当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Cloning and characterization of the 5'-flanking region of the human dopamine D4 receptor gene.

Cloning and characterization of the 5'-flanking region of the human dopamine D4 receptor gene.

Abstract：

:Dopamine D4 receptor (DRD4) has received attention in terms of pathogenesis of schizophrenia and association with human personalities. We isolated the human DRD4 gene containing the 5'-flanking region and determined its sequence. Analysis of the DRD4 transcripts by 5'-RACE (5'-rapid amplification of cDNA ends) revealed a region of the transcription initiation located between -501 and -436 relative to the first nucleotide of the initiation codon. There is a CpG island spanning from -900 to +500 but no TATA or CAAT boxes in the 5'-flanking region. Functional analysis of the 5'-flanking region of the DRD4 gene by a transient expression method revealed the presence of a negative modulator between -770 and -679. The region between -591 and -123 gave the highest transcriptional activity in IMR32 (neuroblastoma) and Y-79 (retinoblastoma) cells but not in HeLa cells, suggesting that this housekeeping gene-like promoter regulates the cell-type specific gene expression.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kamakura S,Iwaki A,Matsumoto M,Fukumaki Y

doi

10.1006/bbrc.1997.6770

subject

Has Abstract

pub_date

1997-06-18 00:00:00

pages

321-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)96770-X

journal_volume

235

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Combination of the chemotherapeutic agent 5-fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction.

    abstract：:The rate limiting step in 5-fluorouracil catabolism is catalyzed by the enzyme dihydropyrimidine dehydrogenase. Since degradation of 5-fluorouracil decreases its efficacy in chemotherapy, the inhibition of its catabolism is a promising tool. We investigated the formation of micronuclei in vitro in mouse L5178Y cells. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2299

    authors： Stopper H,Kühnel A,Podschun B

    更新日期：1994-09-15 00:00:00

  • Regulation of ERK1/2 activity upon contact inhibition in fibroblasts.

    abstract：:Contact inhibition is a crucial mechanism regulating proliferation in vitro and in vivo. Despite its generally accepted importance for maintaining tissue homeostasis knowledge about the underlying molecular mechanisms of contact inhibition is still scarce. Since the MAPK ERK1/2 plays a pivotal role in the control of p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.02.080

    authors： Küppers M,Faust D,Linz B,Dietrich C

    更新日期：2011-03-18 00:00:00

  • Neutrophil activation by surface bound IgG is via a pertussis toxin insensitive G protein.

    abstract：:Pre-treatment of neutrophils with either pertussis or cholera toxins does not inhibit neutrophil activation by surface bound IgG. In contrast, pretreatment with the phorbol ester, phorbol myristate acetate, results in a dose dependent inhibition of degranulation by surface bound IgG. This inhibition is similar to that...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91766-x

    authors： Blackburn WD Jr,Heck LW

    更新日期：1989-11-15 00:00:00

  • Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients.

    abstract：:The peptidyl-prolyl isomerase Pin1 is prevalently overexpressed in human cancers and is regarded as a new diagnostic and therapeutic target. Pin1 interacts with several proteins involved in cell cycle events in a phosphorylation-dependent manner. Among them, NIMA (never in mitosis, gene A) was first identified to inte...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.228

    authors： Chen J,Li L,Zhang Y,Yang H,Wei Y,Zhang L,Liu X,Yu L

    更新日期：2006-03-24 00:00:00

  • A cytoplasmic nickel-iron hydrogenase with high specific activity from Desulfovibrio multispirans sp. N., a new species of sulfate reducing bacterium.

    abstract：:A hydrogenase from a new species of sulfate reducing bacterium has been isolated and characterized. In contrast to other hydrogenases isolated from Desulfovibrio, this enzyme is found in the cytoplasmic fraction rather than in the periplasm. The specific activity of the enzyme, as measured in the hydrogen evolution as...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91386-x

    authors： Czechowski MH,He SH,Nacro M,DerVartanian DV,Peck HD Jr,LeGall J

    更新日期：1984-12-28 00:00:00

  • Amblyomma americanum salivary gland homolog of nSec1 is essential for saliva protein secretion.

    abstract：:Soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins assemble in tight core complexes which promote fusion of carrier vesicles with target compartments. Members of this class of proteins are expressed in all eukaryotic cells and distributed in distinct subcellular compartments. All vesicle tr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.09.189

    authors： Karim S,Ramakrishnan VG,Tucker JS,Essenberg RC,Sauer JR

    更新日期：2004-11-26 00:00:00

  • Methylation of human ornithine decarboxylase gene before transfection abolishes its transient expression in Chinese hamster ovary cells.

    abstract：:Different methylations of cloned human ornithine decarboxylase gene with restriction methylases in vitro before transfection greatly reduced the transient expression of ODC in Chinese hamster ovary cells. Single methylation of the gene with Hpa II (CCGG) methylase decreased the transiently expressed peak activity by a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92029-9

    authors： Halmekytö M,Hirvonen A,Wahlfors J,Alhonen L,Jänne J

    更新日期：1989-07-14 00:00:00

  • Hydrophobic moieties in cations, anions, and alcohols promote the B-to-Z transition in poly[d(G-C)] and poly[d(G-m5C)].

    abstract：:Previous results from our laboratory showed that an increase in the nonpolar alkyl chain length in tetraalkylammonium cations is accompanied by greater efficiency in driving the B-to-Z transition. Analogous effects are observed when the hydrocarbon portion of carboxylate anions and alcohols is increased in size. The m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91737-3

    authors： McDonnell NB,Preisler RS

    更新日期：1989-10-16 00:00:00

  • Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells.

    abstract：:Oxidative stress induced by hyperglycemia is a key factor in the development of cardiovascular diseases in diabetes. Thioredoxin (Trx) system, a major thiol antioxidant system, regulates the reduction of intracellular reactive oxygen species (ROS). In this study, we demonstrated that high glucose significantly increas...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.02.132

    authors： Li X,Rong Y,Zhang M,Wang XL,LeMaire SA,Coselli JS,Zhang Y,Shen YH

    更新日期：2009-04-17 00:00:00

  • Ca2+-dependent binding of calcyclin to muscle tropomyosin.

    abstract：:The interaction of calcyclin with tropomyosin and tropomyosin-actin was studied with fluorescence titrations and photo-reactive crosslinking experiments. Titrations of pyreneiodoacetamide-labeled tropomyosin alone or with actin showed binding of calcyclin to tropomyosin with muM dissociation constants when Ca2+ was pr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0410

    authors： Golitsina NL,Kordowska J,Wang CL,Lehrer SS

    更新日期：1996-03-18 00:00:00

  • Effect of rec mutations on viability and processing of DNA damaged by methylmethane sulfonate in xth nth nfo cells of Escherichia coli.

    abstract：:The role of recombination genes in the processing of DNA damaged by methlymethane sulfonate (MMS) was examined in an xth nth nfo strain of Escherichia coli K-12. Introduction of a recQ mutation did not increase the cell's sensitivity to MMS treatment. The presence of recF, recJ or recN mutation slightly increased the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81132-5

    authors： Wang TC,Chang HY

    更新日期：1991-10-31 00:00:00

  • NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages.

    abstract：:The ability of exogenous nitric oxide (NO) to induce apoptosis in macrophages was analyzed using NOC, a NO-releasing compound, as a source of NO. Exogenous NO was shown to induce apoptosis in a dose dependent manner. Quantitative analysis revealed that the amount of NO required to induce apoptosis in more than half of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1532

    authors： Shimaoka M,Iida T,Ohara A,Taenaka N,Mashimo T,Honda T,Yoshiya I

    更新日期：1995-04-17 00:00:00

  • Simultaneous detection of thiamine and its phosphate esters from microalgae by HPLC.

    abstract：:We present an easy and sensitive method for measuring thiamine and its phosphate esters in small biological samples of microalgae (Amphidinium carterae Hulburt and Nitzschia microcephala Grun). The method consists of extraction of thiamine and its derivatives in acid solution, followed by liquid chromatography with fl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6438

    authors： Pinto E,Pedersén M,Snoeijs P,Van Nieuwerburgh L,Colepicolo P

    更新日期：2002-02-22 00:00:00

  • An endoribonuclease activity associated with Lettre Ehrlich ascites tumor cell mitochondria.

    abstract：:The splicing of 3.36kb mouse mitochondrial mRNA precursor(L-strand) to 69bp RNA component is shown to be mediated by an endoribonuclease activity associated with Lettre Ehrlich ascites tumor cell mitochondria. The enzymic activity was partially purified by column chromatography and the in vitro reconstituted RNA proce...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2214

    authors： Bhattacharya P

    更新日期：1993-10-15 00:00:00

  • Overexpression of glia maturation factor in astrocytes leads to immune activation of microglia through secretion of granulocyte-macrophage-colony stimulating factor.

    abstract：:We infected a mixed culture of primary rat astrocytes and microglia with a replication-defective adenovirus carrying the rat glia maturation factor (GMF) cDNA. Affymetrix microarray analysis showed a big increase in the expression of several major histocompatibility complex (MHC) class II proteins along with interleuk...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00467-9

    authors： Zaheer A,Mathur SN,Lim R

    更新日期：2002-06-07 00:00:00

  • Developmental changes in the structural organization of the lectin discoidin I detected by limited proteolysis.

    abstract：:Digestion of discoidin I with several proteolytic enzymes reveals the existence of structural domains in this lectin. Significative differences have been detected in the pattern of fragments generated by V8 protease on discoidin I of various developmental situations. The changes observed can be related to the presence...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80431-5

    authors： Valencia A,Pestaña A,Cano A

    更新日期：1988-05-16 00:00:00

  • Monte Carlo studies of lipid chains and gramicidin A in a model membrane.

    abstract：:The Monte Carlo method has been used to simulate the equilibrium properties of a planar array of 94 saturated lipid chains and one monomer of Gramicidin A. Chains are free to move laterally in the layer plane and to change conformation via gauche rotations and long axis rotations in a continuum. All non-hydrogen atoms...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91025-5

    authors： Xing J,Scott HL

    更新日期：1989-11-30 00:00:00

  • Effects of high fat diet on GPR109A and GPR81 gene expression.

    abstract：:GPR109A (PUMA-G, NIACR1, HCA(2)) and GPR81 (HCA(1)) are G protein-coupled receptors located predominantly on adipocytes that mediate anti-lipolytic effects. These cell surface receptors give the adipocyte the ability to "sense" metabolic changes in the environment and respond through lipolytic regulation and release o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.07.082

    authors： Wanders D,Graff EC,Judd RL

    更新日期：2012-08-24 00:00:00

  • p73-dependent induction of 14-3-3sigma increases the chemo-sensitivity of drug-resistant human breast cancers.

    abstract：:It has been well documented that tumor suppressor p53 is mutated in about 50% of all human tumors. p53 status might be one of the critical determinants for the chemo-sensitivity of human tumors. In the present study, we have found that p53 family member p73 as well as 14-3-3sigma is down-regulated in response to adria...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.079

    authors： Sang M,Li Y,Ozaki T,Ono S,Ando K,Yamamoto H,Koda T,Geng C,Nakagawara A

    更新日期：2006-08-18 00:00:00

  • Synergistic regulation of the mouse orphan nuclear receptor SHP gene promoter by CLOCK-BMAL1 and LRH-1.

    abstract：:Small heterodimer partner (SHP; NR0B2) is an orphan nuclear receptor and acts as a repressor for wide variety of nuclear hormone receptors. We demonstrated here that mouse SHP mRNA showed a circadian expression pattern in the liver. Transient transfection of the mSHP promoter demonstrated that CLOCK-BMAL1, core circad...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.131

    authors： Oiwa A,Kakizawa T,Miyamoto T,Yamashita K,Jiang W,Takeda T,Suzuki S,Hashizume K

    更新日期：2007-02-23 00:00:00

  • Factor C-LHIH which inhibits the luteinizing hormone from basal release and from synthetic LHRH and studies on purification of FSHRH.

    abstract：:Data on a new entity which inhibits the release of luteinizing hormone (LH), designated as factor C-LHIH, are presented. In vitro assays were carried out with pituitary glands from female rats. Factor C-LHIH and follicle stimulating hormone releasing hormone (FSHRH) initially fractionated together. FSHRH obscured C...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(75)80011-8

    authors： Johansson KN,Greibrokk T,Currie BL,Hansen J,Folkers K

    更新日期：1975-03-03 00:00:00

  • Molecular characterization of the 56-kDa CYP153 from Acinetobacter sp. EB104.

    abstract：:CYP153 a cytochrome P450 from Acinetobacter sp. EB104 catalyzes the hydroxylation of unsubstituted n-alkanes. We have decided to use the CYP153 system as a model for mechanistic studies on regioselective n-alkane oxidation and the interaction of hydrophobic substrates with soluble enzymes. Here the molecular cloning o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5449

    authors： Maier T,Förster HH,Asperger O,Hahn U

    更新日期：2001-08-24 00:00:00

  • Identification and characterization of the zinc finger protein SjZF in Schistosoma japonicum.

    abstract：:Schistosomiasis represents one of the most prevalent parasitic infections affecting over 249 million people worldwide. The pathological damage is mainly caused by the eggs laid by female schistosomes. Zinc finger proteins (ZFPs) usually play critical roles in many biological functions. In this study, we cloned, identi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.05.083

    authors： Zhang R,Li J,Xiang M,Hong Q,Xu B,Hu W

    更新日期：2018-07-02 00:00:00

  • Association of endogenous synenkephalin containing peptides with intracellular membranes of bovine adrenal medulla.

    abstract：:The association of endogenous synenkephalin and met-enkephalin containing peptides with the membrane of bovine chromaffin granules and physicochemical characteristics of this association were studied. The associated materials were only released at a non physiological pH range and this effect was enhanced with growing ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92791-5

    authors： Ase A,Vindrola O,Aloyz R,Inés M,Vida R,Finkielman S,Nahmod V

    更新日期：1989-02-15 00:00:00

  • Loss of O-GlcNAc transferase in neural stem cells impairs corticogenesis.

    abstract：:The proper development of the cerebral cortex is essential for brain formation and functioning. O-GlcNAcylation, an important posttranslational modification, regulates the pathways critical for neuronal health and the survival of the cerebral cortex in neurodegenerative diseases. However, the role of O-GlcNAcylation i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.08.084

    authors： Cheng J,Wu Y,Chen L,Li Y,Liu F,Shao J,Huang M,Fan M,Wu H

    更新日期：2020-11-19 00:00:00

  • Current perspectives of molecular pathways involved in chronic inflammation-mediated breast cancer.

    abstract：:Inflammation has multifaceted role in cancer progression including initiation, promotion and invasion by affecting the immune surveillance and associated signaling pathways. Inflammation facilitates the over-expression of cytokines, chemokines and growth factors involved in progression of different cancers including b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2015.10.133

    authors： Suman S,Sharma PK,Rai G,Mishra S,Arora D,Gupta P,Shukla Y

    更新日期：2016-04-08 00:00:00

  • Glycogen-storage disease type II (acid maltase deficiency): identification of a novel small deletion (delCC482+483) in French patients.

    abstract：:Glycogen-storage disease type II (GSD II, acid maltase deficiency, Pompe's disease) is caused by defects in the lysosomal acid alpha-glucosidase (GAA) gene. Clinically, patients with the severe infantile form of GSD II have muscle weakness and cardiomyopathy eventually leading to death before the age of two years. Pat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6749

    authors： Nicolino M,Puech JP,Letourneur F,Fardeau M,Kahn A,Poenaru L

    更新日期：1997-06-09 00:00:00

  • Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26).

    abstract：:The peroxidative activation of the antitumor drugs, etoposide (VP-16) and teniposide (VM-26), has been studied in vitro. Both of these drugs, in the presence of horseradish peroxidase or prostaglandin synthetase, formed phenoxy radical intermediates. Furthermore, this activation also resulted in the formation of two m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90965-4

    authors： Haim N,Roman J,Nemec J,Sinha BK

    更新日期：1986-02-26 00:00:00

  • The involvement of an LPS inducible I kappa B kinase in endotoxin tolerance.

    abstract：:When human ovarian carcinoma cells are challenged with endotoxin, an I kappa B kinase is transiently induced within 3 to 5 min. This enzyme activity causes the hyperphosphorylation and subsequent degradation of I kappa B which allows NF-kappa B to translocate to the nucleus where it activates transcription. When endot...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6337

    authors： Kohler NG,Joly A

    更新日期：1997-03-27 00:00:00

  • Diphenyleneiodonium enhances oxidative stress and inhibits Japanese encephalitis virus induced autophagy and ER stress pathways.

    abstract：:Diphenyleneiodonium (DPI) and N-acetyl-l-cysteine (NAC), two widely used anti-oxidants, were employed to evaluate the role of oxidative stress in Japanese encephalitis virus (JEV) induced autophagy, stress responses and replication. DPI and NAC exerted opposite effects on ROS levels in JEV infected mouse neuronal cell...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.05.149

    authors： Sharma M,Sharma KB,Chauhan S,Bhattacharyya S,Vrati S,Kalia M

    更新日期：2018-07-12 00:00:00