Effect of intermittent cyclical disodium etidronate therapy on bone mineral density in men with vertebral fractures.

Abstract:

OBJECTIVES:to investigate the effects of oral intermittent cyclical etidronate therapy on bone mineral density (BMD) in men with idiopathic vertebral osteoporosis. DESIGN:consecutive case series. SETTING:regional specialist clinic for metabolic bone disease. SUBJECTS:42 men aged 35-81 (median 60.5) with established vertebral crush fractures and back pain, in whom secondary causes of osteoporosis had been excluded. INTERVENTION:repeated cycles of treatment with oral disodium etidronate 400 mg daily for 14 days followed by oral calcium 500 mg as citrate daily for 76 days. OUTCOME MEASURES:BMD measurement of the lumbar spine and femoral neck by dual energy x-ray absorptiometry at 6-12-month intervals; bone biochemistry (serum calcium, phosphate, alkaline phosphatase and urine calcium/creatinine and hydroxyproline/creatinine ratios) at 6-month intervals. RESULTS:all 42 men have been treated for more than 18 months, and 35 of them for more than 24 months. Median follow-up for the group as a whole is 31 months (range 18-45). The treatment was well tolerated. BMD at the lumbar spine increased by a mean of 0.024 g/cm2 per year of follow-up (95% confidence interval 0.017-0.032 g/cm2). This is equivalent to an average annual rate of change of 3.2% of baseline values. There was a small, non-significant rise in mean BMD at the hip equivalent to 0.7% of baseline values per year. Serum alkaline phosphatase tended to fall in the first 6 months of treatment, returning to baseline values at 2 years. Serum calcium and phosphate were unchanged and no decrease in urinary calcium/creatinine ratio or hydroxyproline/creatinine ratio was seen. CONCLUSIONS:intermittent cyclical etidronate therapy increased lumbar spine BMD over a 2-year period in an unselected group of men with osteoporotic vertebral fractures. This treatment warrants further evaluation in a randomized controlled trial.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Anderson FH,Francis RM,Bishop JC,Rawlings DJ

doi

10.1093/ageing/26.5.359

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

359-65

issue

5

eissn

0002-0729

issn

1468-2834

journal_volume

26

pub_type

杂志文章
  • Increasing delirium skills at the front door: results from a repeated survey on delirium knowledge and attitudes.

    abstract:BACKGROUND:delirium is under-recognised in comparison to other common and serious acute disorders. A 2006 survey of UK junior doctors (not undertaking specialist training) identified poor knowledge of the diagnostic criteria and treatment of delirium. We hypothesised that increased prominence accorded to delirium in th...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw066

    authors: Jenkin RP,Al-Attar A,Richardson S,Myint PK,MacLullich AM,Davis DH

    更新日期:2016-07-01 00:00:00

  • Life-style factors associated with winter serum 25-hydroxyvitamin D levels in elderly adults.

    abstract::A cross-sectional survey of community-dwelling elderly volunteers (104 women, 87 men, mean age 70 years) was carried out in winter to determine whether cardiovascular and other potentially modifiable lifestyle factors were associated with serum levels of 25-hydroxyvitamin D during this period. Mean winter levels of se...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/24.4.271

    authors: Scragg R,Khaw KT,Murphy S

    更新日期:1995-07-01 00:00:00

  • Glaucoma therapy may take your breath away.

    abstract::Chronic simple glaucoma is a common disease in old age and lowering intraocular pressure is the treatment strategy. Although this can be achieved surgically, medical treatment with eye drops is more often prescribed. Beta-antagonists are the class of drug most often chosen, although other medical therapies are availab...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/26.2.63

    authors: Diggory P,Franks WA

    更新日期:1997-03-01 00:00:00

  • Human immunodeficiency virus (HIV) in older people.

    abstract::The number of older people living with human immunodeficiency virus (HIV) in the UK is rising. Older people are at risk of acquiring HIV infection for a multitude of reasons. This, combined with effective HIV treatment which has significantly prolonged life expectancy, means that health care professionals working in t...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/afq009

    authors: Pratt G,Gascoyne K,Cunningham K,Tunbridge A

    更新日期:2010-05-01 00:00:00

  • Proximity to death is associated with frequency of GP contacts in the oldest old: the Leiden 85-plus study.

    abstract:BACKGROUND:the relationship between proximity to death and the amount of care provided by general practitioners (GPs) is largely unknown. OBJECTIVE:to examine the influence of the proximity to death on the frequency and length of GP contacts in the oldest old. STUDY DESIGN:this population-based follow-up study includ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs062

    authors: Blom JW,Lemmens SP,Assendelft WJ,Eekhof JA,Gussekloo J

    更新日期:2012-11-01 00:00:00

  • Factors associated with self- and informant ratings of quality of life, well-being and life satisfaction in people with mild-to-moderate dementia: results from the Improving the experience of Dementia and Enhancing Active Life programme.

    abstract:BACKGROUND:a large number of studies have explored factors related to self- and informant ratings of quality of life in people with dementia, but many studies have had relatively small sample sizes and mainly focused on health conditions and dementia symptoms. The aim of this study is to compare self- and informant-rat...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afz177

    authors: Wu YT,Nelis SM,Quinn C,Martyr A,Jones IR,Victor CR,Knapp M,Henderson C,Hindle JV,Jones RW,Kopelman MD,Morris RG,Pickett JA,Rusted JM,Thom JM,Litherland R,Matthews FE,Clare L,IDEAL Programme team.

    更新日期:2020-04-27 00:00:00

  • Personal growth and development in old age-a clinician's perspective.

    abstract::This invited article is drawn from the content of the Marjory Warren Lecture given by John Gladman at the British Geriatrics Society Spring Meeting in 2018, entitled 'The Meaning of Life Expectancy'. ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afy130

    authors: Gladman JRF

    更新日期:2019-01-01 00:00:00

  • Prospective trial of a new diagnostic criterion for severe wasting malnutrition in the elderly.

    abstract::From an international comparison of arm anthropometric reference norms for the elderly a new diagnostic criterion for severe wasting malnutrition was derived: corrected arm muscle area at or below 16.0 cm2 for men or 16.9 cm2 for women. Of 201 consecutive hospital admissions aged 65 years and over, 10 subjects were ma...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/14.3.149

    authors: Friedman PJ,Campbell AJ,Caradoc-Davies TH

    更新日期:1985-05-01 00:00:00

  • A double-blind comparison of quinine sulphate and placebo in muscle cramps.

    abstract::Muscle cramps are painful and common in elderly patients but have largely escaped medical investigation. Quinine sulphate is usually the sole drug prescribed, even though firm evidence for its efficacy is not available. The results of the present double-blind cross-over study show that quinine was significantly superi...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/12.2.155

    authors: Jones K,Castleden CM

    更新日期:1983-05-01 00:00:00

  • Pain and delirium in people with dementia in the acute general hospital setting.

    abstract:Background:Pain and delirium are common in people with dementia admitted to hospitals. These are often under-diagnosed and under-treated. Pain is implicated as a cause of delirium but this association has not been investigated in this setting. Objective:To investigate the relationship between pain and delirium in peop...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ageing/afy112

    authors: Feast AR,White N,Lord K,Kupeli N,Vickerstaff V,Sampson EL

    更新日期:2018-11-01 00:00:00

  • A pharmacy discharge plan for hospitalized elderly patients--a randomized controlled trial.

    abstract:OBJECTIVES:to investigate the effectiveness of a pharmacy discharge plan in elderly hospitalized patients. DESIGN:randomized controlled trial. SUBJECTS AND SETTINGS:we randomized patients aged 75 years and older on four or more medicines who had been discharged from three acute general and one long-stay hospital to a...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/30.1.33

    authors: Nazareth I,Burton A,Shulman S,Smith P,Haines A,Timberal H

    更新日期:2001-01-01 00:00:00

  • Persistent pain is a risk factor for frailty: a systematic review and meta-analysis from prospective longitudinal studies.

    abstract:Background:pain is prevalent in frail older adults; however, the association of pain and frailty has not been evaluated yet by a systematic assessment of prospective longitudinal studies. Objective:we aimed to assess the association of persistent pain as a risk factor for frailty incidence, using data from longitudina...

    journal_title:Age and ageing

    pub_type: 杂志文章,meta分析

    doi:10.1093/ageing/afy104

    authors: Saraiva MD,Suzuki GS,Lin SM,de Andrade DC,Jacob-Filho W,Suemoto CK

    更新日期:2018-11-01 00:00:00

  • Peritonitis in geriatric inpatients.

    abstract::Of 212 cases of peritonitis found in a retrospective study of geriatric inpatients, the most common causes were mesenteric infarction, malignancy, intestinal obstruction, perforated peptic ulcer, cholecystitis, diverticulitis and perforation of the urinary bladder. The diagnostic accuracy was 47%. Abdominal pain had b...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/20.2.90

    authors: Wroblewski M,Mikulowski P

    更新日期:1991-03-01 00:00:00

  • Associated factors with antipsychotic use in assisted living facilities: a cross-sectional study of 4367 residents.

    abstract:BACKGROUND:antipsychotics are widely used in assisted living (AL facilities). Even more, the prescription of these drugs is gradually increasing since the availability of second-generation atypical antipsychotics. More knowledge is needed on prescription reasons to understand this increasing prevalence. METHODS:cross-...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afr032

    authors: Larrayadieu A,Abellan van Kan G,Piau A,Soto Martin M,Nourhashemi F,Rolland Y,Vellas B

    更新日期:2011-05-01 00:00:00

  • How empowering is hospital care for older people with advanced disease? Barriers and facilitators from a cross-national ethnography in England, Ireland and the USA.

    abstract:Background:patient empowerment, through which patients become self-determining agents with some control over their health and healthcare, is a common theme across health policies globally. Most care for older people is in the acute setting, but there is little evidence to inform the delivery of empowering hospital care...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ageing/afw193

    authors: Selman LE,Daveson BA,Smith M,Johnston B,Ryan K,Morrison RS,Pannell C,McQuillan R,de Wolf-Linder S,Pantilat SZ,Klass L,Meier D,Normand C,Higginson IJ

    更新日期:2017-03-01 00:00:00

  • Severity of age-related hearing loss is associated with impaired activities of daily living.

    abstract:BACKGROUND:age-related hearing loss is a common chronic condition; hence, it is important to understand its influence on the functional status of older adults. We assessed the association between hearing impairment with activity limitations as assessed by the activities of daily living (ADL) scale. METHODS:a total of ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afr155

    authors: Gopinath B,Schneider J,McMahon CM,Teber E,Leeder SR,Mitchell P

    更新日期:2012-03-01 00:00:00

  • Observer variation in the clinical assessment of stroke.

    abstract::Clinical assessments have to be used in epidemiological studies in the absence of more objective means of establishing diagnosis or recording events in the natural history of disease. This requires the standardization of definition, technique and interpretation as a means of reducing observer variability in clinical e...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/5.4.233

    authors: Garraway WM,Akhtar AJ,Gore SM,Prescott RJ,Smith RG

    更新日期:1976-11-01 00:00:00

  • Proximal femoral fractures in the elderly: does operative delay for medical reasons affect short-term outcome?

    abstract::Forty patients over 65 years of age with fractures of the proximal femur, whose operation was delayed more than 24 hours after admission for medical reasons, were studied. Length of post-operative stay on the orthopaedic wards, mobility after one month and need for continuing supervision by the geriatric services, aft...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/20.1.41

    authors: Harries DJ,Eastwood H

    更新日期:1991-01-01 00:00:00

  • The value of specialist clinical assessment of older people prior to entry to care homes.

    abstract:OBJECTIVE:to ascertain the value of employing a specialist clinician's contribution to the assessment of older people prior to care home entry. DESIGN:randomised controlled trial. METHOD:256 older people at risk of care home entry were randomly allocated to either a control group, who received the usual care manageme...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/afh007

    authors: Challis D,Clarkson P,Williamson J,Hughes J,Venables D,Burns A,Weinberg A

    更新日期:2004-01-01 00:00:00

  • Evidence of cellular zinc depletion in hospitalized but not in healthy elderly subjects.

    abstract::Cellular immune function declines with age and is implicated in the increased incidence of cancer, and morbidity and mortality associated with infections in elderly people. Elderly people are at risk of nutritional depletion, including of zinc, and zinc is known to influence immunity. The present study assessed zinc s...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/20.5.345

    authors: Goode HF,Penn ND,Kelleher J,Walker BE

    更新日期:1991-09-01 00:00:00

  • The levodopa test in Parkinson's disease.

    abstract::The clinical diagnosis of Parkinson's disease may be difficult. In elderly patients there may be other causes of the triad of rigidity, bradykinesia and tremor. This study was designed to assess whether a single levodopa challenge could predict dopa responsiveness in patients with Parkinson's disease. Twenty-two of 27...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/24.3.210

    authors: D'Costa DF,Sheehan LJ,Phillips PA,Moore-Smith B

    更新日期:1995-05-01 00:00:00

  • Person-centred dementia services are feasible, but can they be sustained?

    abstract:BACKGROUND:we evaluated a specialist community-based dementia service to establish whether high quality care was being delivered and the conditions for doing so. The service was in an urban part of Rushcliffe Primary Care Trust, Nottinghamshire, United Kingdom. The service comprised an assessment team of an occupationa...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afl161

    authors: Gladman JR,Jones RG,Radford K,Walker E,Rothera I

    更新日期:2007-03-01 00:00:00

  • Older age is associated with less cancer treatment: a longitudinal study of English cancer patients.

    abstract:Background:making informed decisions about cancer care provision for older cancer patients can be challenging and complex. Evidence suggests cancer care varies by age, however the relationship between age and care experiences from diagnosis to death for cancer patients within the UK has not previously been examined in ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afy094

    authors: Craigs CL,Bennett MI,Hurlow A,West RM,Ziegler LE

    更新日期:2018-11-01 00:00:00

  • Age-associated change in pain threshold measured by transcutaneous neuronal electrical stimulation.

    abstract::The measurement of cutaneous pain threshold using the Neuromod Selectra Model 7750 Transcutaneous Neuronal Electrical Stimulator is described. Pain threshold, measured in 520 healthy volunteers aged 5-105 years, increased with age. Consistent values were obtained in 22 healthy volunteers on three successive days. Pain...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/18.4.241

    authors: Tucker MA,Andrew MF,Ogle SJ,Davison JG

    更新日期:1989-07-01 00:00:00

  • A modelling-based economic evaluation of primary-care-based fall-risk screening followed by fall-prevention intervention: a cohort-based Markov model stratified by older age groups.

    abstract:BACKGROUND:fall-risk assessment with fall-prevention intervention referral for at-risk groups to avoid falls could be cost-effective from a care-payer perspective. AIMS:to model the cost-effectiveness of a fall-risk assessment (QTUG compared to TUG) with referral to one of four fall-prevention interventions (Otago, Fa...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afz125

    authors: Franklin M,Hunter RM

    更新日期:2019-12-01 00:00:00

  • Falls by elderly people at home: prevalence and associated factors.

    abstract::Of 1042 individuals aged 65 years and over who were successfully interviewed in a community survey of health and physical activity, 35% (n = 356) reported one or more falls in the preceding year. Although the overall ratio of female fallers to male fallers was 2.7:1, this ratio approached unity with advancing age. Mob...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/17.6.365

    authors: Blake AJ,Morgan K,Bendall MJ,Dallosso H,Ebrahim SB,Arie TH,Fentem PH,Bassey EJ

    更新日期:1988-11-01 00:00:00

  • Bilateral facial palsy in an older person.

    abstract::Lyme disease is an infectious disease caused by the Borrelia burgdorferi spirochetes and other related species that are transmitted through an infected tick bite. We report the case of an older patient presenting with bilateral facial palsy due to Lyme disease. Multiple non-specific clinical signs preceded facial pals...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa082

    authors: Méreaux JL,Hébant B,Magne N,Quesney G,Lefaucheur R

    更新日期:2020-08-24 00:00:00

  • Occupational therapy compared with social work assessment for older people. An economic evaluation alongside the CAMELOT randomised controlled trial.

    abstract:OBJECTIVES:To compare costs and outcome of occupational therapy-led assessment with social worker-led assessment of older people, in terms of their independence and quality of life. DESIGN:Cost-effectiveness analysis alongside a randomised controlled trial. The analysis took viewpoints of health services and patients....

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/afh232

    authors: Flood C,Mugford M,Stewart S,Harvey I,Poland F,Lloyd-Smith W

    更新日期:2005-01-01 00:00:00

  • A re-validation of the Rivermead ADL scale for elderly patients with stroke.

    abstract::The Rivermead ADL scale was developed for assessing activities of daily living in stroke patients but was not validated for elderly subjects. This study was designed to validate the scale for patients aged over 64 years. A series of 150 stroke patients was assessed on the scale, of whom 103 were aged over 64 years. Th...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/19.1.19

    authors: Lincoln NB,Edmans JA

    更新日期:1990-01-01 00:00:00

  • Lack of association between Helicobacter pylori infection and extracardiac atherosclerosis in dyspeptic elderly subjects.

    abstract:BACKGROUND:There are conflicting data on the association between Helicobacter pylori (HP) infection and cardiovascular diseases. AIM:To determine if there is an association between gastric HP infection and atherosclerosis of cerebral or peripheral arteries in elderly subjects. METHODS:90 dyspeptic elderly subjects ha...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/28.4.367

    authors: Pilotto A,Rumor F,Franceschi M,Leandro G,Novello R,Soffiati G,Scagnelli M,Di Mario F,Valerio G

    更新日期:1999-07-01 00:00:00