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Early prediction of long-term survival and the timing of liver transplantation after the Kasai operation.

Abstract：

BACKGROUND/PURPOSE:The aim of this study was to determine early prognostic indicators for the prediction of long-term survival rate and timing of the liver transplantation after the Kasai operation. METHODS:A retrospective chart study was performed on 142 patients with biliary atresia (BA). The patients were divided in a success and a failure group, according to whether the patients serum bilirubin levels returned to normal (less than 1.0 mg/dL) within 3 months. The differences in survival rates and performance status between the 2 groups were analyzed statistically. RESULTS:The difference in cumulative survival rate between the 2 groups was striking. When the current status of the 40 patients who had survived for over 12 years was compared, 16 patients (53.3%) from the success group and 1 (9.1%) from the failure group had normal bilirubin levels, normal growth, no esophageal varix, and no hypersplenism. From the Kaplan-Meier survival curve, 3 types of deterioration were identified. Type 1 was death within 3 years. In type 2, deterioration occurred from 4 to 13 years. Type 3 was defined as unexpected deterioration in the success group, and its incidence was extremely low. CONCLUSIONS:Serum bilirubin level at 3 months after the Kasai operation can be used to predict long-term survival and the time when the onset of liver failure is likely to occur.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Ohhama Y,Shinkai M,Fujita S,Nishi T,Yamamoto H

doi

10.1053/jpsu.2000.7765

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

1031-4

issue

7

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(00)08444-X

journal_volume

35

pub_type

杂志文章

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