Soluble ecto-domain mutant of thyrotropin (TSH) receptor incapable of binding TSH neutralizes the action of thyroid-stimulating antibodies from Graves' patients.

abstract：:Transforming growth factor-alpha (TGF alpha) has been localized to the anterior pituitary, specifically to the lactotroph and somatotroph cell populations, by our previous studies. Since pituitary lactotrophs are known to undergo growth in response to estrogens, we have used an estradiol-induced pituitary hyperplasia/...

journal_title：Endocrinology

authors： Borgundvaag B,Kudlow JE,Mueller SG,George SR

更新日期：1992-06-01 00:00:00

abstract：:The secretion of LH, PRL, and cortisol was investigated in 4 sexually mature female rhesus macaques with cardiac catheters protected by tethers. Based on endocrine parameters, all 4 of the animals ovulated within 2 months from the time they were tethered, and regular menstrual cycles of 24-34 days were observed. The c...

journal_title：Endocrinology

authors： Norman RL,Lindstrom SA,Bangsberg D,Ellinwood WE,Gliessman P,Spies HG

更新日期：1984-07-01 00:00:00

abstract：:Little is known about the mechanisms of action of polypeptide hormones on chromatin structure and nuclear function. We have employed micrococcal nuclease to examine the effect of TSH on the accessibility of DNA in thyroid nuclei. Brief digestion of nuclear suspensions with 0.05-0.2 U/ml micrococcal nuclease at 26-28 C...

journal_title：Endocrinology

authors： Abe Y,Cooper E,Spaulding SW

更新日期：1982-06-01 00:00:00

abstract：:To study the role of the epithelial calcium channel transient receptor potential vanilloid type 6 (TRPV6) and the calcium-binding protein calbindin-D9k in intestinal calcium absorption, TRPV6 knockout (KO), calbindin-D9k KO, and TRPV6/calbindin-D(9k) double-KO (DKO) mice were generated. TRPV6 KO, calbindin-D9k KO, and...

journal_title：Endocrinology

authors： Benn BS,Ajibade D,Porta A,Dhawan P,Hediger M,Peng JB,Jiang Y,Oh GT,Jeung EB,Lieben L,Bouillon R,Carmeliet G,Christakos S

更新日期：2008-06-01 00:00:00

abstract：:Activins stimulate FSH synthesis and secretion by pituitary gonadotrope cells. Activin A induction of porcine and murine FSHβ (Fshb) gene transcription in immortalized gonadotropes is dependent on homolog of Drosophila mothers against decapentaplegic (SMAD) proteins as well as the forkhead transcription factor L2 (FOX...

journal_title：Endocrinology

authors： Lamba P,Wang Y,Tran S,Ouspenskaia T,Libasci V,Hébert TE,Miller GJ,Bernard DJ

更新日期：2010-11-01 00:00:00

abstract：:Cholera toxin (CT) injected ip on day 1 (day of ovulation) of the 4-day hamster estrous cycle, when circulatory progesterone is high and estrogen low, induced a massive uterine decidual reaction, a progesterone-dependent growth normally triggered by the implanting blastocyst. However, CT injected ip on day 3, when cir...

journal_title：Endocrinology

authors： Alleva JJ,Kenimer JG,Jordan AW,Lamanna C

更新日期：1983-06-01 00:00:00

abstract：:The aim of our study was to isolate and identify novel proteins that are involved in the process of ovulation. To achieve this goal we used the technique of proteome analysis. Comparison of ovary protein patterns, obtained by high resolution two-dimensional gel electrophoresis from recombinant FSH (rFSH)- and rFSH + h...

journal_title：Endocrinology

authors： Brockstedt E,Peters-Kottig M,Badock V,Hegele-Hartung C,Lessl M

更新日期：2000-07-01 00:00:00

abstract：:Estrogen deficiency causes bone loss by increasing the number of bone-resorbing osteoclasts. Selective p38α MAPK inhibitors prevent bone-wasting effects of estrogen withdrawal but implicated mechanisms remain to be identified. Here, we show that inactivation of the p38α-encoding gene in osteoblast lineage cells with t...

journal_title：Endocrinology

authors： Thouverey C,Caverzasio J

更新日期：2015-12-01 00:00:00

abstract：:The enteroendocrine and enteric nervous systems convey signals through an overlapping network of regulatory peptides that act either as circulating hormones or as localized neurotransmitters within the gastrointestinal tract. Because recent studies invoke an important role for vasoactive intestinal peptide (VIP) as a ...

journal_title：Endocrinology

authors： Yusta B,Holland D,Waschek JA,Drucker DJ

更新日期：2012-06-01 00:00:00

abstract：:With advancing age, 60-80% of the follicles of the mouse thyroid gland turn "cold", i.e. they lose their normal capacity to iodinate thyroglobulin (Tgb). Cold follicles are morphologically characterized by their large size, by deeply periodic acid-Schiff-stained colloid and by flat epithelial cells. We investigated th...

journal_title：Endocrinology

authors： Gerber H,Peter HJ,Studer H

更新日期：1987-05-01 00:00:00

abstract：:The lipid phosphatase, phosphatase and tensin homolog (PTEN), is a key element in controlling cell growth and survival and has a well established role as tumor suppressor protein in many neoplasia. Several data indicate that silencing of PTEN gene expression may be relevant in follicular thyroid cell transformation. T...

journal_title：Endocrinology

authors： Tell G,Pines A,Arturi F,Cesaratto L,Adamson E,Puppin C,Presta I,Russo D,Filetti S,Damante G

更新日期：2004-10-01 00:00:00

abstract：:A parotid hormone (PH-A beta) has been isolated and purified from porcine parotid glands. The biological effect of the hormone is the stimulation of a dentinal fluid transport (DFT) in molar teeth of rats. The method for purifying the PH-A beta includes: extraction at pH 7 and 5, ultrafiltration through Amicon membran...

journal_title：Endocrinology

authors： Tieche JM,Leonora J,Steinman RR

更新日期：1980-06-01 00:00:00

abstract：:Plasma chromogranin-A (CgA) concentrations correlate with severe cardiovascular diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an antiadrenergic/nitric oxide-cGMP mediated mechanism. Whether these phenomena are related is unknown. We here investigated whether and to what extent ...

journal_title：Endocrinology

authors： Pasqua T,Corti A,Gentile S,Pochini L,Bianco M,Metz-Boutigue MH,Cerra MC,Tota B,Angelone T

更新日期：2013-09-01 00:00:00

abstract：:The pharmacokinetics of TRH and its metabolite deamido-TRH (TRH-OH) were evaluated and compared. After a 60- to 90-min infusion of the appropriate peptide into rats, the MCR, half-life of disappearance (t 1/2), and volume of distribution were calculated. The MCR of TRH averaged 4 ml/min, whereas that of TRH-OH was 6.5...

journal_title：Endocrinology

authors： Safran M,Wu CF,Matys R,Alex S,Emerson CH

更新日期：1984-09-01 00:00:00

abstract：:Homogenates from male ddy mouse sublingual glands were incubated with 100 nM [125I]rT3 in the presence of 2 mM dithiothreitol (DTT). Metabolites were analyzed by HPLC or Dowex-50 minicolumn assay. 3,3'-Diiodothyronine and I- were the only appreciable products. Iodide release from rT3 was compatible with the enzymatic ...

journal_title：Endocrinology

authors： Tanaka K,Imura H

更新日期：1993-03-01 00:00:00

abstract：:Thyroid hormones increase bone turnover in vivo and stimulate bone resorption in vitro. Clinical states associated with excess circulating thyroid hormone levels are known to produce osteoporosis. To determine the effect of T3 on bone resorption, we used an isolated rat osteoclast bone resorption assay in the absence ...

journal_title：Endocrinology

authors： Britto JM,Fenton AJ,Holloway WR,Nicholson GC

更新日期：1994-01-01 00:00:00

abstract：:We looked for the presence of vitamin D-dependent intestinal calcium binding protein (CaBP), relative molecular mass (mol wt) about 10,000, in kidneys of mammals, birds, and reptiles, and compared the localization of this 10,000 mol wt CaBP with the localization of the 28,000 mol wt vitamin D-dependent CaBP. Antiserum...

journal_title：Endocrinology

authors： Rhoten WB,Bruns ME,Christakos S

更新日期：1985-08-01 00:00:00

abstract：:GH secretion is markedly blunted in obesity; however, the mechanism(s) mediating this response remains to be elucidated. In the present study we examined the involvement of the two hypothalamic GH-regulatory hormones, GH-releasing factor (GRF) and somatostatin (SRIF), using the genetically obese male Zucker rat. Spont...

journal_title：Endocrinology

authors： Tannenbaum GS,Lapointe M,Gurd W,Finkelstein JA

更新日期：1990-12-01 00:00:00

abstract：:Marked development of the mammary parenchyma (ducts, lobules, and alveoli) occurs during the last third of the 115-day gestation period in the gilt. These changes in the mammary gland are temporally correlated with elevated blood levels of relaxin, estrogen, and progesterone. We recently demonstrated that relaxin play...

journal_title：Endocrinology

authors： Winn RJ,Baker MD,Merle CA,Sherwood OD

更新日期：1994-09-01 00:00:00

abstract：:The role of the paraventricular nucleus-dorsal anterior hypothalamus (PVN-DAHA) in the control of anterior pituitary gland secretion of FSH and LH in castrated male and female rats was examined. Bilateral radiofrequency lesions of the PVN-DAHA in chronically ovariectomized (OVX) rats lowered plasma FSH levels by 33% (...

journal_title：Endocrinology

authors： Lumpkin MD,McCann SM

更新日期：1984-12-01 00:00:00

abstract：:Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups we...

journal_title：Endocrinology

authors： Jaimes-Hoy L,Gutiérrez-Mariscal M,Vargas Y,Pérez-Maldonado A,Romero F,Sánchez-Jaramillo E,Charli JL,Joseph-Bravo P

更新日期：2016-08-01 00:00:00

abstract：:The purpose of this study was to examine the relative roles of FSH and LH in stimulating testicular inhibin secretion in the male rhesus monkey. Recombinant human (rh) FSH and rhCG were used as the gonadotropic stimuli, and juvenile rhesus monkeys, in which the endocrine activity of the pituitary-testicular axis was b...

journal_title：Endocrinology

authors： Majumdar SS,Winters SJ,Plant TM

更新日期：1997-04-01 00:00:00

abstract：:Estrogen receptor alpha and beta proteins (ERalpha and ERbeta) at various stages of development of the rat mammary gland were quantified by Western blotting. ERalpha and ERbeta recombinant proteins were used as standards, and their molar concentrations were measured by ligand binding assays. In 3-week-old pregnant, la...

journal_title：Endocrinology

authors： Saji S,Sakaguchi H,Andersson S,Warner M,Gustafsson J

更新日期：2001-07-01 00:00:00

abstract：:The guinea pig adrenal cortex is grossly composed of two regions: an outer, yellow zone and an inner, brown zone. These zones, which represent 33% and 66% of the total adrenocortical volume, respectively, can be separated by blunt dissection. It has been previously reported that specific pregnenolone and pregnenolone ...

journal_title：Endocrinology

authors： Strott CA,Goff AK,Lyons CD

更新日期：1981-12-01 00:00:00

abstract：:To examine the role of androgen receptor (AR) in Sertoli cells (SC), we used a SC-specific AR knockout (S-AR-/y) mouse to further evaluate the chronological changes of seminiferous tubules and the molecular mechanisms of SC androgen/AR signals on spermatogenesis. Testes morphology began changing as early as postnatal ...

journal_title：Endocrinology

authors： Wang RS,Yeh S,Chen LM,Lin HY,Zhang C,Ni J,Wu CC,di Sant'Agnese PA,deMesy-Bentley KL,Tzeng CR,Chang C

更新日期：2006-12-01 00:00:00

abstract：:FSH has been shown to stimulate the uptake of calcium in cultured rat Sertoli cells, resulting in an increase in cytosolic calcium concentrations. One possibility which has been put forth is that the FSH receptor per se may act as a calcium channel. This is all the more tantalizing given the proposed structure of this...

journal_title：Endocrinology

authors： Shibata EF,Matsuda JJ,Volk KA,Collison KA,Segaloff DL

更新日期：1992-08-01 00:00:00

abstract：:The FOXO family of forkhead transcription factors stimulates the transcription of target genes involved in many fundamental cell processes, including cell survival, cell cycle progression, DNA repair, and insulin sensitivity. The activity of FOXO proteins is principally regulated by activation of protein kinase B (PKB...

journal_title：Endocrinology

authors： Tsai WC,Bhattacharyya N,Han LY,Hanover JA,Rechler MM

更新日期：2003-12-01 00:00:00

abstract：:Ghrelin, a novel 28 amino acid peptide found in hypothalamus and stomach, was recently identified as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R). We have now found that both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administration of ghrelin in freely feeding rats stimu...

journal_title：Endocrinology

authors： Wren AM,Small CJ,Ward HL,Murphy KG,Dakin CL,Taheri S,Kennedy AR,Roberts GH,Morgan DG,Ghatei MA,Bloom SR

更新日期：2000-11-01 00:00:00

abstract：:Immune activation results in the activation of adrenal steroidogenesis and inhibition of gonadal steroidogenesis. Previous studies indicated that these effects were caused primarily by activation and suppression of the secretion of ACTH and LH, respectively. However, other evidence indicated a direct effect of the imm...

journal_title：Endocrinology

authors： Hales KH,Diemer T,Ginde S,Shankar BK,Roberts M,Bosmann HB,Hales DB

更新日期：2000-11-01 00:00:00

abstract：:We tested the hypothesis that depressed duodenal calcium absorption in the streptozotocin diabetic rat is the consequence of diabetes rather than nephrotoxicity of the diabetogenic agent causing abnormal renal vitamin D metabolism. We treated streptozotocin diabetic rats with insulin and compared their duodenal calciu...

journal_title：Endocrinology

authors： Schneider LE,Nowosielski LM,Schedl HP

更新日期：1977-01-01 00:00:00