Further characterization of thyroid hormone response elements in the human type 1 iodothyronine deiodinase gene.

abstract：:The ileal proglucagon-derived peptides (PGDPs) play important roles in the regulation of gastric function and insulin secretion. We have previously demonstrated the existence of a proximal-distal enteroendocrine loop mediated by glucose-dependent insulinotropic peptide (GIP), through which intestinal PGDP secretion is...

journal_title：Endocrinology

authors： Roberge JN,Gronau KA,Brubaker PL

更新日期：1996-06-01 00:00:00

abstract：:It has been shown that acute administration of interleukin-1 (IL-1) to rats elicits a transitory increase in plasma ACTH and corticosterone (B) levels. To investigate the effects of chronic administration of IL-1 on plasma ACTH and B levels, in the present study rats were equipped with Alzet osmotic minipumps loaded w...

journal_title：Endocrinology

authors： Sweep CG,van der Meer MJ,Hermus AR,Smals AG,van der Meer JW,Pesman GJ,Willemsen SJ,Benraad TJ,Kloppenborg PW

更新日期：1992-03-01 00:00:00

abstract：:With the use of rabbit anti-LH-RH serum, a system of delicate nerve fibers and terminals which contain immunoreactive LH-RH can be demonstrated in the median eminence of the rat, corresponding exactly to the tubero-infundibular tract as described earlier with the aid of classical neurophistological methods. The delica...

journal_title：Endocrinology

authors： Sétáló G,Vigh S,Schally AV,Arimura A,Flerkó B

更新日期：1975-01-01 00:00:00

abstract：:Intermittent PTH administration increases bone turnover, resulting in net anabolic effects on bone. These effects are primarily mediated by intracellular cAMP signaling. However, the molecular mechanisms that regulate PTH activity in bone remain incompletely understood. beta-Arrestin2, a G protein-coupled receptor reg...

journal_title：Endocrinology

authors： Ferrari SL,Pierroz DD,Glatt V,Goddard DS,Bianchi EN,Lin FT,Manen D,Bouxsein ML

更新日期：2005-04-01 00:00:00

abstract：:In muscle, physiologic hyperinsulinemia, presumably acting on endothelial cells (ECs), dilates arterioles and regulates both total blood flow and capillary recruitment, which in turn influences glucose disposal. In cultured ECs, however, supraphysiological (e.g. >or=10 nM) insulin concentrations are typically used to ...

journal_title：Endocrinology

authors： Li G,Barrett EJ,Wang H,Chai W,Liu Z

更新日期：2005-11-01 00:00:00

abstract：:The uptake of [125I]triiodothyroacetic acid ([125I]Triac) in anterior pituitary cells was investigated and compared with that of [125I]T3. Furthermore, the effects of Triac, T3, and T4 on TSH release were compared. Cells isolated from adult male Wistar rats were cultured for 3 days in medium with 10% fetal calf serum....

journal_title：Endocrinology

authors： Everts ME,Visser TJ,Moerings EP,Docter R,van Toor H,Tempelaars AM,de Jong M,Krenning EP,Hennemann G

更新日期：1994-12-01 00:00:00

abstract：:This is an obituary for Gregory Goodwin Pincus whose death in August, 1967, terminated a distinguished career in the biological sciences. His major work was in reproductive biology. This work, in collaboration with Dr. John Rock, led to the development and field testing in Puerto Rico of the 1st OC (oral contracepti...

journal_title：Endocrinology

authors： White A

更新日期：1968-04-01 00:00:00

abstract：:The adipokine, leptin (LEP), is a hormonal gateway, signaling energy stores to appetite-regulatory neurons, permitting reproduction when stores are sufficient. Dual-labeling for LEP receptors (LEPRs) and gonadotropins or GH revealed a 2-fold increase in LEPR during proestrus, some of which was seen in LH gonadotropes....

journal_title：Endocrinology

authors： Akhter N,CarlLee T,Syed MM,Odle AK,Cozart MA,Haney AC,Allensworth-James ML,Beneš H,Childs GV

更新日期：2014-10-01 00:00:00

abstract：:We have investigated the interaction of estrogen with GnRH on the regulation of LH subunit mRNA in female hypogonadal (hpg) mice receiving constant frequency and amplitude pulsatile GnRH treatment for up to 18 days. The level of cytosolic common alpha mRNA in female hpg mouse pituitaries was 45 +/- 6% of normal female...

journal_title：Endocrinology

authors： Saade G,London DR,Clayton RN

更新日期：1989-04-01 00:00:00

abstract：:Anterior pituitary cells from adult male rats were cultured on a natural extracellular matrix (ECM). From the 5th day, spindle-shaped cells, fusing to form elongated fibers, were observed among the epithelial cells. These fibers later increased in size and number and were identified as striated muscle fibers, based on...

journal_title：Endocrinology

authors： Spira O,Atzmon R,Rahamim E,Bar-Shavit R,Gross J,Gordon A,Vlodavsky I

更新日期：1988-06-01 00:00:00

abstract：:The neuronal growth-associated protein (GAP)-43 has been localized in both long fibers and punctate clusters by immunocytochemistry within the rat anterior pituitary (AP). After adrenalectomy (ADX), GAP-43 immunoreactivity (GAP-43-ir) is greatly increased and is associated with corticotrophs at the light microscopic l...

journal_title：Endocrinology

authors： Paden CM,Watt JA,Selong TH,Paterson CL,Cranston HJ

更新日期：2006-02-01 00:00:00

abstract：:The effects of morphine on the release of dopamine from tuberoinfundibular neurons and the release of PRL from the anterior pituitary gland were studied in diestrous female rats. Morphine ions ejected iontophoretically in minute quantities into the arcuate nuclei (using one electrode per nucleus) were found to reduce ...

journal_title：Endocrinology

authors： Haskins JT,Gudelsky GA,Moss RL,Porter JC

更新日期：1981-03-01 00:00:00

abstract：:Interleukin (IL)-10 is a highly important anti-inflammatory cytokine in the immune system. CD1dhi and CD5+ B cells are both traditionally defined IL-10-secreting B cells. In recent years, a B cell group with combined markers of CD1dhi and CD5+ has been widely studied as it has been reported to suppress autoimmunity in...

journal_title：Endocrinology

authors： Qin J,Zhao N,Wang S,Liu S,Liu Y,Cui X,Wang S,Xiang Y,Fan C,Li Y,Shan Z,Teng W

更新日期：2020-04-01 00:00:00

abstract：:Maternal obesity at conception increases the risk of offspring obesity, thus propagating an intergenerational vicious cycle. Male offspring born to obese dams are hyperresponsive to high fat-diets, gaining greater body weight, fat mass, and additional metabolic sequelae compared to lean controls. In this report, we id...

journal_title：Endocrinology

authors： Shankar K,Zhong Y,Kang P,Lau F,Blackburn ML,Chen JR,Borengasser SJ,Ronis MJ,Badger TM

更新日期：2011-11-01 00:00:00

abstract：:The effects of continuous high GH levels on GH signal transduction through the GH receptor (GHR)/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) pathway as well as the desensitization of this pathway by suppressors of cytokine signaling (SOCS) were studied in transgenic mice overexpres...

journal_title：Endocrinology

authors： González L,Miquet JG,Sotelo AI,Bartke A,Turyn D

更新日期：2002-02-01 00:00:00

abstract：:The objective of this study was to assess estrogen-dependent cellular mechanisms that could contribute to the acid pH of the vaginal lumen. Cultures of normal human cervical-vaginal epithelial (hECE) cells and endocervical cells were grown on filters, and acidification of the extracellular solutions on the luminal (L-...

journal_title：Endocrinology

authors： Gorodeski GI,Hopfer U,Liu CC,Margles E

更新日期：2005-02-01 00:00:00

abstract：:The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. However, the mechanism by which these compounds manifest their activity in bone is unknown. We have used a series of in vitro screens to select for compounds that are mechanistically ...

journal_title：Endocrinology

authors： Willson TM,Norris JD,Wagner BL,Asplin I,Baer P,Brown HR,Jones SA,Henke B,Sauls H,Wolfe S,Morris DC,McDonnell DP

更新日期：1997-09-01 00:00:00

abstract：:Molecular size heterogeneities of PRL and GH in mice of the high mammary tumor C3H/St strain and low mammary tumor C57BL/St strain were compared under different physiological states. At least three size variants, the big (void volume), the intermediate (dimeric), and the little (monomeric) forms, of both hormones were...

journal_title：Endocrinology

authors： Sinha YN

更新日期：1980-12-01 00:00:00

abstract：:A major issue of in the treatment of diabetes is the risk of hypoglycemia. Hypoglycemia is detected both centrally and peripherally in the porto-hepatic area. The portal locus for hypoglycemic detection was originally described using the "local irrigation of the liver" approach in a canine model. Further work using po...

journal_title：Endocrinology

authors： Ionut V,Castro AV,Woolcott OO,Stefanovski D,Iyer MS,Broussard JL,Mkrtchyan H,Burch M,Elazary R,Kirkman E,Bergman RN

更新日期：2014-04-01 00:00:00

abstract：:Berberine, a hypoglycemic agent, has recently been shown to activate AMP-activated protein kinase (AMPK) contributing to its beneficial metabolic effects in peripheral tissues. However, whether berberine exerts a regulatory effect on beta-cells via AMPK or other signaling pathways and counteracts glucolipotoxicity rem...

journal_title：Endocrinology

authors： Zhou L,Wang X,Shao L,Yang Y,Shang W,Yuan G,Jiang B,Li F,Tang J,Jing H,Chen M

更新日期：2008-09-01 00:00:00

abstract：:Although atrial and brain natriuretic peptides are well known to be involved in the regulation of cardiovascular and endocrine functions as circulating hormones, the roles of the C-type natriuretic peptide (CNP) remain unknown. We examined the effects of CNP on the secretion of aldosterone and cyclic nucleotides from ...

journal_title：Endocrinology

authors： Kawai M,Naruse M,Yoshimoto T,Naruse K,Shionoya K,Tanaka M,Morishita Y,Matsuda Y,Demura R,Demura H

更新日期：1996-01-01 00:00:00

abstract：:The dynamics of dopamine (DA) action on PRL release was studied in superfused rat anterior pituitary cell aggregates, cultured for for 5 days either in conventional or in serum-free defined medium. In aggregates cultured in conventional medium 0.1-1 nM DA applied for 20 min provoked a rapid and concentration-dependent...

journal_title：Endocrinology

authors： Denef C,Baes M,Schramme C

更新日期：1984-04-01 00:00:00

abstract：:Periodontitis, an inflammatory disease of periodontal tissues, is characterized by excessive alveolar bone resorption. An increase in the receptor activator of nuclear factor-κB ligand (RANKL) to osteoprotegerin (OPG) ratio is thought to reflect the severity of periodontitis. Here, we examined alveolar bone loss in OP...

journal_title：Endocrinology

authors： Koide M,Kobayashi Y,Ninomiya T,Nakamura M,Yasuda H,Arai Y,Okahashi N,Yoshinari N,Takahashi N,Udagawa N

更新日期：2013-02-01 00:00:00

abstract：:Endocrine regulation of uterine biology is critical for embryo receptivity and human reproduction. Uterine endometrium depends on extrinsic sex steroid input and hence likely has mechanisms that enable adaptation to hormonal variation. Emerging evidence suggests that sex steroid bioavailability in the endometrium is d...

journal_title：Endocrinology

authors： Zheng Y,Tabbaa ZM,Khan Z,Schoolmeester JK,El-Nashar S,Famuyide A,Keeney GL,Daftary GS

更新日期：2014-11-01 00:00:00

abstract：:Developmental exposures to phthalates are suspected to contribute to risk of metabolic syndrome. However, findings from human studies are inconsistent, and long-term metabolic impacts of early-life phthalate and phthalate mixture exposures are not fully understood. Furthermore, most animal studies investigating metabo...

journal_title：Endocrinology

authors： Neier K,Cheatham D,Bedrosian LD,Gregg BE,Song PXK,Dolinoy DC

更新日期：2019-07-01 00:00:00

abstract：:PTH secretion is tightly regulated by extracellular calcium ([Ca2+]e) and in turn regulates calcium homeostasis through its action on target tissues. We investigated the mechanism and physiological significance of intracellular calcium ([Ca2+]i) levels in relation to the secretion of PTH in single bovine parathyroid c...

journal_title：Endocrinology

authors： Miki H,Maercklein PB,Fitzpatrick LA

更新日期：1995-07-01 00:00:00

abstract：:The hormonal requirements for lactogenesis were investigated using explant cultures of mammary tissue obtained from cows at 30-40 days prepartum. Hormones used were insulin, hydrocortisone, and prolactin, and parameters examined were radioactive acetate incorporation into fatty acids, secretory response ratings, and h...

journal_title：Endocrinology

authors： Collier RJ,Bauman DE,Hays RL

更新日期：1977-04-01 00:00:00

abstract：:The effect of collagenase dissociation of virgin mouse mammary glands on the level of mammary epithelial cytosolic estrogen receptors (ER) and progesterone receptors (PR) was assessed. After cell dissociation, ER was present in mammary epithelial cells at concentrations similar to those found in the whole gland. Howev...

journal_title：Endocrinology

authors： Edery M,Imagawa W,Larson L,Nandi S

更新日期：1985-01-01 00:00:00

abstract：:A time-course study was performed to correlate serum gonadotropin changes after ovariectomy (OVX) or OVX plus acute estradiol (E2) treatment with LHRH content and norepinephrine (NE) and dopamine (DA) content and turnover in the suprachiasmatic-medial preoptic region (SCH-PO), the medial basal hypothalamus (MBH), and ...

journal_title：Endocrinology

authors： Advis JP,McCann SM,Negro-Vilar A

更新日期：1980-10-01 00:00:00

abstract：:GH3 cells are a PRL-secreting adenoma cell line derived from pituitary lactotropes. These cells have been stably transfected with rat GnRH receptor complementary DNA to produce four cell lines: GGH(3)1', GGH(3)2', GGH(3)6', and GGH(3)12'. In response to either GnRH or Buserelin (a metabolically stable GnRH agonist), t...

journal_title：Endocrinology

authors： Stanislaus D,Arora V,Awara WM,Conn PM

更新日期：1996-03-01 00:00:00