Abstract：
:The liquid ventilation (LV) technique was previously demonstrated to be a valuable alternative to ordinary gas ventilation, particularly for newborn patients with severely distressed lungs. This work describes a mathematical model of gas transfer phenomena occurring within the lungs of a preterm newborn baby ventilated with liquid perfluorocarbon (PFC) RM-101. The model was conceived in order to perform computer simulations of LV treatments. Its input parameters are tidal volume, respiratory frequency, oxygen and carbon dioxide tension in inlet PFC; its output data are the partial pressures of respiratory gases in the alveolar environment. Such values may be evaluated at any instant from the beginning of the treatment, in order to judge whether the therapy is able to meet the necessary conditions to arterialize properly the patient's venous blood. The model also enables optimisation procedures to be defined and performed. Quantitative results and graphs are supplied, with reference to the simulation of LV applied to a preterm newborn of 28 gestational weeks. The main results point out that a relatively short duration of initial transients is attainable (200 to 240 s) and that blood arterialization is possible even with low oxygen tension in inlet PFC (29.7 kPa (223 mmHg)).
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Costantino ML,Fiore GBdoi
10.1016/s1350-4533(96)00041-0subject
Has Abstractpub_date
1997-03-01 00:00:00pages
157-63issue
2eissn
1350-4533issn
1873-4030pii
S1350-4533(96)00041-0journal_volume
19pub_type
杂志文章abstract：:Currently, a number of studies focus on the study and design of new healthcare technologies to improve elderly health and quality of life. Taking advantage of the popularity, portability, and inherent technology of smartphones, we present an emergency application for smartphones, designated as knock-to-panic (KTP). Th...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.05.002
更新日期：2016-09-01 00:00:00
abstract：:Intravascular stents are small tube-like structures expanded into stenotic arteries to restore blood flow perfusion to the downstream tissues. The stent expansion is an important factor to define the effectiveness of the surgical procedure: it depends on the stent geometry and includes large displacements and deformat...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2004.08.012
更新日期：2005-01-01 00:00:00
abstract：:Intradialytic hypotension (IDH) is a major complication during hemodialysis treatment, and therefore it is highly desirable to identify, at an early stage during treatment, whether the patient is prone to IDH. Heart rate variability (HRV), blood pressure variability (BPV) and baroreflex sensitivity (BRS) were analyzed...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2015.10.003
更新日期：2015-12-01 00:00:00
abstract：:This paper investigates the possibility of characterizing the differences between normal- and high-risk postoperative cardiac patients on the basis of four parameters related to a simple linear model of cardiorespiratory performances. The model comprises three subsystems representing cardiac, vascular and respiratory ...
journal_title：Medical engineering & physics
pub_type： 临床试验,杂志文章
doi：10.1016/1350-4533(94)90073-6
更新日期：1994-11-01 00:00:00
abstract：:Accurate models of bone shapes are essential for orthopaedic reconstructions. The commonly used methods of using the contralateral side requires an intact bone and anatomical symmetry. Recent studies have shown that statistical shape and appearance models (SSAMs) as an alternative can predict accurate geometric models...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.03.007
更新日期：2019-05-01 00:00:00
abstract：:Fitts' Law was extended in the polar coordinate system, and a set of indices for human motion evaluation is proposed. In this paper, the index of difficulty and the index of performance are introduced as the general indices for the quality measure of plane target-to-target movement. As an example, the target-reaching ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(01)00121-7
更新日期：2002-03-01 00:00:00
abstract：:Finite element (FE) models of the proximal femur are often used to study hip fracture. To interpret the results of these models, it is important to know whether the models accurately predict fracture location and/or type. This study evaluated the ability of automatically generated, CT scan-based linear FE models of th...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(01)00094-7
更新日期：2001-11-01 00:00:00
abstract：:Lateral epicondylitis (LE) is hypothesized to occur as a result of repetitive, strenuous and abnormal postural activities of the elbow and wrist. There is still a lack of understanding of how wrist and forearm positions contribute to this condition during common manual tasks. In this study the wrist kinematics and the...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.02.002
更新日期：2011-07-01 00:00:00
abstract：:Miniaturized and parallelized sandwich immunoassays allow the simultaneous analysis of a variety of parameters in a single experiment. Bead-based protein array systems or suspension microarrays are well-established multiplex sandwich immunoassay formats. To study inflammatory diseases, protein arrays can be used to an...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2008.01.003
更新日期：2008-10-01 00:00:00
abstract：:This paper describes a novel three-wire thermal flow sensor for medical applications. The present innovation for low-frequency measurements involves the use of a pulsed-wire anemometer with a comparatively large wire diameter (12.5 microm and larger) together with a novel signal processing approach. A small wire is he...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2004.06.002
更新日期：2004-10-01 00:00:00
abstract：:Kinematic parameters for 10 normal subjects and 10 patients with ankle arthrodesis are grouped using the fuzzy cluster paradigm. The features chosen for clustering are Euler angles of the sagittal plane in the hindfoot, the forefoot and combined hindfoot and forefoot joints. Gait patterns are identified using informat...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(01)00020-0
更新日期：2001-03-01 00:00:00
abstract：:Electrochemotherapy (ECT) exploits the phenomenon of electroporation, which is the increase of cell permeability through the application of an electrical field. This technique is applied in medical centers in Europe and in veterinary clinics in Europe, Brazil, and Argentina. ECT treatment requires a minimum electric f...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2019.09.016
更新日期：2019-12-01 00:00:00
abstract：:To determine the reliability, stability, validity and precision of a stereophotogrammetry (SP) system for use in quantifying the complex three-dimensional structure of the human torso, we performed assessments of the system using images of geometric solids and a human-form mannequin. Analysis of geometric solids revea...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2009.08.011
更新日期：2009-12-01 00:00:00
abstract：:Investigations into the effects of sterilization on a new biomechanical pressure sensor are necessary before contemplating in vivo use. Ten, designated Experimental, "K-Scan" digital pressure sensor arrays were sterilized with ethylene oxide gas (EtO), and their ability to accurately and reproducibly measure an applie...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(03)00119-x
更新日期：2003-11-01 00:00:00
abstract：:The second-order difference plot, as a modified Poincaré plot, is one of the important approaches for assessing the dynamics of heart rate variability. However, corresponding quantitative analysis methods are relatively limited. Based on the second-order difference plot, we propose a novel method, called the multi-sca...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2014.09.015
更新日期：2014-12-01 00:00:00
abstract：:Complex congenital heart defects due to the absence of a ventricular chamber can often be treated by the Fontan surgical procedure. The objective of this work was to quantify the haemodynamics in the Fontan operation (cavopulmonary connection) with extracardiac lateral conduit. Four different models based on the finit...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(99)00042-9
更新日期：1999-04-01 00:00:00
abstract：:There are several issues attributed with abdominal aortic aneurysm endovascular repair. The positioning of bifurcated stent-grafts (SG) may affect SG hemodynamics. The hemodynamics and geometrical parameters of crossing or non-crossing graft limbs have not being totally accessed. Eight patient-specific SG devices and ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.09.011
更新日期：2016-12-01 00:00:00
abstract：:Complications arising from limb-lengthening procedures such as muscle contracture, axial malalignment of the bone and traction injuries to the nerves and vessels, are often severe. Often complications arise from the build-up of forces in the biological tissues which are resisting lengthening. Little is known about the...
journal_title：Medical engineering & physics
pub_type： 临床试验,杂志文章
doi：10.1016/s1350-4533(97)00010-6
更新日期：1997-07-01 00:00:00
abstract：:On the computational basis of a neurodynamical cortical model, we investigate a specific top-down visual cognitive impairment in brain-damaged patients known as visual spatial neglect. The computational cortical model accounts the neurodynamics underlying selective visual attention, is based on the "biased competition...
journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
doi：10.1016/j.medengphy.2004.06.011
更新日期：2004-11-01 00:00:00
abstract：:Cerebral autoregulation (CA) is the mechanism that aims to maintain adequate cerebral perfusion during changes in blood pressure (BP). Transfer function analysis (TFA), the most reported method in literature to quantify CA, shows large between-study variability in outcomes. The aim of this study is to investigate the ...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.02.001
更新日期：2016-05-01 00:00:00
abstract：:We studied muscle fatigue in 19 paraplegic patients during an isometric sustained contraction. Both quadriceps (n = 38) were maximally stimulated for 126 s. We defined a nonlinear equation with four coefficients to fit the data and extract fatigue indices carrying information on the amount (asymptotic values, torque c...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(97)00038-6
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:Verified and validated CT-based high-order finite element (FE) methods were developed that predict accurately the mechanical response of patient-specific intact femurs. Here we extend these capabilities to human femurs undergoing a total hip replacement using cemented prostheses. METHODS:A fresh-frozen huma...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2012.09.007
更新日期：2013-07-01 00:00:00
abstract：:Foot pressure ulcers are a common complication of diabetes because of patient's lack of sensitivity due to neuropathy. Deep pressure ulcers appear internally when pressures applied on the foot create high internal strains nearby bony structures. Monitoring tissue strains in persons with diabetes is therefore important...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2016.04.017
更新日期：2016-09-01 00:00:00
abstract：:Scoliosis is a 3D deformity of the spine and rib cage. Extensive validation of 3D reconstruction methods of the spine from biplanar radiography has already been published. In this article, we propose a novel method to reconstruct the rib cage, using the same biplanar views as for the 3D reconstruction of the spine, to...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2013.06.002
更新日期：2013-11-01 00:00:00
abstract：:Improper design of vertebral body cages may seriously affect the interface strength and cause the lose of fixation for a vertebral body replacement. This research used a FEM-based Taguchi method to investigate the effects of various factors to find the robust design of the body cage. Three-dimensional finite element m...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2008.07.001
更新日期：2009-04-01 00:00:00
abstract：:Recently, surgeons have begun to treat serious congenital craniofacial deformities including craniosynostoses with mechanical devices that gradually distract the skull. As a prospective means of treatment planning for such complex deformities, FE models derived from routine preoperative CT scans (CT/FEA) would provide...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/s1350-4533(98)00053-8
更新日期：1998-11-01 00:00:00
abstract：:The incudostapedial joint (ISJ) is a synovial joint connecting the incus and stapes in the middle ear. Mechanical properties of the ISJ directly affect sound transmission from the tympanic membrane to the cochlea. However, how ISJ properties change with frequency has not been investigated. In this paper, we report the...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2018.02.006
更新日期：2018-04-01 00:00:00
abstract：:Recent research has indicated that consumers of upper limb prostheses desire lighter-weight, anthropomorphic devices. The potential of dielectric elastomer (DE) actuators to better meet the design priorities of prosthesis users is explored. Current challenges are critically reviewed with respect to (1) durability, (2)...
journal_title：Medical engineering & physics
pub_type： 杂志文章,评审
doi：10.1016/j.medengphy.2007.05.011
更新日期：2008-05-01 00:00:00
abstract：INTRODUCTION:A notable characteristic of bariatric surgery is the frequent manipulation of the bowel. The bowel is large, delicate, flexible, and has a natural lubricant on the tissue surface. Therefore the bowel is difficult to grasp and manipulate. Vacuum technique is commonly used in industry for all types of graspi...
journal_title：Medical engineering & physics
pub_type： 杂志文章
doi：10.1016/j.medengphy.2011.11.014
更新日期：2012-10-01 00:00:00
abstract：:Two quantitative techniques have been evaluated to examine whether respiratory sinus arrhythmia can be detected in atrial fibrillation. Cyclical changes in heart rate during deep breathing indicating respiratory sinus arrhythmia were seen in 11/15 control patients, but only 1/44 patients with atrial fibrillation. Powe...
journal_title：Medical engineering & physics
pub_type： 临床试验,杂志文章
doi：10.1016/1350-4533(94)90061-2
更新日期：1994-07-01 00:00:00
