.1016/s0968-0896(97)10010-4

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

109-18

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968089697100104

journal_volume

6

pub_type

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