Pharmaceuticals in Medicare reform.

abstract：PURPOSE:Rosuvastatin, a hydroxy methylglutaryl coenzyme A reductase inhibitor; telmisartan, an angiotensin receptor blocker; and amlodipine, a calcium channel inhibitor, are commonly prescribed together for the treatment of hypertension nonresponsive to monotherapy and accompanied by dyslipidemia. However, the pharmaco...

journal_title：Clinical therapeutics

authors： Son M,Guk J,Kim Y,Woo Chae D,Heo YA,Soh D,Park K

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:This study was undertaken to examine the dose-response relationship of zafirlukast (5 to 40 mg BID) and to assess the efficacy and tolerability of the 10-mg BID dose in school-aged children with mild to moderate asthma. BACKGROUND:The efficacy and tolerability of zafirlukast, an oral leukotriene-receptor ant...

journal_title：Clinical therapeutics

authors： Pearlman DS,Lampl KL,Dowling PJ Jr,Miller CJ,Bonuccelli CM

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Aspirin is a widely used NSAID that has been extensively studied in numerous conditions. Nonprescription analgesics, such as aspirin, are frequently used for a wide variety of common ailments, including conditions such as dental pain and tension-type headache. OBJECTIVE:We sought to compare the efficacy and...

journal_title：Clinical therapeutics

authors： Gatoulis SC,Voelker M,Fisher M

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Multidrug-resistant bacterial pathogens are becoming a significant problem worldwide. Acinetobacter baumannii and Pseudomonas aeruginosa are problematic multidrug-resistant pathogens. This multicenter study in Vietnam determined the level of resistance to antimicrobial agents used to treat A baumannii and P aer...

journal_title：Clinical therapeutics

authors： Biedenbach DJ,Giao PT,Hung Van P,Su Minh Tuyet N,Thi Thanh Nga T,Phuong DM,Vu Trung N,Badal RE

更新日期：2016-09-01 00:00:00

abstract：:It is generally understood that pain experience and opioid abuse have relied on male-dominated models. However, sex and gender play a role in both pain experience and opioid use disorder. Using the previously validated Texas Tech University Health Sciences Center Sex and Gender Specific Health PubMed Advanced Search T...

journal_title：Clinical therapeutics

authors： Koons AL,Rayl Greenberg M,Cannon RD,Beauchamp GA

更新日期：2018-02-01 00:00:00

abstract：:A prospective, open-label, multicenter, Phase IV study of the efficacy and safety of intravenous (IV) ciprofloxacin (400 mg by 60-minute infusion every 12 hours) in the treatment of lower respiratory tract infections (LRTIs), urinary tract infections (UTIs), and skin/skin structure infections (SSSIs) in hospitalized p...

journal_title：Clinical therapeutics

authors： Pankey GA

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVES:This study was conducted to estimate the prevalence of antipsychotic polypharmacy among fee-for service state Medicaid beneficiaries initiating antipsychotic drug therapy and to investigate psychiatric and demographic predictors of such polypharmacy. METHODS:This was a retrospective cohort study employing M...

journal_title：Clinical therapeutics

authors： Morrato EH,Dodd S,Oderda G,Haxby DG,Allen R,Valuck RJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Recently approved for the treatment of schizophrenia, aripiprazole represents the sixth second-generation antipsychotic (SGA) introduced to the US market. Aripiprazole is considered a partial dopaminergic agonist, acting on both postsynaptic dopamine(2) receptors and presynaptic autoreceptors, in addition to...

journal_title：Clinical therapeutics

authors： DeLeon A,Patel NC,Crismon ML

更新日期：2004-05-01 00:00:00

abstract：:The optimal antibiotic therapy for patients with acute bacterial exacerbations of chronic bronchitis (ABECB) who have failed to respond to previous oral antimicrobial therapy is not known; however, newer macrolide and fluoroquinolone antibiotics may be appropriate. This multicenter, randomized, double-masked, double-d...

journal_title：Clinical therapeutics

authors： Lipsky BA,Unowsky J,Zhang H,Townsend L,Talbot GH

更新日期：1999-06-01 00:00:00

abstract：:A parallel-group, randomized, double-blind, forced-titration, multicenter study was done to compare the efficacy and safety of once-daily nifedipine coat-core (NIF CC) and once-daily nifedipine gastrointestinal therapeutic system (NIF GITS) dosed in the fasting state in patients with mild-to-moderate essential hyperte...

journal_title：Clinical therapeutics

authors： Glasser SP,Ripa SR,Allenby KS,Schwartz LA,Commins BM,Jungerwirth S

更新日期：1995-03-01 00:00:00

abstract：:The pharmacokinetics of cimetidine were studied in three newborn infants with reflux esophagitis or stress ulcer. One infant was given 5 mg/kg intravenously (IV), one was given 10 mg/kg IV, and one was given 10 mg orally. Serum concentrations 30 minutes after administration were 1.2 micrograms/ml, 5 micrograms/ml, and...

journal_title：Clinical therapeutics

authors： Stile IL,Simon R,Hiatt IM,Hegyi T

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The comparative efficacy of endocrine-based therapies (ETs) for hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer (mBC) is not well characterized. This network meta-analysis (NMA) synthesized available evidence on progression-free survival (PFS) wit...

journal_title：Clinical therapeutics

authors： Ayyagari R,Tang D,Patterson-Lomba O,Zhou Z,Xie J,Chandiwana D,Dalal AA,Niravath PA

更新日期：2018-04-01 00:00:00

abstract：:The United States Pharmacopeia (USP) Practitioners' Reporting Network utilized nearly three decades of experience to design and develop a nationwide, anonymous, Internet-accessible service for hospitals to report and benchmark medication errors (also known as "preventable adverse drug events"). As nationwide experient...

journal_title：Clinical therapeutics

authors： Cousins DD

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Active pharmaceutical ingredients that taste bitter and/or irritate the mouth and throat are aversive to children as well as many adults. Effective methods of avoiding unpleasant tastes for adults (eg, encapsulating the medicine in pill, capsule, or tablet form) are problematic because many children cannot o...

journal_title：Clinical therapeutics

authors： Mennella JA,Beauchamp GK

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Rosuvastatin is a new statin indicated to reduce elevated levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides and to increase levels of high-density lipoprotein cholesterol (HDL-C) in patients with primary hypercholesterolemia, mixed dyslipidemia, and homozygous famili...

journal_title：Clinical therapeutics

authors： Cheng JW

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:A combination of clopidogrel and aspirin is the standard treatment for patients with acute coronary syndrome and those undergoing percutaneous coronary intervention. Two novel antiplatelet agents, ticagrelor and prasugrel, have been shown to rapidly and more effectively inhibit the P2Y12 receptor compared with ...

journal_title：Clinical therapeutics

authors： Jeon HS,Kim MJ,Choi HY,Kim YH,Kim EH,Kim AR,Park HJ,Bae KS,Lim HS

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Fever in children is a common and usually benign symptom. It is known that antipyretic treatment is ineffective in the prevention of simple febrile seizures. Caregivers' administration of antipyretic medications to children has been reported, but data concerning the formulations used, actual doses administer...

journal_title：Clinical therapeutics

authors： Bilenko N,Tessler H,Okbe R,Press J,Gorodischer R

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:Coadministration of morphine with oral gabapentin has been shown to increase plasma gabapentin concentrations. This study evaluated whether there was any interaction between gabapentin enacarbil (GEn), which is a prodrug of gabapentin, and morphine in terms of pharmacokinetics, pharmacodynamics, safety, and tol...

journal_title：Clinical therapeutics

authors： Chen C,Upward J,Arumugham T,Stier B,Davy M

更新日期：2015-02-01 00:00:00

abstract：:The effects of long-term treatment with nipradilol, a nitroester-containing beta-blocker, on casual and 24-hour blood pressures were studied in 70 patients with mild-to-moderate essential hypertension. Antihypertensive effects of nipradilol on casual blood pressure were observed in 68% of patients. Nipradilol reduced ...

journal_title：Clinical therapeutics

authors： Haneda T,Ogawa Y,Akaishi T,Takeda H,Tanazawa S,Inoue H,Ohki Y,Kato J,Morimoto H,Kanaya K

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Despite favorable evidence from clinical trials for single-dose palonosetron versus other commercially available 5-HT(3)-receptor antagonists for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV), clinical comparative data are scarce from hospital outpatient settings, where these antiemetic ...

journal_title：Clinical therapeutics

authors： Balu S,Buchner D,Craver C,Gayle J

更新日期：2011-04-01 00:00:00

abstract：:Congestive heart failure (CHF) afflicts more than 4.6 million people in the United States and increases at a rate of 400,000 newly diagnosed patients per year. With more than 1.5 million hospital admissions per year attributed to CHF, it is the number one cause of hospitalization. Hospital length of stay (LOS) is one ...

journal_title：Clinical therapeutics

authors： Simons WR,Haim M,Rizzo J,Zannad F

更新日期：1996-07-01 00:00:00

abstract：:In a previous report of a multicenter study (Kannel et al, 1990), the results of 6 months' treatment with lovastatin in 489 adults with primary hypercholesterolemia were presented. The present report contains the results from the 236 women patients. The intial dose of lovastatin was 20 mg daily and could be increased ...

journal_title：Clinical therapeutics

authors： D'Agostino RB,Kannel WB,Stepanians MN,D'Agostino LC

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Clarithromycin is a semisynthetic macrolide that exhibits broad-spectrum activity against gram-positive, gram-negative, and atypical respiratory tract and skin/skin structure pathogens, Mycobacterium species, and Helicobacter pylori. It is indicated for the treatment of a wide variety of respiratory and derm...

journal_title：Clinical therapeutics

authors： Guay DR,Gustavson LE,Devcich KJ,Zhang J,Cao G,Olson CA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:Pulmonary arterial hypertension (PAH) is a life-threatening disease that typically causes shortness of breath and exercise intolerance. Combination therapy with ambrisentan and tadalafil has proven to be more effective at preventing clinical failure events in patients with PAH than either drug alone. The aim of...

journal_title：Clinical therapeutics

authors： Okour M,Puri A,Chen G,Port K,Berni A,Khindri S,Schneider I,Tenero D

更新日期：2019-06-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) has been available since the mid-1970s. Widespread use of ABPM in research settings has led to an appreciation of its advantages and disadvantages. ABPM is a valuable research tool because of its ability to evaluate the duration and consistency of action with new antihyperte...

journal_title：Clinical therapeutics

authors： Burris JF

更新日期：1993-05-01 00:00:00

abstract：:Self-care with over-the-counter (OTC) medicines has evolved from the "dark ages" of patent medicine manufacture and sale to a modern era of new drug development involving prescription-to-OTC switch. This evolution is largely due to the OTC Review, which placed science at the cornerstone of safety, effectiveness, and l...

journal_title：Clinical therapeutics

authors： Soller RW

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:This Phase 1 pharmacokinetic (PK) comparability study in healthy subjects was performed to compare the PK properties and tolerability of single-dose golimumab 100 mg delivered subcutaneously by an autoinjector device or by a standard needle and syringe that had been used for the subcutaneous (SC) delivery of go...

journal_title：Clinical therapeutics

authors： Xu Z,Marciniak SJ Jr,Frederick B,Kim L,Zhuang Y,Davis HM,Zhou H

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Systemic absorption of topical fluorouracil, although usually low, may vary as a result of the specific skin disease, product formulation, and other factors. OBJECTIVE:The present study was conducted to determine the pharmacokinetic profile and tolerability of a new topical 0.5% fluorouracil cream formulati...

journal_title：Clinical therapeutics

authors： Levy S,Furst K,Chern W

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:Polycystic ovary syndrome (PCOS) is a metabolic and endocrinal disorder affecting a number of women of reproductive age. We aimed to reveal the correlation between the endocannabinoid system and PCOS, which may provide a new therapeutic target for PCOS treatment. METHODS:Serum levels of anandamide and 2-arachi...

journal_title：Clinical therapeutics

authors： Cui N,Feng X,Zhao Z,Zhang J,Xu Y,Wang L,Hao G

更新日期：2017-04-01 00:00:00

abstract：:A double-blind clinical trial was conducted to evaluate the efficacy and safety of flumazenil, a benzodiazepine antagonist, in 146 hospitalized patients, who had had general anesthesia induced by midazolam and a long-acting opioid. Ninety-eight patients received flumazenil and 48 received placebo. Administered postope...

journal_title：Clinical therapeutics

authors：

更新日期：1992-11-01 00:00:00