Contributions of GABAA receptors and GABAC receptors to acetylcholine release and directional selectivity in the rabbit retina.

Abstract:

:GABA is a major inhibitory neurotransmitter in the mammalian retina and it acts at many different sites via a variety of postsynaptic receptors. These include GABAA receptors and bicuculline-resistant GABAC receptors. The release of acetylcholine (ACh) is inhibited by GABA and strongly potentiated by GABA antagonists. In addition, GABA appears to mediate the null inhibition which is responsible for the mechanism of directional selectivity in certain ganglion cells. We have used these two well-known examples of GABA inhibition to compare three GABA antagonists and assess the contributions of GABAA and GABAC receptors. All three GABA antagonists stimulated ACh release by as much as ten-fold. By this measure, the ED50s for SR-95531, bicuculline, and picrotoxin were 0.8, 7.0, and 14 microM, respectively. Muscimol, a potent GABAA agonist, blocked the effects of SR-95531 and bicuculline, but not picrotoxin. This indicates that SR-95531 and bicuculline are competitive antagonists at the GABAA receptor, while picrotoxin blocks GABAA responses by acting at a different, nonreceptor site such as the chloride channel. In the presence of a saturating dose of SR-95531 to completely block GABAA receptors, picrotoxin caused a further increase in the release of ACh. This indicates that picrotoxin potentiates ACh release by a mechanism in addition to the block of GABAA responses, possibly by also blocking GABAC receptors, which have been associated with bipolar cells. All three GABA antagonists abolished directionally selective responses from ON/OFF directional-selective (DS) ganglion cells. In this system, the ED50S for SR-95531, bicuculline, and picrotoxin were 0.7 microM, 8 microM, and 94.6 microM, respectively. The results with SR-95531 and bicuculline indicate that GABAA receptors mediate the inhibition responsible for directional selectivity. The addition of picrotoxin to a high dose of SR-95531 caused no further increase in firing rate. The comparatively high dose required for picrotoxin also suggests that GABAC receptors do not contribute to directional selectivity. This in turn suggests that feedforward GABAA inhibition, as opposed to feedback at bipolar terminals, is responsible for the null inhibition underlying directional selectivity.

journal_name

Vis Neurosci

journal_title

Visual neuroscience

authors

Massey SC,Linn DM,Kittila CA,Mirza W

doi

10.1017/s0952523800011652

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

939-48

issue

5

eissn

0952-5238

issn

1469-8714

pii

S0952523800011652

journal_volume

14

pub_type

杂志文章
  • Radial motion bias in macaque frontal eye field.

    abstract::The visual responsiveness and spatial tuning of frontal eye field (FEF) neurons were determined using a delayed memory saccade task. Neurons with visual responses were then tested for direction selectivity using moving random dot patterns centered in the visual receptive field. The preferred axis of motion showed a si...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523806231055

    authors: Xiao Q,Barborica A,Ferrera VP

    更新日期:2006-01-01 00:00:00

  • Characterization of a novel large-field cone bipolar cell type in the primate retina: evidence for selective cone connections.

    abstract::Parallel processing of visual information begins at the first synapse in the retina between the photoreceptors and bipolar cells. Ten bipolar cell types have been previously described in the primate retina: one rod and nine cone bipolar types. In this paper, we describe an 11th type of bipolar cell identified in Golgi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523810000374

    authors: Joo HR,Peterson BB,Haun TJ,Dacey DM

    更新日期:2011-01-01 00:00:00

  • Neuropharmacological analysis of the role of indoleamine-accumulating amacrine cells in the rabbit retina.

    abstract::In order to elucidate the role of putative indoleaminergic amacrine cells in visual processing, we have employed pharmacological agents specific for the two classes of serotonin receptor, 5-HT2 and 5-HT1, which have been identified in both the retina and brain. Perfusion of the rabbit retina with 5-HT2 selective antag...

    journal_title:Visual neuroscience

    pub_type: 杂志文章,评审

    doi:10.1017/s0952523800001930

    authors: Brunken WJ,Daw NW

    更新日期:1988-01-01 00:00:00

  • Depletion of retinal dopamine does not affect the ERG b-wave increment threshold function in goldfish in vivo.

    abstract::Increment threshold functions of the electroretinogram (ERG) b-wave were obtained from goldfish using an in vivo preparation to study intraretinal mechanisms underlying the increase in perceived brightness induced by depletion of retinal dopamine by 6-hydroxydopamine (6-OHDA). Goldfish received unilateral intraocular ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252380000300x

    authors: Lin ZS,Yazulla S

    更新日期:1994-07-01 00:00:00

  • Whole-cell recording of light-evoked photoreceptor responses in a slice preparation of the cuttlefish retina.

    abstract::A new tissue slice preparation of the cuttlefish eye is described that permits patch-clamp recordings to be acquired from intact photoreceptors during stimulation of the retina with controlled light flashes. Whole-cell recordings using this preparation, from the retinas of very young Sepia officinalis demonstrated tha...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523805223106

    authors: Chrachri A,Nelson L,Williamson R

    更新日期:2005-05-01 00:00:00

  • The role of spontaneous retinal activity before eye opening in the maturation of form and function in the retinogeniculate pathway of the ferret.

    abstract::During early mammalian development, inputs from the two retinas intermix within the lateral geniculate nucleus (LGN), then segregate during the first postnatal week into layers that receive input from a single retina. Functionally, the LGN also changes markedly during the first postnatal month; early geniculate respon...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523899163107

    authors: Cook PM,Prusky G,Ramoa AS

    更新日期:1999-05-01 00:00:00

  • Psychophysical analysis of contrast processing segregated into magnocellular and parvocellular systems in asymptomatic carriers of 11778 Leber's hereditary optic neuropathy.

    abstract::We examined achromatic contrast discrimination in asymptomatic carriers of 11778 Leber's hereditary optic neuropathy (LHON 18 controls) and 18 age-match were also tested. To evaluate magnocellular (MC) and Parvocellular (PC) contrast discrimination, we used a version of Pokorny and Smith's (1997) pulsed/steady-pedesta...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080462

    authors: Gualtieri M,Bandeira M,Hamer RD,Costa MF,Oliveira AG,Moura AL,Sadun F,De Negri AM,Berezovsky A,Salomão SR,Carelli V,Sadun AA,Ventura DF

    更新日期:2008-05-01 00:00:00

  • Number and topography of cones, rods and optic nerve axons in New and Old World primates.

    abstract::To better understand the evolution of spatial and color vision, the number and spatial distributions of cones, rods, and optic nerve axon numbers were assessed in seven New World primates (Cebus apella, Saimiri ustius, Saguinus midas niger, Alouatta caraya, Aotus azarae, Calllithrix jacchus, and Callicebus moloch). Th...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080371

    authors: Finlay BL,Franco EC,Yamada ES,Crowley JC,Parsons M,Muniz JA,Silveira LC

    更新日期:2008-05-01 00:00:00

  • Intact "biological motion" and "structure from motion" perception in a patient with impaired motion mechanisms: a case study.

    abstract::A series of psychophysical tests examining early and later aspects of image-motion processing were conducted in a patient with bilateral lesions involving the posterior visual pathways, affecting the lateral parietal-temporal-occipital cortex and the underlying white matter (as shown by magnetic resonance imaging stud...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800000444

    authors: Vaina LM,Lemay M,Bienfang DC,Choi AY,Nakayama K

    更新日期:1990-10-01 00:00:00

  • Topography of long- and middle-wavelength sensitive cone opsin gene expression in human and Old World monkey retina.

    abstract::The topographical distributions of the relative ratio of long- (L) and middle- (M) wavelength sensitive cone opsin messenger RNA (mRNA) in human and baboon retinas were mapped using real-time polymerase chain reaction. The L:M mRNA ratio increased in a central-to-peripheral gradient in both species, being quite pronou...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S095252380623325X

    authors: Neitz M,Balding SD,McMahon C,Sjoberg SA,Neitz J

    更新日期:2006-05-01 00:00:00

  • Screening of gap junction antagonists on dye coupling in the rabbit retina.

    abstract::Many cell types in the retina are coupled via gap junctions and so there is a pressing need for a potent and reversible gap junction antagonist. We screened a series of potential gap junction antagonists by evaluating their effects on dye coupling in the network of A-type horizontal cells. We evaluated the following c...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523807070472

    authors: Pan F,Mills SL,Massey SC

    更新日期:2007-07-01 00:00:00

  • Variability in mitochondria of zebrafish photoreceptor ellipsoids.

    abstract::Ultrastructural examination of photoreceptor inner segment ellipsoids in larval (4, 8, and 15 days postfertilization; dpf) and adult zebrafish identified morphologically different types of mitochondria. All photoreceptors had mitochondria of different sizes (large and small). At 4 dpf, rods had small, moderately stain...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S095252381300059X

    authors: Tarboush R,Novales Flamarique I,Chapman GB,Connaughton VP

    更新日期:2014-01-01 00:00:00

  • Divergent feedback connections from areas V4 and TEO in the macaque.

    abstract::Extrastriate areas TEO and V4 have been associated with form and color vision. Area V4 has also been suggested to participate in processes concerned with attention, stimulus salience, and perceptual learning. In a continuing effort to elucidate the connectional interactions and microcircuitry of these areas, we descri...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800002480

    authors: Rockland KS,Saleem KS,Tanaka K

    更新日期:1994-05-01 00:00:00

  • Contrast adaptation in retinal and cortical evoked potentials: no adaptation to low spatial frequencies.

    abstract::Contrast adaptation occurs in both the retina and the cortex. Defining its spatial dependence is crucial for understanding its potential roles. We thus asked to what degree contrast adaptation depends on spatial frequency, including cross-adaptation. Measuring the pattern electroretinogram (PERG) and the visual evoked...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523802195095

    authors: Heinrich TS,Bach M

    更新日期:2002-09-01 00:00:00

  • Long-range interactions modulate the contrast gain in the lateral geniculate nucleus of cats.

    abstract::In previous work, we have shown that sudden image displacements well outside the classical receptive field modulate the visual sensitivity of LGN relay cells. Here we report the effect of image displacements on the response versus contrast function. The stimuli consisted of a central spot of optimal size and polarity ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523899165143

    authors: Felisberti F,Derrington AM

    更新日期:1999-09-01 00:00:00

  • Effects of ON channel blockade with 2-amino-4-phosphonobutyrate (APB) on brightness and contrast perception in monkeys.

    abstract::Four experiments were performed to assess the effects of ON channel blockade with the glutamate analog 2-amino-4-phosphonobutyrate (APB) on brightness and contrast perception in monkeys. In Experiment 1, we demonstrate that stimuli brighter than background (incremental stimuli) appear less bright following ON channel ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252380001107x

    authors: Dolan RP,Schiller PH

    更新日期:1994-01-01 00:00:00

  • Space-time spectra of complex cell filters in the macaque monkey: a comparison of results obtained with pseudowhite noise and grating stimuli.

    abstract::White noise stimuli were used to estimate second-order kernels for complex cells in cortical area V1 of the macaque monkey, and drifting grating stimuli were presented to the sample of neurons to obtain orientation and spatial-frequency tuning curves. Using these data, we quantified how well second-order kernels predi...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800003102

    authors: Gaska JP,Jacobson LD,Chen HW,Pollen DA

    更新日期:1994-07-01 00:00:00

  • Neurotransmitters, receptors, and neuropeptides in the accessory optic system: an immunohistochemical survey in the pigeon (Columba livia).

    abstract::Immunohistochemical techniques were used to survey the distribution of several conventional transmitters, receptors, and neuropeptides in the pigeon nucleus of the basal optic root (nBOR), a component of the accessory optic system. Amongst the conventional neurotransmitters/modulators, the most intense labeling of fib...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800005964

    authors: Britto LR,Hamassaki DE,Keyser KT,Karten HJ

    更新日期:1989-11-01 00:00:00

  • Saccade target selection in macaque during feature and conjunction visual search.

    abstract::To gain insight into how vision guides eye movements, monkeys were trained to make a single saccade to a specified target stimulus during feature and conjunction search with stimuli discriminated by color and shape. Monkeys performed both tasks at levels well above chance. The latencies of saccades to the target in co...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523899161042

    authors: Bichot NP,Schall JD

    更新日期:1999-01-01 00:00:00

  • Sensitivity transformation for vertebrate vision.

    abstract::The visual response to a flash given in the dark is known to saturate according to the Michaelis-Menten relationship. Nevertheless, the incremental response from increasing levels of mean luminance tends to follow a Weber-Fechner relationship well into the saturation range determined from the Michaelis-Menten results....

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800006593

    authors: Chappell RL,Naka K

    更新日期:1991-04-01 00:00:00

  • Rescue of excitation by inositol following Li(+)-induced block in Limulus ventral photoreceptors.

    abstract::The phosphoinositide (PI) intracellular signaling pathway, which triggers Ca2+ release from intracellular stores, appears to be a central feature of phototransduction in most invertebrate species studied. Procedures designed to inhibit PI-pathway reactions cause suppression of excitation to dim lights. However, in Lim...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523898151076

    authors: Johnson EC,Gray-Keller MP,O'Day PM

    更新日期:1998-01-01 00:00:00

  • Visual callosal projections in the adult ferret.

    abstract::The laminar and tangential organization of visual callosal projections of areas 17 and 18 were investigated in the adult ferret, using histochemical methods to visualize axonally transported horseradish peroxidase (HRP). Normal adult ferrets were given injections of HRP throughout one visual cortex or had gelfoam soak...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800006398

    authors: Grigonis AM,Rayos del Sol-Padua RB,Murphy EH

    更新日期:1992-07-01 00:00:00

  • Alpha ganglion cells of the rabbit retina lose antagonistic surround responses under dark adaptation.

    abstract::Alpha ganglion cells from the midperiphery of the rabbit retina were recorded intracellularly under visual control, in a superfused everted eyecup, and labeled with HRP. Their physiology and large somata with broad dendritic arbors identified them as uniform populations of ON- and OFF-center alpha ganglion cells, whic...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800011512

    authors: Muller JF,Dacheux RF

    更新日期:1997-03-01 00:00:00

  • Is the input to a GABAergic synapse the sole asymmetry in turtle's retinal directional selectivity?

    abstract::We examined the effects of picrotoxin and pentylenetetrazol (PTZ) on the responses to motions of ON-OFF directionally selective (DS) ganglion cells of the turtle's retina. These drugs are antagonists of the inhibitory neurotransmitter GABA. For continuous motions, picrotoxin markedly reduced the overall directionality...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800008105

    authors: Smith RD,Grzywacz NM,Borg-Graham LJ

    更新日期:1996-05-01 00:00:00

  • Simulation of an anatomically defined local circuit: the cone-horizontal cell network in cat retina.

    abstract::The outer plexiform layer of the retina contains a neural circuit in which cone synaptic terminals are electrically coupled and release glutamate onto wide-field and narrow-field horizontal cells. These are also electrically coupled and feed back through a GABAergic synapse to cones. In cat this circuit's structure is...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s0952523800008440

    authors: Smith RG

    更新日期:1995-05-01 00:00:00

  • Minimum-variance cone-excitation ratios and the limits of relational color constancy.

    abstract::Relational color constancy refers to the constancy of the perceived relations between the colors of surfaces of a scene under changes in the spectral composition of the illuminant. Spatial ratios of cone excitations provide a natural physical basis for this constancy, as, on average, they are almost invariant under il...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252380421327x

    authors: Nascimento SM,de Almeida VM,Fiadeiro PT,Foster DH

    更新日期:2004-05-01 00:00:00

  • Robust directional computation in on-off directionally selective ganglion cells of rabbit retina.

    abstract::The spatial and temporal interactions in the receptive fields of On-Off directionally selective (DS) ganglion cells endow them with directional selectivity. Using a variety of stimuli, such as sinusoidal gratings, we show that these interactions make directional selectivity of the DS ganglion cell robust with respect ...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523807070666

    authors: Grzywacz NM,Amthor FR

    更新日期:2007-07-01 00:00:00

  • Wide-field cone bipolar cells and the blue-ON pathway to color-coded ganglion cells in rabbit retina.

    abstract::Wide-field cone bipolar cells with sparse dendritic branching and proposed connectivity to blue cones were first identified in rabbit and cat. In rabbit, these were subdivided into type a (wa) and type b (wb), with axonal branching in sublamina a, and sublamina b, respectively, of the inner plexiform layer (IPL). Rece...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523808080061

    authors: Famiglietti EV

    更新日期:2008-01-01 00:00:00

  • Projection status of calbindin- and parvalbumin-immunoreactive neurons in the superficial layers of the rat's superior colliculus.

    abstract::Immunocytochemistry and retrograde labeling were used to define the thalamic projections of calbindin- and parvalbumin-containing cells in superficial layers of the rat's superior colliculus (SC). Quantitative analysis revealed that 90.8 +/- 2.2% (mean +/- standard deviation) of the calbindin-immunoreactive neurons in...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/s095252380001141x

    authors: Lane RD,Allan DM,Bennett-Clarke CA,Howell DL,Rhoades RW

    更新日期:1997-03-01 00:00:00

  • Inhibitory components of retinal bipolar cell receptive fields are differentially modulated by dopamine D1 receptors.

    abstract::During adaptation to an increase in environmental luminance, retinal signaling adjustments are mediated by the neuromodulator dopamine. Retinal dopamine is released with light and can affect center-surround receptive fields, the coupling state between neurons, and inhibitory pathways through inhibitory receptors and n...

    journal_title:Visual neuroscience

    pub_type: 杂志文章

    doi:10.1017/S0952523819000129

    authors: Mazade RE,Eggers ED

    更新日期:2020-02-12 00:00:00