Abstract:
BACKGROUND:Subretinal hemorrhage in age related macular degeneration (AMD) usually causes acute visual loss and is associated with poor visual prognosis. In order to prevent retinal damage and to perform laser treatment of the underlying choroidal neovascularization (CNV) the subretinal hemorrhage has to be removed from the macular region. This could be achieved by intravitreal injection of tissue plasminogen activator (tPA) and gas. PATIENTS AND METHODS:In 8 consecutive patients, suffering from a massive macular hemorrhage (duration of visual problems: mean 9 days), tissue plasminogen activator (tPA) (40 micrograms in 400 microliters BSS) and SF6-gas (0.75 ml) was transsclerally injected into the vitreous cavity to achieve liquification and displacement of the hemorrhage. RESULTS:In all patients liquification and displacement of the hemorrhage out of the macular region was achieved during follow up. During the first week after operation a significant increase of visual acuity was noticed in all patients, however ophthalmoscopically there was just little reduction of the hemorrhage in the foveolar area. After successful removal of the blood the choroidal neovascularization was treated successfully by laser coagulation in one patient. No laser treatment was performed in the other patients because of the subfoveal location of the neovascularisation or because of disciform scar. Visual acuity increased 4 lines after surgery. In one case the procedure was complicated by a persistent vitreous hemorrhage and vitrectomy had to be performed in another patient due to an endophthalmitis. CONCLUSION:Intravitreal injection of tPA assisted gas displacement of subretinal hemorrhage due to AMD leads to a significant increase of visual acuity during the first week after operation. Although a nearly complete removal of the hemorrhage out of the macular area could be achieved, it was difficult to differentiate this from the spontaneous course. Laser photocoagulation could be performed in only few cases.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Framme C,Toukhy HE,Sachs HG,Spiegel D,Roider J,Gabel VP,Lohmann CPdoi
10.1055/s-2000-10513subject
Has Abstractpub_date
2000-01-01 00:00:00pages
33-9issue
1eissn
0023-2165issn
1439-3999journal_volume
216pub_type
杂志文章abstract::Anastomoses between vessels of the fundus may occur as congenital malformations or secondary to vascular diseases affecting the eye. Congenital anastomoses can be of the racemose hemangioma type, with severe malformation of the retinal vessels, ocular complications, and neurologic manifestations, or as simple A-V shun...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-10-01 00:00:00
abstract::In 40.8% of 169 eyes affected with diabetic preretinopathy (verified by fluorescein angiography) arteriovenous shunt vessels were found. These vessels occur with significant prevalence in eyes with areas of retinal capillary occlusions, and in cases with diabetes of long duration. There is strong evidence that AV shun...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057587
更新日期:1980-06-01 00:00:00
abstract::The position of the ophthalmologist as an unbiased and impartial expert in the field of tension between the client and the patient is a responsible task that should not be underestimated. Since the ophthalmological expert assessment often has far-reaching legal and financial consequences, it is very important that it ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0889-9523
更新日期:2019-04-18 00:00:00
abstract:BACKGROUND:The ongoing and fast evolution of foldable IOL designs established the necessity to evaluate the different abilities of each lens style. The large IOL database (over 16,500 specimens) acquired in our laboratory, has permitted us to perform a clinico-pathological analysis on pseudophakic autopsy globes provid...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2001-18386
更新日期:2001-10-01 00:00:00
abstract::We report on a 35 year old patient suffering from heterochromia complicata Fuchs with a mature cataract. Multiple small whitish-yellowish crystal-lines on the iris at the 7 and 12 o'clock position were interpreted as Russell bodies and correlated with an elevated concentration of 7.2 mg/dl IgG in the aqueous humor ana...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045953
更新日期:1991-03-01 00:00:00
abstract::Radiation Retinopathy is a progressive chronic disease triggered by ionising radiation and is characterised by vascular endothelial damage that can lead to macular edema, optic disc edema and proliferative retinopathy. We discuss a case of a patient with radiation retinopathy and optic disc edema who we treated with a...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0735-9865
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:A major focus of our study was to determine the value of postoperative intraocular pressure (IOP) in predicting the outcome of trabeculectomy (TE). PATIENTS AND METHODS:The medical charts of 547 patients undergoing glaucoma filtering surgery at the Department of Ophthalmology of the University of Cologne fr...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2000-10376
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:The application of anti fibroses agents during glaucoma surgery leads to more satisfactory results with lower i.o. pressure, yet eliciting complications in wound healing, avascular filtering blebs and frequent chronic hypotonias. In patients with lower risk for failure a reduction of concentration and applic...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035446
更新日期:1995-05-01 00:00:00
abstract::A 52-year-old woman contracted a serious influenza; three weeks later a dropshaped patch, whitish-yellow in color and deeply vascularized, was seen on the posterior upper surface of the cornea of one eye. It was accompanied by an anterior uveitis. The Tyndall phenomenon was positive. The sensibility of the upper quadr...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054449
更新日期:1984-03-01 00:00:00
abstract::We report on ten patients of four generations with autosomal dominant vitreoretinal dystrophy with different manifestation. The ophthalmological findings are retinal detachment, retinal holes, retinoschisis, lattice and snowflake degeneration, vitreoretinal adhesions, chorioretinal atrophy and peripheral pigment epith...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045954
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Due to theoretical considerations an increase in the depth of field of the diffractive IOL may be combined with a reduction in contrast sensitivity, glare sensitivity and colour perception. PATIENTS AND METHODS:A comparative analysis of both eyes was performed in ten patients with a diffractive multifocal I...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035495
更新日期:1994-01-01 00:00:00
abstract:PATIENT:A polycyclic lesion slightly prominent and yellowish in colour with a mulberry-like surface was incidentally detected in the left eye of a 69-year-old white female. It was located in the nasal horizontal sector of the fundus in a distance of about 5.5 mm from the optic disk. It was surrounded by a bright halo. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035428
更新日期:1995-03-01 00:00:00
abstract::In two groups of patients with two different posterior chamber intraocular lenses, very different correlations were found between postoperative and calculated anterior chamber depth, and between postoperative anterior chamber depth and axial length. Since it has long been known that there are positive correlations bet...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046396
更新日期:1989-06-01 00:00:00
abstract::Two pairs of albinotic brothers, a severely myopic albino and an aged albinotic woman patient were examined; visual acuity was 0.2. In the nystagmogram there were varied rhythmic wave-forms with 1) oscillations of high frequency; 2) slow arrhythmic movements; 3) deviation tendencies with a fast nystagmus component. In...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057553
更新日期:1980-05-01 00:00:00
abstract:PATIENTS AND METHODS:In 28 patients after perforating keratoplasty followed by epithelial abrasion of the transplant the period required for epithelial closure with a therapy including collagen shields and the growth stimulating factors vitamin A and Epidermal Growth Factor (EGF) was determined. RESULTS:A significant ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2008-1045517
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:To report the clinical effect of oral voriconazole only as a treatment for fungal keratitis. HISTORY AND SIGNS:Three patients (1 female and 2 males) with culture-proven fungal keratitis (1 Mucoraceae, 1 Aspergillus, 1 Fusarium) were included in this study. The patients were treated with oral voriconazole 20...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-1268-9168
更新日期:2021-01-01 00:00:00
abstract::Whereas by far not all properties of the crystalline lens can be realized with an artifical intraocular lens, maximal stability of such a device is its most important feature. The latter can be achieved by the adherence of the lens to the capsular membrane, left behind after extra-capsular cataract extraction. In this...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:The purpose of this investigation was to analyse the ophthalmic follow-up care of former pre-term and full-term born infants aged 4 to 10 years in the clinical practice and the comparison to the recommendations of the national ophthalmic guidelines. METHODS:For the prospective Wiesbaden Prematurity Study (W...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0043-118852
更新日期:2019-10-01 00:00:00
abstract::For the first time two cases are described with disturbances of binocular vision caused by subjective perception of positive scotomata in the amblyopic eye. The visual strain of working at a terminal leads to a slight increase in the squint angle; as a result, a paracentral scotoma may shift into the middle of the bin...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054340
更新日期:1985-11-01 00:00:00
abstract::This is a rare auto-immune illness with necrosis of cartilages. Palpebral oedema, conjunctivitis, episcleritis, iridocyclitis and proptosis belong to this syndrom. But the cataracts often described are iatrogenic, due to the intense corticotherapy required. A report is given of one personal observation and discussion ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
abstract::The tearing eye (epiphora) is the guiding symptome of nasolacrimal duct obstruction. Depending on the localization of stenosis, mucopurulent lacrimal discharge occurs additionally. These symptoms induce alterations of the optical system and can cause severe complications such as acute phlegmonous dacryocystitis. The g...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-1283-9271
更新日期:2020-11-18 00:00:00
abstract:PURPOSE:Active HCO3- transport through the corneal endothelial cell layer causes a dehydration of the corneal stroma and is thought to be driven by Na/K- and HCO3(-)-dependent ATPase as well as an electro-genic Na/HCO3- cotransport. Transmembrane bicarbonate transport has also been associated with the recently characte...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1034787
更新日期:1999-05-01 00:00:00
abstract:INTRODUCTION:Until now, venous pressure within the eye has widely been equated with intraocular pressure (IOP). Measurements with dynamometers calibrated in instrument units or in force showed that the retinal venous pressure (RVP) may be higher than the IOP in glaucoma patients. In this study, the RVP was measured wit...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-1318-9991
更新日期:2021-01-12 00:00:00
abstract:PURPOSE:In 40% retinoblastoma (Rb) results from a hereditary mutation of the Rb susceptibility gene (RB1). In this study, we tested the usefulness of intragenic DNA analysis for ophthalmologic follow-up in affected families. METHODS:Molecular analysis was performed on 103 DNA samples of 15 Rb families. We used 7 intra...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035456
更新日期:1995-05-01 00:00:00
abstract::Noninfectious ulceration of the peripheral cornea remains a major diagnostic and therapeutic challenge. The pathogenesis in most of these disorders is unclear, however, on the basis of systemic connective tissue diseases, autoimmune mechanisms are most likely involved. The peripheral cornea has distinct morphological ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1035173
更新日期:1996-02-01 00:00:00
abstract::In the EU more than 70 % of national law has already been replaced by EU law. Medical doctors are mostly not informed, how these EU-laws will pass. Many directives, regulations and decisions are important for medical doctors. A characterization of the EU- institutions is represented. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2005-858749
更新日期:2005-11-01 00:00:00
abstract::In the literature two types of anterior corneal dystrophy are referred to as Reis-Bücklers' dystrophy. These are the one originally described by Bücklers in 1949 and known by us as the geographical form, and a honeycomb form. On the basis of electron-microscopic findings the geographical form is considered by some aut...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050600
更新日期:1986-02-01 00:00:00
abstract::In 22 open-angle glaucoma patients a total of 39 eyes were treated with Timolol 0.25% twice daily for an average period of 12.6 months. The relative intraocular pressure decrease at the beginning of the study was 47% of the untreated pressure level. This initial response declined to a 23% pressure decrease at the end ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-11-01 00:00:00
abstract:BACKGROUND:In strabismus surgery the challenge is the preoperative determination of the surgical dosage. We assessed the long-term follow-up after strabismus surgery for exodeviations and evaluated the employed dosage. PATIENTS AND METHODS:We present a study of 53 consecutive patients who underwent surgery for exodevi...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章
doi:10.1055/s-0028-1109265
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:In the city of Zurich, vision screening is performed by school medical services as part of the legally compulsory preventive medical examinations. We retrospectively evaluated the results of the 2011-2012 school year. PATIENTS AND METHODS:Preventive medical examinations by the school medical services were p...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0041-111818
更新日期:2016-04-01 00:00:00