Hypermethylation of the M27beta (DXS255) locus in chronic B-cell leukaemia.

abstract：:Mantle cell lymphoma (MCL) is an incurable mature B cell proliferation, combining the unfavourable clinical features of aggressive and indolent lymphomas. The blastic variant of MCL has an even worse prognosis and new treatment options are clearly needed. We analysed the effects of BL22, an immunotoxin composed of the...

journal_title：British journal of haematology

authors： Bogner C,Dechow T,Ringshausen I,Wagner M,Oelsner M,Lutzny G,Licht T,Peschel C,Pastan I,Kreitman RJ,Decker T

更新日期：2010-01-01 00:00:00

abstract：:Podocalyxin-like protein (PCLP) is a sialomucin-type membrane protein structurally related to CD34 and endoglycan. It was first described in glomerular podocytes and endothelial cells. In mice, PCLP is present in haemangioblasts, and in both chicken and mice it is a marker of early haematopoietic stem cells and lineag...

journal_title：British journal of haematology

authors： Kerosuo L,Juvonen E,Alitalo R,Gylling M,Kerjaschki D,Miettinen A

更新日期：2004-03-01 00:00:00

abstract：:A recombinant bispecific single-chain fragment variable antibody (bsscFv), directed against the B-cell antigen CD19 and the low affinity Fc-receptor FcgammaRIII (CD16), was designed for use in the treatment of patients with leukaemias and lymphomas. The Fc-portions of whole antibodies were deliberately eliminated in t...

journal_title：British journal of haematology

authors： Bruenke J,Barbin K,Kunert S,Lang P,Pfeiffer M,Stieglmaier K,Niethammer D,Stockmeyer B,Peipp M,Repp R,Valerius T,Fey GH

更新日期：2005-07-01 00:00:00

abstract：:Globin synthesis was studied in four Negro families including 10 members with Hb A-HPFH and four with Hb S-HPFH. The beta/alpha specific activity ratios in 10 of these HPFH heterozygotes were similar to those of the control group. In two patients with Hb A-HPFH, the beta/alpha ratio was slightly decreased in one (0.84...

journal_title：British journal of haematology

authors： Friedman S,Schwartz E,Ahern E,Ahern V

更新日期：1976-03-01 00:00:00

abstract：:Interleukin-12 (IL-12), a heterodimeric cytokine with potent biological activity, was evaluated for effects on proliferation of human immature progenitor cells in vitro. In vitro proliferation of 5-FU-resistant CD34+ (G0) peripheral blood stem cells (PBSC) in response to sequential cytokine stimulation was examined in...

journal_title：British journal of haematology

authors： Grafte-Faure S,Leveque C,Vasse M,Soria C,Vannier JP

更新日期：1999-04-01 00:00:00

abstract：:Simultaneous evaluation of coagulation and fibrinolysis facilitates an overall understanding of normal and pathological haemostasis. We established an assay for assessing clot formation and fibrinolysis simultaneously using clot waveform analysis by the trigger of a mixture of activated partial thromboplastin time rea...

journal_title：British journal of haematology

authors： Nogami K,Matsumoto T,Sasai K,Ogiwara K,Arai N,Shima M

更新日期：2019-11-01 00:00:00

abstract：:t(11;18)(q21;q21) has been recognized as a characteristic chromosomal translocation in mucosa-associated lymphoid tissue (MALT)-type lymphoma, and recent studies have demonstrated that this translocation results in the chimaeric transcript of API2 (apoptosis inhibitor 2)-MALT1 (mucosa-associated lymphoid tissue lympho...

journal_title：British journal of haematology

authors： Yonezumi M,Suzuki R,Suzuki H,Yoshino T,Oshima K,Hosokawa Y,Asaka M,Morishima Y,Nakamura S,Seto M

更新日期：2001-12-01 00:00:00

abstract：:Heterozygosity for a C8524T transition in the protein C gene converting Ser270(TCG) to Leu(TTG) in the protease domain was identified in a family with venous thrombosis. The mutation was associated with parallel reduction in plasma levels of protein C anticoagulant activity and protein C antigen, which is consistent w...

journal_title：British journal of haematology

authors： Lind B,Koefoed P,Thorsen S

更新日期：2001-06-01 00:00:00

abstract：:Due to the development of neurological toxicity and resistance to methotrexate (MTX), other antifolates have been evaluated for its potential replacement in the treatment of childhood acute lymphoblastic leukaemia (ALL). Aminopterin (AMT) has been suggested to provide clinical advantages over MTX and other antifolates...

journal_title：British journal of haematology

authors： Kang MH,Harutyunyan N,Hall CP,Papa RA,Lock RB

更新日期：2009-05-01 00:00:00

abstract：:Allogeneic haematopoietic stem cell transplantation (HSCT) after a reduced-intensity conditioning (RIC) regimen with fludarabine, melphalan and alemtuzmab is an effective therapy for haematological malignancies. Alemtuzumab, a monoclonal antibody against CD52, a glycosylphosphatidylinositol-anchor-bound surface protei...

journal_title：British journal of haematology

authors： Woelfinger P,Epp K,Schaefer L,Kriege D,Theobald M,Bopp T,Wagner-Drouet EM

更新日期：2020-10-01 00:00:00

abstract：:Eight patients with aplastic anaemia associated with dyskeratosis congenita received allogeneic marrow grafts from either HLA-identical siblings (six patients) or HLA-matched unrelated donors (two patients). Patients who received marrow from HLA-identical siblings were conditioned with cyclophosphamide (140-200 mg/kg)...

journal_title：British journal of haematology

authors： Langston AA,Sanders JE,Deeg HJ,Crawford SW,Anasetti C,Sullivan KM,Flowers ME,Storb R

更新日期：1996-03-01 00:00:00

abstract：:Resistance to the anticoagulant effects of activated protein C (APC) is now considered the most prevalent cause of inherited thrombophilia. The great majority of patients with activated protein C resistance (APCR) have a missense mutation in the factor V molecule (factor V Leiden, FVR506Q) resulting in defective inact...

journal_title：British journal of haematology

authors： Liebman HA,Sutherland D,Bacon R,McGehee W

更新日期：1996-12-01 00:00:00

abstract：:A retrospective study of 37 patients with haematological malignancy (21 acute myeloid leukaemia, 11 acute lymphoid leukaemia, two lymphoma, two hairy cell leukaemia, one Hodgkin's disease) and histologically documented mucormycosis was conducted to evaluate the clinical characteristics and ascertain the factors which ...

journal_title：British journal of haematology

authors： Pagano L,Ricci P,Tonso A,Nosari A,Cudillo L,Montillo M,Cenacchi A,Pacilli L,Fabbiano F,Del Favero A

更新日期：1997-11-01 00:00:00

abstract：:Most haemolytic disease is mediated by immunoglobulin G (IgG) antibodies and leads to red blood cell destruction outside of the circulatory system. However, rare syndromes, such as paroxysmal cold haemoglobinuria, show IgG antibodies causing intravascular destruction. Haemolysis may also occur because of immunoglobuli...

journal_title：British journal of haematology

authors： Gertz MA

更新日期：2007-08-01 00:00:00

abstract：:Primary non-engraftment or early rejection after transplantation of haematopoietic stem cells represent life-threatening complications of allogeneic stem cell transplantation. Management of early graft failure has been problematic, as the risk of fatal infectious complications increases with the time of pancytopenia a...

journal_title：British journal of haematology

authors： Schlegel PG,Eyrich M,Bader P,Handgretinger R,Lang P,Niethammer D,Klingebiel T

更新日期：2000-11-01 00:00:00

abstract：:The inducibility of glycosyl-phosphatidylinositol (GPI)-anchored proteins on affected paroxysmal nocturnal haemoglobinuria (PNH) neutrophils (PMN) after both in vitro and in vivo stimulation was investigated. Fc gamma R-III (CD16), decay-accelerating factor (DAF/CD55) and 20 kD homologous restriction factor (HRF20/CD5...

journal_title：British journal of haematology

authors： Ninomiya H,Muraki Y,Shibuya K,Nagasawa T,Abe T

更新日期：1993-07-01 00:00:00

abstract：:Based on the morphological appearances of the bone marrow and peripheral blood, 43 patients with dysmyelopoietic syndromes were categorized into four types: refractory anaemia with excess of blasts, chronic myelomonocytic leukaemia, primary acquired sideroblastic anaemia and refractory anaemia with cellular marrow, wi...

journal_title：British journal of haematology

authors： Cazzola M,Barosi G,Berzuini C,Dacco M,Orlandi E,Stefanelli M,Ascari E

更新日期：1982-01-01 00:00:00

abstract：:Post-transplant lymphoproliferative disorder (PTLD) after haemopoietic stem cell transplantation is a serious complication that occurs in 8-22% of patients with high-risk factors. We retrospectively investigated tolerance and efficacy of humanized anti-CD20 monoclonal antibody (rituximab) as first-line treatment in 12...

journal_title：British journal of haematology

authors： Faye A,Quartier P,Reguerre Y,Lutz P,Carret AS,Dehée A,Rohrlich P,Peuchmaur M,Matthieu-Boué A,Fischer A,Vilmer E

更新日期：2001-10-01 00:00:00

abstract：:We describe the characterization of a novel 7.9 kb deletion that eliminated one of the duplicated alpha-globin genes, causing an alpha+-thalassaemia phenotype in two independent carriers of Suriname-Indian origin. The molecular characterization of the deletion breakpoint fragment revealed neither involvement of Alu re...

journal_title：British journal of haematology

authors： Harteveld CL,van Delft P,Wijermans PW,Kappers-Klunne MC,Weegenaar J,Losekoot M,Giordano PC

更新日期：2003-01-01 00:00:00

abstract：:Antithrombin III (AT III) activity has been measured in 9669 healthy blood donors (5525 male and 4144 female). The distribution of AT III is approximately 'normal' with mean 105.6 IU/dl and standard deviation 11.2; however, definite age and sex related variations are evident. Pre-menopausal females have lower mean AT ...

journal_title：British journal of haematology

authors： Tait RC,Walker ID,Islam SI,McCall F,Conkie JA,Mitchell R,Davidson JF

更新日期：1993-07-01 00:00:00

abstract：:Thrombocytopenia is common (40-65%) and potentially serious in myelodysplastic syndromes (MDS). A systematic review was conducted to determine the safety and efficacy of adding a thrombopoietin-receptor (THPO-R) agonist to standard MDS treatment. MEDLINE, EMBASE and CENTRAL databases were searched. We included randomi...

journal_title：British journal of haematology

authors： Prica A,Sholzberg M,Buckstein R

更新日期：2014-12-01 00:00:00

abstract：:An examination of HLA antigens in 72 unrelated Caucasian subjects with pernicious anaemia (PA) has revealed no significant association of any HLA-A or B genes with the disease. These data do not confirm the previous reports in the literature which had suggested an increased frequency of the B7 and/or A3 antigen among ...

journal_title：British journal of haematology

authors： Wright JP,Callender ST,Grumet FC,Payne RO,Taylor KB

更新日期：1977-05-01 00:00:00

abstract：:Pulmonary hypertension (PH) in patients with sickle cell disease (SCD) is linked to intravascular haemolysis, impaired nitric oxide bioavailability, renal dysfunction, and early mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthases (NOS), is associated with vascular disease i...

journal_title：British journal of haematology

authors： Kato GJ,Wang Z,Machado RF,Blackwelder WC,Taylor JG 6th,Hazen SL

更新日期：2009-05-01 00:00:00

abstract：:This review will focus on the strengths and limitations associated with the current standard of care for primary prevention of ischaemic strokes in children with sickle cell anaemia (SCA) - transcranial Doppler ultrasound (TCD) screening followed by regular blood transfusion therapy when TCD measurement is above a thr...

journal_title：British journal of haematology

authors： Jordan LC,Casella JF,DeBaun MR

更新日期：2012-04-01 00:00:00

abstract：:Colony-forming cells of the granulocytic/macrophage ( CFCGM ) and eosinophilic ( CFCEo ) series were grown from bone marrow and/or peripheral blood of 20 patients with persistent eosinophilia mainly due to helminthic diseases and of 17 patients without eosinophilia. The semi-solid culture technique of haemopoietic cel...

journal_title：British journal of haematology

authors： Kern P,Dietrich M

更新日期：1984-05-01 00:00:00

abstract：:In an attempt to develop a model system for analysing iron metabolism in a relatively homogeneous population of early red cell precursors, the intracellular distribution of 59Fe was examined in Friend murine erythroleukaemic cells after induction of haemoglobin synthesis with dimethylsulphoxide. After incubation of th...

journal_title：British journal of haematology

authors： Peto TE,Rutherford TR,Thompson JL,Weatherall DJ

更新日期：1983-08-01 00:00:00

abstract：:We report on quantitative analyses of C5b-9 binding to target red blood cells (RBC) lysed through the action of drug (nomifensine)-dependent antibodies (ddab) and anti-RBC antibodies (warm plus cold agglutinins). Immunoradiometric assays showed that, at any given degree of haemolysis, more C5b-9 was bound to cells sen...

journal_title：British journal of haematology

authors： Salama A,Mueller-Eckhardt C,Boschek B,Bhakdi S

更新日期：1987-02-01 00:00:00

abstract：:Myeloid neoplasms derive from the pathological clonal expansion of an abnormal stem cell and span a diverse spectrum of phenotypes including acute myeloid leukaemia (AML), myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS). Expansion of myeloid blasts with suppression of normal haematopoiesis is th...

journal_title：British journal of haematology

authors： Loh ML

更新日期：2011-03-01 00:00:00

abstract：:The combination of bendamustine, bortezomib and dexamethasone (BBD) was evaluated as a first-line therapy for multiple myeloma. The original treatment regimen of bendamustine 80 mg/m2 , days 1, 4; bortezomib 1·3 mg/m2 , days 1, 4, 8, 11; dexamethasone 40 mg, days 1, 2, 3, 4 on a 28-day cycle (up to 8 cycles) was effic...

journal_title：British journal of haematology

authors： Berdeja JG,Bauer T,Arrowsmith E,Essell J,Murphy P,Reeves JA Jr,Boccia RV,Donnellan W,Flinn I

更新日期：2017-04-01 00:00:00

abstract：:Thrombocytopenia absent radii (TAR) syndrome is clearly defined by the combination of radial aplasia and reduced platelet counts. The genetics of TAR syndrome has recently been resolved and comprises a microdeletion on Chromosome 1 including the RBM8A gene and a single nucleotide polymorphism (SNP) either at the 5' un...

journal_title：British journal of haematology

authors： Manukjan G,Bösing H,Schmugge M,Strauß G,Schulze H

更新日期：2017-11-01 00:00:00