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Psychological adjustment to familial genetic risk assessment: differences in two longitudinal samples.

Abstract：

:Heritable cancer risk assessment is an increasingly common method of deriving valuable information relevant to deciding on appropriate screening regimens and preventive treatments. Assessments of heritable risk typically include familial-genetic evaluation, where analyses relate family pedigree to cancer risk, and DNA testing, where analyses indicate genetic mutations associated with cancer risk (e.g., BRCA1/BRCA2 mutations) or their absence. In this paper we report on the psychological responses of women given familial-genetic evaluations for ovarian cancer risk. The baseline and 6 to 12 follow-up assessments of an initial clinic-attending cohort of 65 women are compared with the baseline and 9 to 12 follow-up assessments of a second clinic-attending cohort of 60 women. Sizeable differences were found in the prevalence of clinically significant depression in these two physician or self-referred populations, as assessed by the Center for Epidemiological Studies Depression scale and in the mean scores. Hypotheses accounting for these differences are discussed.

journal_name

Patient Educ Couns

journal_title

Patient education and counseling

authors

Ritvo P,Robinson G,Irvine J,Brown L,Matthew A,Murphy KJ,Stewart DS,Styra R,Wang C,Mullen M,Cole D,Rosen B

doi

10.1016/s0738-3991(99)00082-8

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

163-72

issue

2

eissn

0738-3991

issn

1873-5134

pii

S0738-3991(99)00082-8

journal_volume

40

pub_type

杂志文章

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