Abstract:
:The immune system is composed of single cells, and its function is entirely dependent on the capacity of these cells to traffic, localize within tissues, and interact with each other in a precisely coordinated fashion. There is growing evidence that the large families of chemokines and chemokine receptors provide a flexible code for regulating cell traffic and positioning in both homeostatic and inflammatory conditions. The regulation of chemokine receptor expression during development and following cell activation explains the complex migratory pathways taken by dendritic cells, T and B lymphocytes, providing new insights into the mechanisms that control priming, effector function, and memory responses.
journal_name
Annu Rev Immunoljournal_title
Annual review of immunologyauthors
Sallusto F,Mackay CR,Lanzavecchia Adoi
10.1146/annurev.immunol.18.1.593subject
Has Abstractpub_date
2000-01-01 00:00:00pages
593-620eissn
0732-0582issn
1545-3278pii
18/1/593journal_volume
18pub_type
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abstract::This review summarizes the general parameters of cell- and antibody-mediated immune protection and the basic mechanisms responsible for what we call immunological memory. From this basis, the various successes and difficulties of vaccines are evaluated with respect to the role of antigen in maintaining protective immu...
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abstract::CD45 is one of the most abundant leukocyte cell surface glycoproteins and is expressed exclusively upon cells of the hematopoietic system. Different isoforms of CD45 are generated by alternative splicing and are expressed in cell type-specific patterns on functional subpopulations of lymphocytes. In a major advance, C...
journal_title:Annual review of immunology
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:1998-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1995-01-01 00:00:00
abstract::T and B cells share a common somatic gene rearrangement mechanism for assembling the genes that code for their antigen receptors; they also have developmental pathways with many parallels. Shared usage of basic helix-loop-helix E proteins as transcriptional drivers underlies these common features. However, the transcr...
journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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abstract::T helper lymphocytes can be divided into two distinct subsets of effector cells based on their functional capabilities and the profile of cytokines they produce. The Th1 subset of CD4+ T cells secretes cytokines usually associated with inflammation, such as IFN-gamma and TNF and induces cell-mediated immune responses....
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abstract::A host has two methods to defend against pathogens: It can clear the pathogens or reduce their impact on health in other ways. The first, resistance, is well studied. Study of the second, which ecologists call tolerance, is in its infancy. Tolerance measures the dose response curve of a host's health in reaction to a ...
journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
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更新日期:2012-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 传,历史文章,杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:2019-04-26 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
abstract::The epithelial architecture of the thymus fosters growth, differentiation, and T cell receptor repertoire selection of large numbers of immature T cells that continuously feed the mature peripheral T cell pool. Failure to build or to maintain a proper thymus structure can lead to defects ranging from immunodeficiency ...
journal_title:Annual review of immunology
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更新日期:2008-01-01 00:00:00
abstract::The tripartite subdivision of lymphocytes into B cells, alphabeta T cells, and gammadelta cells has been conserved seemingly since the emergence of jawed vertebrates, more than 450 million years ago. Yet, while we understand much about B cells and alphabeta T cells, we lack a compelling explanation for the evolutionar...
journal_title:Annual review of immunology
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更新日期:2000-01-01 00:00:00
abstract::Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that many proinflammatory cytokines such as TNF alpha, IL-1, IL-6, GM-CSF, and chemokines such as IL-8 are abundant in all patients regardless of therapy. This is compensated to some degree by the increased production of anti-inflammatory cy...
journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
abstract::The discovery of new functions for the original B7 family members, together with the identification of additional B7 and CD28 family members, have revealed new ways in which the B7:CD28 family regulates T cell activation and tolerance. B7-1/B7-2:CD28 interactions not only promote initial T cell activation but also reg...
journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
abstract::The Notch pathway is gaining increasing recognition as a key regulator of developmental choices, differentiation, and function throughout the hematolymphoid system. Notch controls the generation of hematopoietic stem cells during embryonic development and may affect their subsequent homeostasis. Commitment to the T ce...
journal_title:Annual review of immunology
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更新日期:2005-01-01 00:00:00