Abstract:
:Induction of virus-specific T-cell responses in mucosal as well as systemic compartments of the immune system is likely to be a critical feature of an effective AIDS vaccine. We investigated whether virus-specific CD8(+) lymphocytes induced in rhesus macaques by immunization with attenuated simian immunodeficiency virus (SIV), an approach that is highly effective in eliciting protection against mucosal challenge, express the mucosa-homing receptor alpha4beta7 and traffic to the intestinal mucosa. SIV-specific CD8(+) T cells expressing alpha4beta7 were detected in peripheral blood and intestine of macaques infected with attenuated SIV. In contrast, virus-specific T cells in blood of animals immunized cutaneously by a combined DNA-modified vaccinia virus Ankara regimen did not express alpha4beta7. These results demonstrate the selective induction of SIV-specific CD8(+) T lymphocytes expressing alpha4beta7 by a vaccine approach that replicates in mucosal tissue and suggest that induction of virus-specific lymphocytes that are able to home to mucosal sites may be an important characteristic of a successful AIDS vaccine.
journal_name
J Viroljournal_title
Journal of virologyauthors
Cromwell MA,Veazey RS,Altman JD,Mansfield KG,Glickman R,Allen TM,Watkins DI,Lackner AA,Johnson RPdoi
10.1128/jvi.74.18.8762-8766.2000subject
Has Abstractpub_date
2000-09-01 00:00:00pages
8762-6issue
18eissn
0022-538Xissn
1098-5514journal_volume
74pub_type
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