Abstract:
PURPOSE:To evaluate the epidemiology, possible etiologic factors, complications encountered, and treatment administered to a group of patients with ocular involvement in the erythema multiforme/Stevens-Johnson syndrome/toxic epidermal necrolysis disease spectrum who were seen at two large tertiary referral centers over a 34-year period. METHODS:Hospital records from 1960 to 1994 at the Massachusetts General Hospital and Shriners Hospital for Crippled Children were reviewed for patients with erythema multiforme, Stevens-Johnson syndrome, or toxic epidermal necrolysis. Only patients fulfilling specific clinical diagnostic criteria and those who received a diagnosis by a dermatologist were included in the review. RESULTS:A total of 366 patients with erythema multiforme, Stevens-Johnson syndrome, or toxic epidermal necrolysis were identified. Drugs were the most commonly identified etiologic factor in all three conditions: sulfonamides were the most frequently identified agents. Eighty-nine patients (24%) had ocular manifestations at the time of their acute hospital stay. Ocular involvement was seen in 9% of patients with erythema multiforme, in 69% with Stevens-Johnson syndrome, and in 50% with toxic epidermal necrolysis. The ocular problems were more severe in patients with both Stevens-Johnson syndrome and toxic epidermal necrolysis. There was no significant difference between the number of patients who were treated with systemic steroids and those who were not (P = 0.42). CONCLUSIONS:The erythema multiforme/Stevens-Johnson syndrome/toxic epidermal necrolysis disease spectrum remains an important cause of severe visual loss in a significant number of patients. Systemic steroids used during the acute phase of the disease appear to have no effect on the development of ocular manifestations. Studies on the acute immunopathogenic mechanisms occurring in these disease are warranted if more effective therapies are to be found.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Power WJ,Ghoraishi M,Merayo-Lloves J,Neves RA,Foster CSdoi
10.1016/s0161-6420(95)30811-1subject
Has Abstractpub_date
1995-11-01 00:00:00pages
1669-76issue
11eissn
0161-6420issn
1549-4713pii
S0161-6420(95)30811-1journal_volume
102pub_type
杂志文章,多中心研究相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:To compare rates of peripheral retinal changes in Age-Related Eye Disease Study 2 (AREDS2) participants with at least intermediate age-related macular degeneration (AMD) with control subjects without intermediate age-related changes (large drusen). DESIGN:Cross-sectional evaluation of clinic-based patients enr...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2016.12.004
更新日期:2017-04-01 00:00:00
abstract::The authors report seven patients in whom the acute retinal necrosis (ARN) syndrome developed shortly after cutaneous varicella zoster infection. The length of time between the skin infection and ARN varied from 5 days to 3 months. Both eyes were affected in one of seven cases. The ophthalmic branch of cranial nerve V...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33405-0
更新日期:1987-06-01 00:00:00
abstract::Vitreous incarceration in the cataract wound may contribute to development of aphakic cystoid macular edema, vitreoretinal traction and retinal detachment, and corneal decompensation. Thirty-one eyes in which vitreous was incarcerated in the cataract wound were examined postmortem and the corneal, anterior segment, an...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33758-8
更新日期:1986-02-01 00:00:00
abstract:PURPOSE:To analyze visual acuity (VA) outcomes before and after preplanned treatment regimen change in the VIEW studies at week 52 (W52). DESIGN:Multiple post hoc analyses for retrospectively defined subgroups in 2 multicenter, multinational, double-masked trials. PARTICIPANTS:Two thousand four hundred fifty-seven ne...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2015.08.014
更新日期:2015-12-01 00:00:00
abstract::Cytomegalovirus (CMV) retinitis is the major cause of visual loss in acquired immune deficiency syndrome (AIDS). Thirty-one patients with active CMV retinitis were treated with the new antiviral drug, Foscarnet (trisodium phosphonoformate). After a 3-week course of induction therapy, the retinitis improved in 29 of 31...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32824-7
更新日期:1989-06-01 00:00:00
abstract:PURPOSE:Novel anterior segment optical coherence tomography (ASOCT) parameters associated with angle closure include anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and iris curvature (I-curv). We aimed to investigate ch...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2012.01.019
更新日期:2012-07-01 00:00:00
abstract::Up to now, the attention of ophthalmic surgeons has been focused mainly on the clinical results of epikeratophakia, demonstrating its safety, relative predictability, and capability of correcting a wide range of refractive errors. However, no prospective study has ever been undertaken to evaluate the influence of epik...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32585-x
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the visual and refractive outcome of corneal transplant surgery, cataract extraction, and intraocular lens (IOL) implantation in children with traumatic corneal laceration and cataract. DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Five patients, 7 years of age or younger, who u...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00524-8
更新日期:2001-02-01 00:00:00
abstract:PURPOSE:The ability to detect reticular pseudodrusen (RPD)/subretinal drusenoid deposits (SDDs) using 12×12-mm widefield en face swept-source optical coherence tomography (SS-OCT) imaging was compared with conventional multimodal imaging (color, fundus autofluorescence (FAF), and infrared reflectance [IR] imaging) in e...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.10.009
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:This study aimed to establish a practical diagnostic test for choroideremia (CHM) and to show its application in a family with the clinical diagnosis of choroideremia. DESIGN:Case series. PARTICIPANTS:Sixteen males from 13 families with clinically documented CHM and unaffected normal males were enrolled in ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)99031-5
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To determine the outcome of pediatric dacryocystorhinostomy (DCR) for large mucoceles or for primary nasolacrimal duct obstruction unresponsive to multiple probings. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:One hundred thirty-four external dacryocystorhinostomies were performed in 121 c...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00699-6
更新日期:2001-09-01 00:00:00
abstract:PURPOSE:To apply lessons learned in the treatment of systemic hypertension to the problem of nonadherence in glaucoma medical therapy. CLINICAL RELEVANCE:Although physicians recognize that nonadherence with glaucoma medication is a problem, most lack the skill set to identify nonadherent patients, to identify the caus...
journal_title:Ophthalmology
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.ophtha.2009.06.022
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To determine the ophthalmologic findings, especially the nature of retinal vascular changes, and their clinical significance in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a disease that causes migraine, recurrent strokes, and finally subcortical vascu...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.03.030
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To identify any mutation of the UbiA prenyltransferase domain-containing protein 1 (UBIAD1) gene in Japanese patients with Schnyder's crystalline corneal dystrophy (SCCD) and to investigate in vivo microstructural phenotype and genotype correlations using laser scanning confocal microscopy (Heidelberg Retina ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.12.042
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To illustrate some management problems with pigmented iris tumors. METHODS:This is a retrospective analysis of 234 iris tumors managed by one of the authors. Five patients were selected whose clinical course and pathologic data illustrate diagnostic problems that can occur with these tumors. RESULTS:In the pa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30708-2
更新日期:1996-02-01 00:00:00
abstract::Bimedial rectus recession with measurement from the limbus was combined with conjuctival recession 85 children undergoing surgery for esotropia. Using this augmented recession technique, the prism diopters of correction per millimeter of surgery done were 4.8 compared with 3.2 found in 56 control patients. Postoperati...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(78)35647-5
更新日期:1978-05-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of a combination of 5-fluorouracil (5FU) and low-molecular-weight heparin (LMWH) in the treatment of unselected rhegmatogenous retinal detachment (RRD) undergoing primary vitrectomy. DESIGN:Double-masked, prospective, randomized, placebo-controlled clinical trial. PARTICIPANTS:Six ...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2006.08.042
更新日期:2007-04-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate 24-hour intraocular pressure (IOP) control in patients with moderate to severe open-angle glaucoma treated by trabeculectomy and mitomycin C versus maximum tolerated medical therapy. DESIGN:Prospective observational study. PARTICIPANTS:Thirty surgical patients and 30 ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2006.01.029
更新日期:2006-05-01 00:00:00
abstract::A temporary apposition of retina and choroid has been created during retinal detachment surgery by injection of sodium hyaluronate into the suprachoroidal space in 14 patients. The iatrogenic choroidal detachment lasts at least seven to ten days, allowing adequate time for retinopexy to permanently seal the retinal ho...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33553-x
更新日期:1986-11-01 00:00:00
abstract:PURPOSE:To describe the heritability and sibling risk for angle closure. DESIGN:Prospective clinical study. PARTICIPANTS:Probands with primary angle closure (PAC) and primary angle-closure glaucoma (PACG) and their first-degree relatives. METHODS:One hundred probands with PAC and PACG and their first-degree relative...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.06.043
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To describe the incidence of and risk factors for visual acuity (VA) loss and ocular complications in patients with juvenile idiopathic arthritis (JIA)-associated uveitis. DESIGN:Multicenter retrospective cohort study. PARTICIPANTS:A total of 327 patients (596 affected eyes) with JIA-associated uveitis manage...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2012.07.052
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To evaluate corneal surface regularity and asymmetry, corneal thickness, barrier function, and contrast sensitivity after experimental removal of the precorneal tear layer. DESIGN:Prospective, clinic-based, nonrandomized (self-controlled) comparative trial. PARTICIPANTS:Six eyes of six healthy volunteers (thr...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00273-6
更新日期:2000-09-01 00:00:00
abstract:PURPOSE:To illustrate the role of surgical removal of iris nodules (granulomas) in the management of sarcoid uveitis. STUDY DESIGN:Two interventional case reports. METHODS:The authors describe the clinical course of two 10-year-old males with long-standing granulomatous uveitis refractory to medical antiinflammatory ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00601-7
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To determine the long-term motor and sensory results after early surgical correction of patients with congenital esotropia. DESIGN:Noncomparative interventional case series. PARTICIPANTS:Ten infants with congenital esotropia. INTERVENTION:Patients had bimedial rectus recession between 83 and 159 days of ag...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90337-8
更新日期:1999-09-01 00:00:00
abstract:PURPOSE:To test if improving optical coherence tomography (OCT) resolution and scanning speed improves the visualization of glaucomatous structural changes as compared with conventional OCT. DESIGN:Prospective observational case series. PARTICIPANTS:Healthy and glaucomatous subjects in various stages of disease. MET...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.06.038
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:To compare the impact of first eye versus second eye cataract surgery on visual function and quality of life. DESIGN:Cohort study. PARTICIPANTS:A total of 328 patients undergoing separate first eye and second eye phacoemulsification cataract surgeries at 5 veterans affairs centers in the United States. Patien...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2017.04.014
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To compare effective phacoemulsification time after femtosecond laser pretreatment with conventional phacoemulsification and the associated effect on visual outcomes and endothelial cell loss. DESIGN:Prospective, consecutive, single-surgeon case-control study. CONTROLS:Controls underwent phacoemulsification...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.11.045
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Branch retinal vein occlusion (BRVO) is occasionally complicated by two types of retinal breaks (retinal holes without vitreous traction or retinal traction tears) that may lead to a rhegmatogenous retinal detachment (RRD). The authors describe surgical results of vitrectomy for RRD after BRVO and investigat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30366-2
更新日期:1997-01-01 00:00:00
abstract::The zonules of 27 postmortem eyes were studied grossly using a histologic staining technique that allowed easy visualization of the zonules. Large disinsertions of the zonules were present in 5 of the 20 eyes that had undergone extracapsular cataract extraction (ECCE). ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33423-2
更新日期:1987-05-01 00:00:00
abstract:PURPOSE:To identify factors that influence the outcome of patients with severe infectious corneal ulcers. METHOD:A retrospective review was performed of the hospital records of all such patients admitted to the Doheny Eye Hospital during a 30 month period. Outcome variables examined were change in visual acuity, durat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30771-3
更新日期:1995-12-01 00:00:00