Neonatal whole blood hyperviscosity: the important factor influencing later neurologic function is the viscosity and not the polycythemia.

Abstract:

:The neurologic outcome of 23 seven-year old children who had cord blood hyperviscosity was compared with that of children with normal cord blood viscosity in a randomised, controlled and blinded study. Viscosity was measured using a coaxial narrow-gap couette viscometer. Sixteen (69.6%) of the children with hyperviscous cord blood had a disability; this incidence being three times greater (22.7%) than in children whose cord blood was not hyperviscous (P < 0.01). In three children with cord-blood hyperviscosity, the disability was severe. No child had a severe disability with normal cord blood viscosity. Of the eight children whose cord blood was hyperviscous, but not polycythemic, six (75.0%) had a disability and in one child the disability was severe. These results demonstrate an association between cord blood hyperviscosity and later neurologic development. Cord studies are non-invasive and result in the rapid diagnosis of the neonatal hyperviscosity syndrome, so allowing earlier treatment. This may be crucial in altering the effects of hyperviscosity on the developing brain in the early neonatal period. Because the neurologic outcome of children was similar whether polycythemia was present or not, the prime factor was the viscosity and not the hematocrit level. We suggest it may be necessary to perform cord blood viscosity studies routinely.

authors

Drew JH,Guaran RL,Cichello M,Hobbs JB

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

67-72

issue

1

eissn

1386-0291

issn

1875-8622

journal_volume

17

pub_type

临床试验,杂志文章,随机对照试验
  • Red blood cell deformability, aggregability and cytosolic calcium concentration in normal tension glaucoma.

    abstract:AIM:The aim of the study was to determine the role of some erythrocyte patterns (Red Blood Cell deformability, aggregability, cytosolic calcium concentration) in normal tension glaucoma (NTG), compared with primary open angle glaucoma (POAG) and normal subjects. MATERIAL AND METHODS:Ninety patients entered the study, ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Vetrugno M,Cicco G,Cantatore F,Arnese L,Delle Noci N,Sborgia C

    更新日期:2004-01-01 00:00:00

  • Follow-up after focal therapy of the prostate with high intensity focused ultrasound (HIFU) using contrast enhanced ultrasound (CEUS) in combination with MRI image fusion.

    abstract:INTRODUCTION:Focal therapy (FT) of the prostate for low risk prostate cancer (PCa) is an alternative to traditional definite treatment options like external beam radiotherapy or radical prostatectomy. However, follow up after FT is still challenging and is subject to current studies. Significance of imaging after FT su...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-199222

    authors: Apfelbeck M,Chaloupka M,Schlenker B,Stief CG,Clevert DA

    更新日期:2019-01-01 00:00:00

  • Effects of cardiotonic pill on RBC rheologic abnormalities in HFD-induced mice and LPL deficient mice.

    abstract::The lipoprotein lipase deficient (LPL-/-) mice and high fat-diet (HFD) induced hypertriglyceridemic mice were used to investigate the effects of cardiotonic pill (CP) on RBC rheologic abnormalities. Mice were randomly divided into the following five groups: the control group; the untreated HFD group; the untreated LPL...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Wang XW,Guo J,Wang XF,Chen XP,Wen ZY

    更新日期:2008-01-01 00:00:00

  • Shear resistance of human umbilical endothelial cells on different materials covered with or without extracellular matrix: controlled in-vitro study.

    abstract::A variety of medical grade polymeric materials are used in tissue engineering and biomedical technology. Dense non-porous polymeric foils were used as substrates for endothelial cell layers. Half a the test samples (polymers and control materials) were seeded with bovine corneal endothelial cells (BCEC) which more or ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2009-1230

    authors: Hoepken S,Fuhrmann R,Jung F,Franke RP

    更新日期:2009-01-01 00:00:00

  • Altitude training induced alterations in erythrocyte rheological properties: a controlled comparison study in rats.

    abstract::Altitude training is frequently used by athletes to improve sea-level performance. However, the objective benefits of altitude training are controversial. This study aimed to investigate the possible alterations in hemorheological parameters in response to altitude training. Sprague Dawley rats, were divided into 6 gr...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-131711

    authors: Bor-Kucukatay M,Colak R,Erken G,Kilic-Toprak E,Kucukatay V

    更新日期:2014-01-01 00:00:00

  • Hemorheological disturbances in cerebrovascular diseases.

    abstract::The aim of the study was to evaluate the possible relationship of the hemorheological disturbances with the clinical symptoms and some risk factors (RF) for cerebrovascular diseases (CVD). The study included 68 patients with CVD, 29 with transient ischemic attacks (TIA) and 39 with chronic unilateral cerebral infarcti...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Velcheva I,Antonova N,Titianova E,Damianov P,Dimitrov N,Dimitrova V

    更新日期:2008-01-01 00:00:00

  • The peripapillary retinal capillary density is highly correlated with its nerve fibre layer in normal population.

    abstract:PURPOSE:To explore the peripapillary capillary density distribution and its correlation with nerve fibre layer in superficial and deep retinal layers of healthy Chinese. METHODS:Images of superficial and deep retinal capillary networks were obtained by optical coherence tomography angiography (OCTA) using a CIRRUS TM ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-180453

    authors: Ding X,Lu L,Yang J,Chen Y,Ma J

    更新日期:2020-01-01 00:00:00

  • Effects of exercise training on blood rheology: a meta-analysis.

    abstract::Regular exercise has been reported to improve blood rheology, but all the studies investigating this issue included a reduced number of subjects, and thus it was logic to perform a meta-analysis of them in order to better characterize this physiological effect. Research was handed on Medline from 1950 to 2010. Studies...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,meta分析

    doi:10.3233/CH-2011-1469

    authors: Romain AJ,Brun JF,Varlet-Marie E,Raynaud de Mauverger E

    更新日期:2011-01-01 00:00:00

  • Erythrocyte deformability in morbid obesity before bariatric surgery. Influence of abdominal obesity.

    abstract::Although there are several studies dealing with erythrocyte deformability (ED) in obese patients, research on this topic in morbidly obese subjects is scarce. In these studies ED seems to be decreased, although the cause remains unknown. A case-control study in 76 morbid obese subjects (23 women and 53 men, aged 44 ± ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2010-1357

    authors: Vayá A,Cámara R,Hernádez-Mijares A,Romagnoli M,Solá E,Corella D,Laiz B

    更新日期:2010-01-01 00:00:00

  • Formulation of drug-loaded oligodepsipeptide particles with submicron size.

    abstract::The size of particulate carriers is key to their transport and distribution in biological systems, and needs to be tailored in the higher submicron range to enable follicular uptake for dermal treatment. Oligodepsipeptides are promising nanoparticlulate carrier systems as they can be designed to exhibit enhanced inter...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-200977

    authors: Brunacci N,Wischke C,Naolou T,Patzelt A,Lademann J,Neffe AT,Lendlein A

    更新日期:2020-11-11 00:00:00

  • Effects of Ramipril and Isradipin on hemorheological profiles in patients with arterial hypertension.

    abstract::In this study, the effect of the angiotensin-converting-enzyme inhibitor (ACE inhibitor) Ramipril (5 mg/day) and calcium antagonist Isradipin (5 mg/day) treatment of two groups of hypertensive patients (n = 22 in each of group) was evaluated. The parameters of the hemorheological profile (blood and plasma viscosity, r...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Muravyov AV,Zaitsev LG,Muravyov AA,Yakusevich VV,Sirotkina AM

    更新日期:1998-07-01 00:00:00

  • Protective effect of tetramethylpyrazine and salvianolic acid B on apoptosis of rat cerebral microvascular endothelial cell under high shear stress.

    abstract::Apoptosis induced by high shear stress has been reported for the dysfunction of various vascular endothelial cells. We investigated the protective effects of tetramethylpyrazine (TMP) and salvianolic acid B (SAB) from Chinese medicine on the shear-induced early and late stages of apoptosis in cultured rat cerebral mic...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Li M,Zhao MQ,Kumar Durairajan SS,Xie LX,Zhang HX,Kum WF,Goto S,Liao FL

    更新日期:2008-01-01 00:00:00

  • What is the maximum duration to perform the hemorheological measurement for the human and mammals.

    abstract::The hemorheological performance of mammals and human will change with the time after the blood is withdraw from the subject. The whole blood apparent viscosity, erythrocyte deformability and aggregation of some mammals and human were measured. Our results showed that the hemorheological characteristics of mice, rats, ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Zhang J,Zhang X,Wang N,Fan Y,Ju H,Yang J,Wen J,Qu X

    更新日期:2004-01-01 00:00:00

  • A comparative study of the haemorheology of various breeds of dog.

    abstract::Haemorheological parameters in nine breeds of dog were examined. Whole blood viscosity at both high and low shear rates differed significantly between the breeds with a 50% difference between the highest and lowest viscosity at high shear rate and a 140% difference at low shear rate. Athletic breeds (Greyhounds, Deerh...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Bodey AR,Rampling MW

    更新日期:1998-07-01 00:00:00

  • Thrombomodulin levels in asymptomatic familial hypercholesterolemia.

    abstract::In order to ascertain whether young asymptomatic patients with heterozygous familial hypercholesterolemia (FH) but without clinical signs of atherosclerosis have increased plasma thrombomodulin (TM) levels expressing early endothelial damage, we determined TM in 23 heterozygous FH subjects (aged 28-44 years, x: 32 +/-...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Vayá A,Martínez M,Ballesta A,Martí R,Ortuño C,Aznar J

    更新日期:1999-01-01 00:00:00

  • Aggregability and disaggregability of erythrocytes in women suffering from ovarian cancer: evidence for an increased disaggregation threshold.

    abstract::In order to further characterize the alterations of erythrocyte aggregation described in ovarian cancer, we measured it with laser backscattering in eleven women suffering from ovarian cancer (mean age: 44.7 +/- 3.6, extreme values: 28-61 yr) compared with thirteen matched control women. Blood rheology exhibited a wid...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: El Bouhmadi A,Laffargue F,Brun JF

    更新日期:2000-01-01 00:00:00

  • Interaction of thrombocytes with poly(ether imide): The influence of processing.

    abstract::The processing of polymers for blood contacting devices can have a major influence on surface properties. In this study, we fabricated poly(ether imide) (PEI) membranes and films to investigate the effects of the processing on physicochemical surface properties by atomic force microscopy (AFM), scanning electron micro...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2010-1351

    authors: Braune S,Lange M,Richau K,Lützow K,Weigel T,Jung F,Lendlein A

    更新日期:2010-01-01 00:00:00

  • Effects of haemoglobin levels on the sublingual microcirculation in pregnant women.

    abstract::Anemia in pregnant women is associated with increased maternal and perinatal mortality and represents an important economic burden in many developing countries. Our goal was to evaluate the impact of anemia on the capillary network during pregnancy. Therefore, we compared microcirculatory parameters of anemic pregnant...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-162064

    authors: Sharawy N,Hussein A,Hossny O,Refaa A,Saka A,Mukhtar A,Whynot S,George R,Lehmann C

    更新日期:2016-11-25 00:00:00

  • Value of high-resolution contrast-enhanced ultrasound in detection and characterisation of endoleaks after EVAR.

    abstract:PURPOSE:To compare the value of high-resolution contrast-enhanced ultrasound in the detection and characterisation of endoleaks after EVAR. MATERIAL AND METHODS:In this retrospective study, a cohort of 80 patients underwent both standard examination using a curved array 5 MHz transducer and a second examination using ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-141896

    authors: Zimmermann H,D'Anastasi M,Rjosk-Dendorfer D,Helck A,Meimarakis G,Reiser M,Clevert DA

    更新日期:2014-01-01 00:00:00

  • Red blood cell distribution width and erythrocyte deformability in patients with acute myocardial infarction.

    abstract::Increased RDW has been found to be a marker of adverse outcomes in cardiovascular disease (CVD), although the exact mechanism remains unclear. Recently, several authors have found that higher RDW is associated with decreased erythrocyte deformability, which can impair blood flow through microcirculation, a fact which ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-131751

    authors: Vayá A,Rivera L,de la Espriella R,Sanchez F,Suescun M,Hernandez JL,Fácila L

    更新日期:2015-01-01 00:00:00

  • Changes in the microcirculation at the superficial and deeper levels in lymphoedema: the effects and results of massage, compression, exercise and benzopyrones on these levels during treatment.

    abstract::This review starts with a brief description of the pioneering work done by J.R. Casley-Smith when he looked at the pathophysiological changes that occur, and transport from the blood vessels, through the interstitium to the lymphatics and lymphatic uptake, with the electron microscope. Collaboration with, and further ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Casley-Smith JR

    更新日期:2000-01-01 00:00:00

  • Elevated plasma nitric oxide metabolites in hypertension: synergistic vasodepressor effects of a static magnetic field and nicardipine in spontaneously hypertensive rats.

    abstract::The involvement of plasma nitric oxide metabolites (NO(x)) in hypertension was examined in stroke-resistant spontaneously hypertensive rats during the development of hypertension. Continuous application of a static magnetic field (SMF; a maximum magnetic flux density of 180 millitesla, a peak magnetic gradient of 133 ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Okano H,Ohkubo C

    更新日期:2006-01-01 00:00:00

  • Elevated coronary whole blood viscosity in acute coronary syndrome patients.

    abstract:OBJECTIVES:As most clinical studies measure whole blood viscosity (WBV) from peripheral samples, potential differences in WBV obtained from the coronary arteries are often ignored. This study investigated differences in WBV measured from coronary artery specimens in patients with and without acute coronary syndrome (AC...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-131692

    authors: Lee SR,Jung JM,Jung LY,Lee JH,Lee SH,Rhee KS,Chae JK,Kim WH,Ko JK,Lee DH,Rosenson RS

    更新日期:2013-01-01 00:00:00

  • Importance of methodological standardization for the ektacytometric measures of red blood cell deformability in sickle cell anemia.

    abstract::Red blood cell (RBC) deformability is severely decreased in patients with sickle cell anemia (SCA), which plays a role in the pathophysiology of the disease. However, investigation of RBC deformability from SCA patients demands careful methodological considerations. We assessed RBC deformability by ektacytometry (LORR...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-151979

    authors: Renoux C,Parrow N,Faes C,Joly P,Hardeman M,Tisdale J,Levine M,Garnier N,Bertrand Y,Kebaili K,Cuzzubbo D,Cannas G,Martin C,Connes P

    更新日期:2016-01-01 00:00:00

  • Bioresorbable everolimus-eluting vascular scaffold for patients presenting with non STelevation-acute coronary syndrome: A three-years follow-up1.

    abstract:AIM:To investigate three-year outcomes of patients presenting with nonSTelevation acute coronary syndrome (NSTE-ACS) treated with bioresorbable everolimus-eluting vascular scaffolds (BRS). METHODS AND RESULTS:The study included a total of 488 consecutive patients, enrolled between May 2012 and December 2013 (median ag...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-189101

    authors: Anadol R,Dimitriadis Z,Polimeni A,Wendling F,Gönner S,Ullrich H,Lorenz L,Weissner M,Munzel T,Gori T

    更新日期:2018-01-01 00:00:00

  • Hemorheological changes in ischemia-reperfusion: an overview on our experimental surgical data.

    abstract::Blood vessel occlusions of various origin, depending on the duration and extension, result in tissue damage, causing ischemic or ischemia-reperfusion injuries. Necessary surgical clamping of vessels in vascular-, gastrointestinal or parenchymal organ surgery, flap preparation-transplantation in reconstructive surgery,...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,评审

    doi:10.3233/CH-131648

    authors: Nemeth N,Furka I,Miko I

    更新日期:2014-01-01 00:00:00

  • Influence of shear stress on erythrocyte aggregation.

    abstract::Shear stress is known to induce platelet activation and aggregation. The red blood cell (RBC) aggregation test requires the application of shear stress for the cells to disaggregate for initialization. We tested the hypothesis that applying shear stress may activate platelets, which can influence RBC aggregation. The ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-151969

    authors: Kim JH,Lee H,Lee BK,Shin S

    更新日期:2016-01-01 00:00:00

  • Non-invasive contrast enhanced ultrasound for quantitative assessment of tumor microcirculation. Contrast mixed mode examination vs. only contrast enhanced ultrasound examination.

    abstract:PURPOSE:To evaluate the different ultrasound techniques for quantification of contrast enhanced ultrasound (CEUS) in an experimental rat prostate carcinoma model. METHOD AND MATERIALS:Prostate carcinoma (MLLB-2) cells were subcutaneously injected into the right flank of male rat (Charles River, Sulzfeld, Germany, 180 ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2010-1341

    authors: Paprottka PM,Cyran CC,Zengel P,von Einem J,Wintersperger B,Nikolaou K,Reiser MF,Clevert DA

    更新日期:2010-01-01 00:00:00

  • Contrast-enhanced ultrasonography (CEUS) using early dynamic in microcirculation for localization of pathological parathyroid glands: first-line or complimentary diagnostic modality?

    abstract:BACKGROUND:Contrast-enhanced ultrasonography (CEUS) represents a new diagnostic tool to localize pathological parathyroid glands. The aim of this study was to differentiate the capability of CEUS as first-line or complimentary modality for the detection of hyperfunctioning parathyroid glands. METHODS:Sixty patients wi...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1459

    authors: Hornung M,Jung EM,Stroszczynski C,Schlitt HJ,Agha A

    更新日期:2011-01-01 00:00:00

  • Timing of clopidogrel loading dose on peripheral blood endothelial progenitor cells, SDF-1α and neointimal hyperplasia in carotid stenting.

    abstract:BACKGROUND:Carotid stenting stimulates intimal proliferation through platelet and stem cell activation. OBJECTIVE:The aim of this study is to evaluate whether the administration before or after carotid stenting of clopidogrel loading dose may play a role on circulating endothelial progenitor cells, stromal cell-derive...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/CH-180429

    authors: Di Stolfo G,Mastroianno S,Ruggieri M,Fontana A,Marinucci R,Copetti M,Minervini MM,Savino L,Mastroianno M,Savino M,Pacilli MA,Di Mauro L,Potenza DR,Cascavilla N,Paroni G,Russo A

    更新日期:2019-01-01 00:00:00