Abstract:
:We have shown previously that plasmin facilitated the generation of long-term potentiation (LTP) in CA1 and dentate region of rat hippocampus. In the present study, we investigated the effects of plasmin on postsynaptic currents in CA1 pyramidal neurons of rat hippocampal slices. Plasmin (100 nM) had no effect on NMDA nor on non-NMDA receptor-mediated excitatory postsynaptic currents. However, plasmin significantly decreased GABA(A) receptor-mediated inhibitory postsynaptic currents. This effect of plasmin disappeared when intracellular Ca2+ was strongly chelated with BAPTA. Furthermore, plasmin attenuated the GABA-induced currents in CA1 pyramidal cells. These results suggest that the STP-enhancing effect of plasmin is due to a blockade of postsynaptic GABA(A) responses and that an increase in intracellular Ca2+ by plasmin may be involved in its mechanism.
journal_name
Brain Resjournal_title
Brain researchauthors
Mizutani A,Tanaka T,Saito H,Matsuki Ndoi
10.1016/s0006-8993(97)00338-7subject
Has Abstractpub_date
1997-06-27 00:00:00pages
93-6issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00338-7journal_volume
761pub_type
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