Methyldopa-induced liver injury. Rapid progression to fatal postnecrotic cirrhosis.

Abstract:

:A 55-year-old woman developed symptoms suggestive of hepatitis 12 weeks after first receiving methyldopa for hypertension. Liver biopsy showed chronic aggressive hepatitis with subacute hepatic necrosis. Methyldopa was discontinued, but after exhibiting transient clinical improvement, the patient's condition progressively deteriorated until she died of hepatic failure, in spite of therapy with massive doses of corticosteroids and other nonspecific measures. During the terminal stage, a considerable decrease in the size of the liver was observed. At autopsy, the liver was found to be small, shrunken, and scarred; histological sections demonstrated postnecrotic cirrhosis. Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.

journal_name

Arch Pathol Lab Med

authors

Thomas E,Bhuta S,Rosenthal WS

subject

Has Abstract

pub_date

1976-03-01 00:00:00

pages

132-5

issue

3

eissn

0003-9985

issn

1543-2165

journal_volume

100

pub_type

杂志文章
  • Isolated intracranial involvement in Rosai-Dorfman disease: a report of two cases and review of the literature.

    abstract::Rosai-Dorfman disease is an idiopathic histiocytic disorder of lymph nodes and extranodal sites. Central nervous system manifestations of this disease are rare, and to our knowledge only 16 cases of intracranial involvement have been reported previously. Intracranial Rosai-Dorfman disease clinically and radiologically...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Deodhare SS,Ang LC,Bilbao JM

    更新日期:1998-02-01 00:00:00

  • Keratin and involucrin in preneoplastic and neoplastic lesions. Distribution in the nasal mucosa of nickel workers.

    abstract::Nasal mucosal biopsy specimens encompassing normal and pathological epithelia were obtained from nickel workers, a population with an increased incidence of carcinomas of the respiratory tract. The immunohistochemical detection of keratins was carried out using monoclonal antibodies AE1 and AE3. The antibody AE1 stain...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Klein-Szanto AJ,Boysen M,Reith A

    更新日期:1987-11-01 00:00:00

  • Sclerosing mucoepidermoid carcinoma of the parotid gland.

    abstract::Although mucoepidermoid carcinoma is the most common primary malignancy of the salivary glands, the sclerosing morphologic variant of this tumor is extremely rare, with only 6 reported cases. As its name suggests, sclerosing mucoepidermoid carcinoma is characterized by an intense central sclerosis that occupies the en...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165(2004)128<1046:SMCOTP>2.0.CO;2

    authors: Fadare O,Hileeto D,Gruddin YL,Mariappan MR

    更新日期:2004-09-01 00:00:00

  • A simple and reliable rapid methenamine silver stain for Pneumocystis carinii and fungi.

    abstract::A modification to a rapid hot methenamine silver stain is described that shortens the silver staining step of the procedure to one to five minutes. It also eliminates the requirement to manipulate hot solutions. ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Shimono LH,Hartman B

    更新日期:1986-09-01 00:00:00

  • Adult rhabdomyoma: ultrastructure and immunocytochemistry.

    abstract::Adult rhabdomyoma is a benign, highly differentiated tumor of skeletal muscle. We observed transverse tubules and triads beside myofilaments in a rhabdomyoma from the submandibular area of a 66-year-old woman. Several types of muscle cells were present. In one, mitochondria abounded; in another, muscle filaments predo...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Warner TF,Goell W,Sundharadas M,Falk VS

    更新日期:1981-11-01 00:00:00

  • Trainable immunohistochemical HER2/neu image analysis: a multisite performance study using 260 breast tissue specimens.

    abstract:CONTEXT:Aperio Technologies, Inc (Vista, California) provides a new immunohistochemistry (IHC) HER2 Image Analysis (IA) system that allows tuning of the intensity thresholds of the HER2/ neu scoring scheme to adapt to the staining characteristics of different reagents. OBJECTIVE:To compare the trainable IHC HER2 IA sy...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/2010-0418-OAR1.1

    authors: Nassar A,Cohen C,Agersborg SS,Zhou W,Lynch KA,Albitar M,Barker EA,Vanderbilt BL,Thompson J,Heyman ER,Lange H,Olson A,Siddiqui MT

    更新日期:2011-07-01 00:00:00

  • Molecular characterization of colorectal neoplasia in translational research.

    abstract:OBJECTIVE:To present recent advances in the use of molecular markers in diagnosis, in prognosis, in early detection, in novel therapies, and in understanding the molecular pathogenesis of colorectal neoplasia. DATA AND LITERATURE SOURCES:A review of studies of molecular markers in colorectal neoplasia, published in En...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/0003-9985(2001)125<0091:MCOCNI>2.0.CO;2

    authors: Grizzle WE,Manne U,Jhala NC,Weiss HL

    更新日期:2001-01-01 00:00:00

  • Changes in participant performance in the "test-taking" environment: observations from the 2006 College of American Pathologists Gynecologic Cytology Proficiency Testing Program.

    abstract:CONTEXT:Because the consequences of making an interpretive error on a proficiency test are more severe than those made on an educational challenge, the same slide may exhibit different performance characteristics in the 2 different settings. OBJECTIVE:The results of the 2006 College of American Pathologists Gynecologi...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165-133.2.279

    authors: Hughes JH,Bentz JS,Fatheree L,Souers RJ,Wilbur DC,Cytopathology Resource Committee, College of American Pathologists.

    更新日期:2009-02-01 00:00:00

  • Identification of dense deposit disease: a report for the International Study of Kidney Diseases in Children.

    abstract::The fluorescent dye thioflavin T stains intensely the deposits in dense deposit disease and can be used for identification purposes. Comparison of thioflavin T staining with electron microscopy was carried out in 25 patients and showed excellent congruity. Thioflavin T is much easier to use, but is less specific than ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Churg J,Duffy JL,Bernstein J

    更新日期:1979-02-01 00:00:00

  • Accuracy of Burkitt lymphoma diagnosis in constrained pathology settings: importance to epidemiology.

    abstract:CONTEXT:Burkitt lymphoma (BL) is endemic in Uganda and because of the high incidence, diagnosis is often presumed during clinical care and epidemiologic studies. OBJECTIVES:To assess the accuracy of the clinical and the local pathology diagnosis of BL as assessed by an outside pathology review diagnosis and to underst...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/2009-0443-EP.1

    authors: Ogwang MD,Zhao W,Ayers LW,Mbulaiteye SM

    更新日期:2011-04-01 00:00:00

  • Protocol for the examination of specimens from patients with carcinoma of the ampulla of Vater: a basis for checklists. Cancer Committee, College of American Pathologists.

    abstract::A protocol for the pathologic examination and reporting of specimens from patients with carcinoma of the ampulla of Vater has been developed by the Cancer Committee of the College of American Pathologists. The protocol incorporates all basic pathology data of diagnostic and prognostic significance appropriate for the ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Compton CC

    更新日期:1997-07-01 00:00:00

  • Multiparameter flow cytometry in the diagnosis and management of acute leukemia.

    abstract:CONTEXT:Timely and accurate diagnosis of hematologic malignancies is crucial to appropriate clinical management. Acute leukemias are a diverse group of malignancies with a range of clinical presentations, prognoses, and preferred treatment protocols. Historical classification systems relied predominantly on morphologic...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/2010-0387-RAR.1

    authors: Peters JM,Ansari MQ

    更新日期:2011-01-01 00:00:00

  • Forensic pathology and the autopsy.

    abstract::Questionnaires sent to representative medicolegal jurisdictions in the United States showed that medicolegal necropsies comprise a substantial proportion of the total number of autopsies performed. Qualitative differences between customary hospital autopsies and their forensic counterparts include autopsy bias, the im...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Hirsch CS

    更新日期:1984-06-01 00:00:00

  • Lymphovascular invasion in micropapillary urothelial carcinoma: a study of 22 cases.

    abstract:CONTEXT:Micropapillary urothelial carcinoma (MPUC) is a known aggressive variant of urothelial carcinoma. However, the reasons for its aggressiveness remain unclear. OBJECTIVE:To investigate the frequency of lymphovascular invasion in 22 cases of MPUC. DESIGN:Consecutive tissue sections were stained with D2-40 and CD...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2011-0463-OA

    authors: McQuitty E,Ro JY,Truong LD,Shen SS,Zhai Q,Ayala AG

    更新日期:2012-06-01 00:00:00

  • Mucogenic cells of congenital adenomatoid malformation of lung.

    abstract::Findings of a histochemical and ultrastructural study of the mucogenic cells of congenital adenomatoid malformation of lung indicate that these cells share features with goblet cells of bronchial or intestinal origin and do not indicate a similarity to normal gastric epithelium or glands, as has been previously sugges...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Daroca PJ Jr

    更新日期:1979-05-01 00:00:00

  • Defining Normal Healthy Term Newborn Automated Hematologic Reference Intervals at 24 Hours of Life.

    abstract:CONTEXT.—:Automated analyzers have advanced the field of clinical hematology, mandating updated complete blood count (CBC) reference intervals (RIs) to be clinically useful. Contemporary newborn CBC RI publications are mostly retrospective, which some authors have cited as one of their cardinal limitations and recommen...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2019-0444-OA

    authors: Ianni B,McDaniel H,Savilo E,Wade C,Micetic B,Johnson S,Gerkin R

    更新日期:2020-04-16 00:00:00

  • Solitary cavernous hemangioma of small intestine. Case report and literature review.

    abstract::We describe a 14-year-old boy with a solitary cavernous hemangioma in the proximal small intestine that caused recalcitrant iron deficiency anemia beginning at 3 years of age. After a number of attempts to ascertain the cause of the anemia were unsuccessful, the vascular tumor was ultimately diagnosed in the jejunum, ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Boyle L,Lack EE

    更新日期:1993-09-01 00:00:00

  • Number of levels needed for diagnosis of cervical biopsies.

    abstract:CONTEXT:Three levels of histologic sections are routinely prepared for small biopsies in many surgical pathology laboratories. The first level is superficial and may not be representative of the entire biopsy, and may therefore represent wasted resources and time for technologists and pathologists alike. OBJECTIVE:To ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2002)126<1205:NOLNFD>2.0.CO;2

    authors: Luo YV,Prihoda TJ,Sharkey FE

    更新日期:2002-10-01 00:00:00

  • Liability issues with the Papanicolaou smear: general legal background.

    abstract::All diagnosticians are aware of malpractice and its implications. To allay justifiable fears, familiarity with legal terminology and legal procedures is invaluable. In this article, the ramifications of malpractice coverage, the tenets of risk management, and the proceedings related to a malpractice lawsuit are clarif...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Kline TJ

    更新日期:1997-03-01 00:00:00

  • Interobserver Variability in the Diagnosis of Uterine High-Grade Endometrioid Carcinoma.

    abstract:CONTEXT:-Low interobserver diagnostic agreement exists among high-grade endometrial carcinomas. OBJECTIVE:-To evaluate diagnostic variability in International Federation of Gynecology and Obstetrics (FIGO) grade 3 endometrioid adenocarcinoma (G3EC) in 2 different sign-out practices. DESIGN:-Sixty-six G3EC cases were ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2015-0220-OA

    authors: Thomas S,Hussein Y,Bandyopadhyay S,Cote M,Hassan O,Abdulfatah E,Alosh B,Guan H,Soslow RA,Ali-Fehmi R

    更新日期:2016-08-01 00:00:00

  • Primary cutaneous aspergillosis mimicking dermatophytosis.

    abstract::We recently reviewed a skin biopsy specimen obtained from a child with acute monocytic leukemia that demonstrated abundant mycelia present within a keratin plug of a hair follicle, a granulomatous dermal inflammatory infiltrate, and focal dermal invasion by fungi. These histologic findings were suggestive of an invasi...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Googe PB,DeCoste SD,Herold WH,Mihm MC Jr

    更新日期:1989-11-01 00:00:00

  • Pseudomyogenic Hemangioendothelioma (Epithelioid Sarcoma-Like Hemangioendothelioma).

    abstract::Pseudomyogenic hemangioendothelioma (PMH) is a rare vascular tumor that presents more frequently in young adults and has a male predominance. It is usually located in the superficial or deep soft tissues of the extremities, but concurrent bone involvement can be present. In approximately two-thirds of patients this di...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2018-0395-RS

    authors: Caballero GA,Roitman PD

    更新日期:2020-04-01 00:00:00

  • Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical study.

    abstract:CONTEXT:The pathogenesis of respiratory epithelial adenomatoid hamartoma (REAH) and inverted papilloma (IP) is poorly understood, especially compared with sinonasal adenocarcinoma (SNAC). One feature of malignant glandular lesions is loss of the basal/myoepithelial layer. The immunophenotype of the basal/myoepithelial ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2007)131[530:MCICSR]2.0.CO;2

    authors: Ozolek JA,Barnes EL,Hunt JL

    更新日期:2007-04-01 00:00:00

  • Neuronal hypertrophy in acute appendicitis.

    abstract:OBJECTIVE:The pathogenesis of appendicitis remains poorly understood. However, there is increasing evidence of involvement of the enteric nervous system in immune regulation and in inflammatory responses. This study was set up to characterize the status of the enteric nervous system in normal and in inflamed appendixes...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2000)124<1429:NHIAA>2.0.CO;2

    authors: Xiong S,Puri P,Nemeth L,O'Briain DS,Reen DJ

    更新日期:2000-10-01 00:00:00

  • Endomyocardial fibrosis with calcification of the myocardium.

    abstract::A case of endomyocardial fibrosis with intramyocardial calcification was characterized by symptoms of restrictive cardiomyopathy resembling constrictive pericarditis. Pathological findings were typical of those found in classical Davies' disease, originally encountered and described in Uganda. ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Koestner AW,Bush CA,Baba N

    更新日期:1978-08-01 00:00:00

  • Use of a monoclonal antibody to detect Pneumocystis carinii in induced sputum and bronchoalveolar lavage fluid by immunoperoxidase staining.

    abstract::We evaluated the utility of a monoclonal antibody that recognizes Pneumocystis carinii as a diagnostic tool in specimens of bronchoalveolar lavage fluid and sputum from patients in whom a diagnosis of P carinii pneumonia was being considered. In addition to routine processing for diagnosis by morphologic recognition o...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Blumenfeld W,Kovacs JA

    更新日期:1988-12-01 00:00:00

  • Primary renal synovial sarcoma confirmed by cytogenetic analysis: a lesion distinct from sarcomatoid renal cell carcinoma.

    abstract::Primary synovial sarcoma rarely originates in the renal parenchyma. When this occurs, origin of this unusual tumor type has been the subject of debate in the literature, with a suggestion that previously reported cases may be more correctly described as renal cell carcinoma with sarcomatoid dedifferentiation. Synovial...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2005)129<238:PRSSCB>2.0.CO;2

    authors: Shannon BA,Murch A,Cohen RJ

    更新日期:2005-02-01 00:00:00

  • Common Data Elements for Muscle Biopsy Reporting.

    abstract:CONTEXT:There is no current standard among myopathologists for reporting muscle biopsy findings. The National Institute of Neurological Disorders and Stroke has recently launched a common data element (CDE) project to standardize neuromuscular data collected in clinical reports and to facilitate their use in research. ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2014-0453-OA

    authors: Dastgir J,Rutkowski A,Alvarez R,Cossette SA,Yan K,Hoffmann RG,Sewry C,Hayashi YK,Goebel HH,Bonnemann C,Lawlor MW

    更新日期:2016-01-01 00:00:00

  • Metanephric adenoma-like tumors of the kidney: report of 3 malignancies with emphasis on discriminating features.

    abstract:BACKGROUND:Metanephric adenoma is a very rare benign renal tumor; only 80 well-documented cases have been reported to date. We have seen several renal tumors that were originally incorrectly diagnosed as metanephric adenoma. DESIGN:We present 3 unusual renal tumors (2 primary and 1 metastatic), each of which illustrat...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(1999)123<0415:MALTOT>2.0.CO;2

    authors: Pins MR,Jones EC,Martul EV,Kamat BR,Umlas J,Renshaw AA

    更新日期:1999-05-01 00:00:00

  • HER2/neu in Endometrial Cancer: A Promising Therapeutic Target With Diagnostic Challenges.

    abstract:CONTEXT:In the era of targeted cancer therapy, there is growing interest in developing novel therapeutic strategies against endometrial carcinoma, especially its most biologically aggressive variant, serous adenocarcinoma. Several publications have demonstrated that a significant proportion of uterine serous carcinomas...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2012-0416-RA

    authors: Buza N,Roque DM,Santin AD

    更新日期:2014-03-01 00:00:00