Postsynaptic blockade of inhibitory postsynaptic currents by plasmin in CA1 pyramidal cells of rat hippocampus.

Abstract:

:We have shown previously that plasmin facilitated the generation of long-term potentiation (LTP) in CA1 and dentate region of rat hippocampus. In the present study, we investigated the effects of plasmin on postsynaptic currents in CA1 pyramidal neurons of rat hippocampal slices. Plasmin (100 nM) had no effect on NMDA nor on non-NMDA receptor-mediated excitatory postsynaptic currents. However, plasmin significantly decreased GABA(A) receptor-mediated inhibitory postsynaptic currents. This effect of plasmin disappeared when intracellular Ca2+ was strongly chelated with BAPTA. Furthermore, plasmin attenuated the GABA-induced currents in CA1 pyramidal cells. These results suggest that the STP-enhancing effect of plasmin is due to a blockade of postsynaptic GABA(A) responses and that an increase in intracellular Ca2+ by plasmin may be involved in its mechanism.

journal_name

Brain Res

journal_title

Brain research

authors

Mizutani A,Tanaka T,Saito H,Matsuki N

doi

10.1016/s0006-8993(97)00338-7

subject

Has Abstract

pub_date

1997-06-27 00:00:00

pages

93-6

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(97)00338-7

journal_volume

761

pub_type

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