An unusual adverse reaction to self-medication with prednisone: an irrational crime during a fugue-state.

Abstract:

:During five years of self-medication with Prednisone, a forty-one-year old asthmatic businessman experienced periods of euphoria, psychomotor hyperactivity, and poor judgement; a period of depression and anxiety during temporary steroid withdrawal; and finally, with resumption of Prednisone, episodes of grandiosity and bizarre fugue-like behavior, with adoption of a second identity and culminating in an irrational crime. Steroids were then withdrawn, and the patient resumed his premorbid personality, but had amnesia for much of his previous behavior. The literature on hysterical fugues and corticosteroid-induced mental disturbance is reviewed. The patient's reactions are analyzed in terms of his premorbid neurotic conflicts, the psychological stresses acting upon him, and the effects of Prednisone on his central nervous system.

journal_name

Int J Psychiatry Med

authors

Gifford S,Murawski BJ,Kline NS,Sachar EJ

doi

10.2190/ygla-68km-q2vv-x03m

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

97-122

issue

2

eissn

0091-2174

issn

1541-3527

journal_volume

7

pub_type

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