gamma-Pyrones from Gonystylus keithii, as new inhibitors of parathyroid hormone (PTH)-induced Ca release from neonatal mouse calvaria.

Abstract:

:New gamma-pyrones, 9'-oxopodopyrone (3) and 8-methyl-9'-oxopodopyrone (4) were isolated from the leaves of Gonystylus keithii, along with known gamma-pyrones, 10'-oxopodopyrone (1) and 8-methyl-10'-oxopodopyrone (2). These gamma-pyrones markedly inhibited the bovine parathyroid hormone (PTH)-induced Ca release from neonatal mouse calvaria in vitro. It is the first time that gamma-pyrones showed inhibitory effects on bone resorption, and these compounds may be seed compounds of new drugs for osteoporosis.

authors

Kanazawa T,Ohkawa Y,Kuda T,Minobe Y,Tani T,Nishizawa M

doi

10.1248/cpb.45.1046

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

1046-51

issue

6

eissn

0009-2363

issn

1347-5223

journal_volume

45

pub_type

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