Species differences in cis-elements of the proalpha1(I) procollagen promoter and their binding proteins.

abstract：:Cranial sutures are important growth sites of the skull. During suture closure, the dura mater is one of the most important sources of various positive and negative regulatory signals. Previous results indicate that TGF-beta2 from dura mater strongly accelerates suture closure, however, its exact regulatory mechanism ...

journal_title：Journal of cellular biochemistry

authors： Lee SW,Choi KY,Cho JY,Jung SH,Song KB,Park EK,Choi JY,Shin HI,Kim SY,Woo KM,Baek JH,Nam SH,Kim YJ,Kim HJ,Ryoo HM

更新日期：2006-07-01 00:00:00

abstract：:Carboxylic acids have various biological activities and play critical roles in cellular metabolic pathways such as the tricarboxylic acid (TCA) cycle. It has been shown that some carboxylic acids induce cell proliferation and production of cytokines or growth factors. However, there have been no reports on effects of ...

journal_title：Journal of cellular biochemistry

authors： Motoki T,Sugiura Y,Matsumoto Y,Tsuji T,Kubota S,Takigawa M,Gohda E

更新日期：2008-07-01 00:00:00

abstract：:Herbal plants are enriched with compounds with a wide range of biological activities. Furanodiene is a sesquiterpene isolated from Rhizoma Curcumae. Growing evidence shows furanodiene exhibits diversified activities of hepatoprotection, anti-inflammation, anti-angiogenesis, and anti-tumor. However, its biological acti...

journal_title：Journal of cellular biochemistry

authors： Zhong ZF,Li YB,Wang SP,Tan W,Chen XP,Chen MW,Wang YT

更新日期：2012-08-01 00:00:00

abstract：:Thrombin is a potent mitogen for human vascular smooth muscle cells (HVSMC) and its enzymatic activity is required for this function. The present study demonstrates that prothrombin is also mitogenic for HVSMC due to the generation of enzymatically active thrombin which occurs upon incubation of prothrombin with the c...

journal_title：Journal of cellular biochemistry

authors： Benzakour O,Kanthou C,Lupu F,Dennehy U,Goodwin C,Scully MF,Kakkar VV,Cooper DN

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is one of the most important immune-mediated disorders of the gastrointestinal tract. Besides, IBD is associated with numerous extraintestinal complications such as venous thromboembolism (VTE), an important risk factor for vascular complications, which results in the increas...

journal_title：Journal of cellular biochemistry

authors： Asadzadeh-Aghdaei H,Mashayekhi K,Koushki K,Azimzadeh P,Rostami-Nejad M,Amani D,Chaleshi V,Haftcheshmeh SM,Sahebkar A,Zali MR

更新日期：2019-09-01 00:00:00

abstract：:Epidermal growth factor (EGF)-receptor is a 170 kDa transmembrane glycoprotein that contains a ligand-binding external domain, and a catalytically active cytoplasmic region. The expression of this receptor as well as a 100 kDa homolog that contains only the external domain is enhanced by the ligand EGF. EGF acts at tr...

journal_title：Journal of cellular biochemistry

authors： Das M,Kesavan P,Khire J

更新日期：1990-09-01 00:00:00

abstract：:Cigarette smoking has been suggested as a risk factor for several periodontal diseases. It has also been found that smokers respond less favorably than non-smokers to periodontal therapy. Previous work in our lab has shown that nicotine inhibits human gingival cell migration. Since myofibroblasts play an important rol...

journal_title：Journal of cellular biochemistry

authors： Fang Y,Svoboda KK

更新日期：2005-08-15 00:00:00

abstract：:In order to better understand the mechanism by which changes in the fatty acid composition of cellular lipids occur in leukemia cell lines induced to differentiate, the activity of the first enzyme of fatty acid biosynthesis, acetyl-CoA carboxylase (EC 6.4.1.2) was measured in HL-60 promyelocytic leukemia cells before...

journal_title：Journal of cellular biochemistry

authors： Fischkoff SA,Papuchis GC,Nickols WA

更新日期：1984-01-01 00:00:00

abstract：:The protective effect of melatonin, 6-hydroxymelatonin and N-acetylserotonin against alpha-naphthylisothiocyanate (ANIT)-induced liver injury was investigated and compared in rats injected once with the hepatotoxicant (75 mg/kg body weight). In rats injected with ANIT alone, liver injury with cholestasis developed wit...

journal_title：Journal of cellular biochemistry

authors： Calvo JR,Reiter RJ,García JJ,Ortiz GG,Tan DX,Karbownik M

更新日期：2001-01-01 00:00:00

abstract：:Ischemia/reperfusion injury is a tissue injury occurring post-reperfusion of tissues with pre-existing ischemia. A good blood supply to tissues aids in the survival of ischemic tissue, however, due to prolonged ischemia the levels of ATP decrease and pH declines leading to acidosis. Reduced ATP leads to an increase in...

journal_title：Journal of cellular biochemistry

authors： Ghaderi S,Alidadiani N,SoleimaniRad J,Heidari HR,Dilaver N,Heim C,Ramsperger-Gleixner M,Baradaran B,Weyand M

更新日期：2018-09-01 00:00:00

abstract：:X-ray atomic structure of recombinant Hell's gate globin I (HGbI) from Methylacidophilum infernorum was calculated from the X-ray diffraction data of two different types of crystals: obtained by classical hanging drop and by LB nanotemplate method under the same crystallization conditions. After the accurate compariso...

journal_title：Journal of cellular biochemistry

authors： Pechkova E,Scudieri D,Belmonte L,Nicolini C

更新日期：2012-07-01 00:00:00

abstract：:Angiogenesis is the central pathological process in hepatocellular carcinoma (HCC), and its progression is affected by tumor cells and the microenvironment. Activated hepatic stellate cells (aHSCs) are the most significant stromal cells involved in HCC. This study was aimed to explore the effects and mechanisms of aHS...

journal_title：Journal of cellular biochemistry

authors： Lin N,Meng L,Lin J,Chen S,Zhang P,Chen Q,Lin Y

更新日期：2020-02-01 00:00:00

abstract：:Serological proteins of neuroblastoma were profiled and analyzed by ProteinChip-SELDI-TOF MS technology with five types of protein chips. By comparing with normal control, a number of protein or polypeptide signals were found significantly and consistently different in their intensities (expression levels) in tumor se...

journal_title：Journal of cellular biochemistry

authors： He QY,Zhu R,Ren Y,Tam PK,Chiu JF

更新日期：2005-05-01 00:00:00

abstract：:Fetal growth restriction (FGR) is a serious pregnancy complication associated with increased perinatal mortality and morbidity. It may lead to neurodevelopmental impairment and adulthood onset disorders. Recently, long noncoding RNAs (lncRNAs) were found to be associated with the pathogenesis of FGR. Here we report th...

journal_title：Journal of cellular biochemistry

authors： Zhang L,Deng X,Shi X,Dong X

更新日期：2019-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short non-coding single-stranded RNAs, which play significant roles in the regulation of a myriad of biological processes. Overwhelmingly increasing high-impact research has also deepened our understanding about the central role of miRNAs in cancer development, metastatic spread, and development...

journal_title：Journal of cellular biochemistry

authors： Wen R,Umeano AC,Essegian DJ,Sabitaliyevich UY,Wang K,Farooqi AA

更新日期：2018-11-01 00:00:00

abstract：:The mitogen regulated protein/proliferin (MRP/PLF) gene is transcribed in primary mouse embryo fibroblasts (MEFs), but the pre-mRNA is not properly converted into a stable cytoplasmic mRNA and instead is rapidly degraded, apparently in the nucleus [Malyankar et al. (1994): Proc Natl Acad Sci USA 91:335-359]. In 3T3 ce...

journal_title：Journal of cellular biochemistry

authors： Malyankar UM,Rittling SR,Denhardt DT

更新日期：1996-02-01 00:00:00

abstract：:The PI3K/AKT/mTOR pathway is one of the most commonly disrupted signaling pathways that plays a role in the development and pathogenicity of multiple cancers. Therefore, the critical proteins of this pathway have been targeted for anticancer therapy. The scientific community has increasingly been realizing the anti-ca...

journal_title：Journal of cellular biochemistry

authors： Rehan M,Bajouh OS

更新日期：2018-10-08 00:00:00

abstract：:The expression of matrix metalloproteinase-13 (MMP-13), involved in bone turnover, is elevated in stretched MC3T3-E1 osteoblast-like cells. Strain-mediated forces impact bone remodeling due in large part to the movement of fluid through the canalicular-lacunar network. The resulting fluid shear stress (FSS) over the s...

journal_title：Journal of cellular biochemistry

authors： Charoonpatrapong-Panyayong K,Shah R,Yang J,Alvarez M,Pavalko FM,Gerard-O'Riley R,Robling AG,Templeton E,Bidwell JP

更新日期：2007-12-01 00:00:00

abstract：:Previous studies have indicated that an increased inflammatory response plays an important role in preeclampsia (PE), and rising levels of interleukin (IL)-22 can trigger inflammation and hyperproliferation, leading to increased production of several pro-inflammatory cytokines such as IL-1, IL-6, and IL-8. We aimed to...

journal_title：Journal of cellular biochemistry

authors： Niu Z,Zhao X,Liu H,Quan J,Lin Y,Li J,Wang J,Liu M,Song W,Chen A,Liu S

更新日期：2018-06-01 00:00:00

abstract：:We observed that treatment of prostate cancer cells for 24 h with magnolol, a phenolic component extracted from the root and stem bark of the oriental herb Magnolia officinalis, induced apoptotic cell death in a dose- and time-dependent manner. A sustained inhibition of the major survival signal, Akt, occurred in magn...

journal_title：Journal of cellular biochemistry

authors： Lee DH,Szczepanski MJ,Lee YJ

更新日期：2009-04-15 00:00:00

abstract：:Accumulating evidence supports the role of miR-122 in fatty liver disease. We investigated miR-122 expression in a steatotic hepatocyte model, the effect of miR-122 over-expression and inhibition in the pathogenesis. Human hepatic cell line L02 was induced with oleic acid to establish the steatotic hepatocyte model. I...

journal_title：Journal of cellular biochemistry

authors： Nie YQ,Cao J,Zhou YJ,Liang X,Du YL,Wan YJ,Li YY

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:This study was designed to explore the protective effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) against ischemia/reperfusion (I/R) injury-induced cardiomyocytes apoptosis. METHODS:The H9c2 cell I/R injury model was induced by simultaneous shortage of nutrients and oxygen. TSG administration...

journal_title：Journal of cellular biochemistry

authors： Sun T,Liu H,Cheng Y,Yan L,Krittanawong C,Li S,Qian W,Su W,Chen X,Hou X,Zhang H

更新日期：2019-03-19 00:00:00

abstract：:Every year about 500,000 people in the United States die as a result of cancer. Among them, 90% exhibit systemic disease with metastasis. Considering this high rate of incidence and mortality, it is critical to understand the mechanisms behind metastasis and identify new targets for therapy. In recent years, two broad...

journal_title：Journal of cellular biochemistry

authors： Tse JC,Kalluri R

更新日期：2007-07-01 00:00:00

abstract：:Renal 11beta-hydroxysteroid dehydrogenase 2 (HSD2) catalyzes the conversion of active glucocorticoids to inert 11beta-keto compounds, thereby preventing the illicit binding of these hormones to mineralocorticoid receptors (MRs) and, thus, conferring aldosterone specificity. Absence or inhibition of HSD2 activity, orig...

journal_title：Journal of cellular biochemistry

authors： Zallocchi ML,Matkovic L,Calvo JC,Damasco MC

更新日期：2004-06-01 00:00:00

abstract：:Membrane type 1 matrix metalloproteinase (MT1-MMP, MMP14) is an efficient extracellular matrix (ECM) degrading enzyme that plays important roles in tissue homeostasis and cell invasion. Like a number of type I membrane proteins, MT1-MMP can be internalized from the cell surface through early and recycling endosomes to...

journal_title：Journal of cellular biochemistry

authors： Hakulinen J,Sankkila L,Sugiyama N,Lehti K,Keski-Oja J

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) has a high morbidity and mortality around the world, yet the effective therapeutic option for HCC is still limited. NPAC, also known as glyoxylate reductase 1 homolog, is a new nuclear protein recently implicated in tumor biology. However, the role of NPAC in HCC remains unclear...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Sun N,Guo W,Wu X,Yang X,Jin H,Zhang Y,Wu X,Zhang F,Hu L,Hu H,Gao Y

更新日期：2018-11-26 00:00:00

abstract：:LipN (Rv2970c) belongs to the Lip family of M. tuberculosis H37Rv and is homologous to the human Hormone Sensitive Lipase. The enzyme demonstrated preference for short carbon chain substrates with optimal activity at 45°C/pH 8.0 and stability between pH 6.0-9.0. The specific activity of the enzyme was 217 U/mg protein...

journal_title：Journal of cellular biochemistry

authors： Jadeja D,Dogra N,Arya S,Singh G,Singh G,Kaur J

更新日期：2016-02-01 00:00:00

abstract：:Lack of guidelines for personalized chemotherapy treatment after surgery has caused gastric cancer (GC) patients' unnecessary exposure to toxicity and the financial burden of chemotherapy treatments. In our study, we aimed to identify potential biomarkers to predict GC patients' susceptibility to platinum-based on Gen...

journal_title：Journal of cellular biochemistry

authors： Pan J,Xiang Z,Dai Q,Wang Z,Liu B,Li C

更新日期：2019-08-01 00:00:00

abstract：:Weightlessness induces bone loss in humans and animal models. We employed the NASA-approved Rotating Wall Vessel bioreactor (RWV) to develop osteoblast-like cell cultures under microgravity and evaluate osteoblast phenotype and cell function. Rat osteoblast-like cell line (ROS.SMER#14) was grown in the RWV at a calcul...

journal_title：Journal of cellular biochemistry

authors： Rucci N,Migliaccio S,Zani BM,Taranta A,Teti A

更新日期：2002-01-01 00:00:00

abstract：:Bladder cancer-associated transcript 1 (BLACAT1) is a novel identified long noncoding RNA (lncRNA) in bladder cancer, and has been suggested to function as an oncogenic lncRNA in several types of human cancer. However, its involvement in the progression of small-cell lung cancer (SCLC) remained unknown. The aim of our...

journal_title：Journal of cellular biochemistry

authors： Chen W,Hang Y,Xu W,Wu J,Chen L,Chen J,Mao Y,Song J,Song J,Wang H

更新日期：2018-09-11 00:00:00