Curculin, a sweet-tasting and taste-modifying protein, is a non-functional mannose-binding lectin.

Abstract:

:A three-dimensional model of curculin, a sweet-tasting and taste-modifying protein from the fruits of Curculigo latifolia, was built from the X-ray coordinates of GNA, a mannose-binding lectin from snowdrop (Galanthus nivalis). The three mannose-binding sites present in GNA were found in curculin but are devoid of mannose-binding activity as shown by docking experiments performed with mannose. Some regions well exposed on the surface of the three-dimensional model of curculin could act as epitopes responsible for the sweet-tasting properties of this protein.

journal_name

Plant Mol Biol

journal_title

Plant molecular biology

authors

Barre A,Van Damme EJ,Peumans WJ,Rougé P

doi

10.1023/a:1005704616565

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

691-8

issue

4

eissn

0167-4412

issn

1573-5028

journal_volume

33

pub_type

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