Postpemphigus acanthomata: a sign of clinical activity?

Abstract:

BACKGROUND:Pemphigus is a group of vesiculobullous disorders in which the blisters usually heal with hyper or hypopigmentation. The appearance of acanthomata at sites of previous blisters has been noted in some cases. METHODS:All cases of pemphigus admitted to the Madras Medical College hospitals during a 2-year period from March 1993 to March 1995 were taken into the study and screened for the presence of acanthomata. RESULTS:Fifty-two cases of pemphigus were identified, 47 of pemphigus vulgaris and five of pemphigus foliaceus; and of these 13 developed acanthomata when the blisters healed. Ten of these cases were of pemphigus vulgaris and three were of pemphigus foliaceus; biopsy of these lesions showed hyperkeratosis, acanthosis, papillomatosis, and intraepidermal clefting. Immunofluorescence carried out in two of these acanthomata also showed intercellular fluorescence. CONCLUSIONS:The occurrence of acanthomata in healed lesions of pemphigus is not uncommon; because histopathologic and immunofluorescence evidence of disease activity is present, cases of this sort require careful follow-up.

journal_name

Int J Dermatol

authors

Yesudian PD,Krishnan SG,Jayaraman M,Janaki VR,Yesudian P

doi

10.1046/j.1365-4362.1997.00092.x

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

194-6

issue

3

eissn

0011-9059

issn

1365-4632

journal_volume

36

pub_type

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