Abstract:
:A 57-year-old man with a history of exposure to silica for 32 years presented with pleural thickening of the lower lobe of the left lung and a chronic right-sided pleural effusion without any radiographic evidence of parenchymal nodules in either lung. Light microscopic examination of a left visceral pleural biopsy specimen revealed markedly thickened pleura with fibrosis and macrophages containing birefringent silica and silicates. Occasional rounded intrapleural silicotic nodules were present. The underlying lung tissue did not show fibrosis or silicotic nodules. An energy-dispersive x-ray analysis confirmed the presence of silica. In the absence of lung involvement, this case represents a very unusual pathologic reaction caused by silica and silicates and adds to the clinical differential diagnosis of chronic pleuritis and malignant mesothelioma.
journal_name
Chestjournal_title
Chestauthors
Zeren EH,Colby TV,Roggli VLdoi
10.1378/chest.112.5.1436subject
Has Abstractpub_date
1997-11-05 00:00:00pages
1436-8issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(15)47333-7journal_volume
112pub_type
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