Antineoplastic and cytogenetic effects of complexes of Pd (II) with 4N-substituted derivatives of 2-acetyl-pyridine-thiosemicarbazone.

abstract：:Angiogenesis is essential for tumour growth. Mostly hypervasculariced renal cell carcinoma (RCC) usually express angiogenic factors, e.g. basic fibroblast factor (bFGF), vascular endothelial growth factor, and angiogenin (ag). This study was designed to evaluate the improvement of serological angiogenesis-factors, the...

journal_title：Anticancer research

authors： Wechsel HW,Bichler KH,Feil G,Loeser W,Lahme S,Petri E

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND/AIM:Hepatitis B virus-encoded X protein (HBx) plays a pivotal role in hepatocellular carcinoma (HCC) progression and treatment resistance. Interestingly, our previous study unexpectedly showed that full-length HBx sensitized HCC cells to lapatinib by up-regulating erb-b2 receptor tyrosine kinase 3 (ERBB3). W...

journal_title：Anticancer research

authors： Chen JY,Huang WC,Wei CT,Chien PH,Chen YJ

更新日期：2019-02-01 00:00:00

abstract：:Integrin alpha v-beta 3 is involved in tumor angiogenesis while the clinical significance of beta 3 integrin expression in colorectal cancer and lung metastases. Analysis was performed on 51 colorectal cancer patients (22 with subsequent lung metastasis and 29 without lung metastasis). Fifty-one primary tumors and 22 ...

journal_title：Anticancer research

authors： Sato T,Konishi K,Kimura H,Maeda K,Yabushita K,Tsuji M,Miwa A

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of 5-fluorouracil (5-FU) catabolism. Several studies have demonstrated the clinical importance of DPD in cancer patients, suggesting that the efficacy of 5-FU may be related to DPD activity in tumor tissue. In the present study, DPD activity a...

journal_title：Anticancer research

authors： Inada T,Ogata Y,Kubota T,Tomikawa M,Yamamoto S,Andoh J,Ozawa I,Hishinuma S,Shimizu H,Kotake K

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:In the present study, we examined the relationships between microsatellite status and Ki-67 labeling index, a proliferative marker, in colorectal cancers in order to clarify the common biological profiles of familial and sporadic cases of MSI (microsatellite inability)-positive tumors. PATIENTS AND METHODS:...

journal_title：Anticancer research

authors： Takagi S,Kumagai S,Kinouchi Y,Hiwatashi N,Nagashima F,Takahashi S,Shimosegawa T

更新日期：2002-11-01 00:00:00

abstract：:Urinary gonadotropin peptide (UGP) has been measured in gynecological and urological cancers, but its usefulness in the diagnosis of cancers of digestive organs has not been investigated. In this report, UGP was measured by sandwich enzyme immunoassay in 311 patients, including 166 patients with cancers of digestive o...

journal_title：Anticancer research

authors： Motoo Y,Watanabe H,Yamaguchi Y,Mouri I,Fujii T,Yamakawa O,Satomura Y,Okai T,Sawabu N

更新日期：1996-07-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major clinical obstacle in the treatment of several cancers including hematological malignancies and solid tumors. The ATP-binding cassette transporter B1 (ABCB1) gene and its product, P-glycoprotein (P-gp), is one molecule that is involved in drug resistance. Here we report on the effe...

journal_title：Anticancer research

authors： Onda K,Suzuki R,Tanaka S,Oga H,Oka K,Hirano T

更新日期：2012-10-01 00:00:00

abstract：:The present study was undertaken to evaluate the effect of phagocytosis of killed yeast on the induction of apoptosis in human metastatic breast cancer cells (MCF-7 and ZR-75-1) and non-metastatic breast cancer cells (HCC70). Heat-killed Saccharomyces cerevisiae, baker's and brewer's yeast, was cultured with cancer ce...

journal_title：Anticancer research

authors： Ghoneum M,Gollapudi S

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Ano-genital carcinoma is a polyfactorial and polygenic disease. Certain strains of human papillomavirus (HPV) have been detected in a high percentage of patients. It has been suggested that p53 polymorphisms may be relevant for the interaction with viral proteins that inactivates p53. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Realacci M,Perrone GA,Sale P,Tafani M,Di Vito M,Perrone-Donnorso R,Zotti G,Russo MA

更新日期：2006-07-01 00:00:00

abstract：:As with SV40-transformed BHK cells (1), pretreatment of BHK cells with 1-beta-D-arabinofuranosylcytosine (araC) very markedly enhanced the resistance frequency to N-phosphonoacetyl-L-aspartate (PALA) but only modestly increased the resistance frequency to vincristine (VCR). AraC pretreatment of cells that already had ...

journal_title：Anticancer research

authors： Chen Y,Goz B,Kirkman L

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Giant cell tumor of the bone (GCTB) is a benign or sometimes semi-malignant neoplasm accounting for 5% of all primary bone tumors. This type of tumor has been historically considered as radioresistant, but nowadays radiotherapy (RT) is used in unresectable, recurrent or incompletely resected cases. Since the...

journal_title：Anticancer research

authors： Kriz J,Eich HT,Mücke R,Büntzel J,Müller RP,Bruns F,Seegenschmiedt MH,Gosheger G,Micke O,German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD).

更新日期：2012-05-01 00:00:00

abstract：:Adrenomedullin (AM) is a hypotensive polypeptide that has been shown to stimulate cyclic AMP and intracellular free Ca2+ agents that are known to induce expression of proto-oncogenes, in various cell types. Transforming growth factor-beta 1 (TGF-beta1) is a multifunctional polypeptide that regulates proliferation, dif...

journal_title：Anticancer research

authors： Kane S,Prentice MA,Mariano JM,Cuttitta F,Jakowlew SB

更新日期：2002-05-01 00:00:00

abstract：:Renal Cell Carcinoma (RCC) is characterized by high intratumoral microvascular density (iMVD) and significantly elevated serologic titers of angiogenesis factors, basic fibroblast growth factor (bFGF), vascular endothelial growth factor (vEGF) and angiogenin (Ag). The goal of the present study was to find whether a co...

journal_title：Anticancer research

authors： Wechsel HW,Feil G,Bichler KH,Beiter T,Gleichmann R

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Initial U.S.A. breast cancer screening rates have risen, but not repeat screening, especially among low-income minority populations. Latinas are particularly at-risk of underscreening. Consequently, late-detection is common, with increased risk of dying after diagnosis. Why women with low-income, particularl...

journal_title：Anticancer research

authors： Terán L,Baezconde-Garbanati L,Márquez M,Castellanos E,Belkić K

更新日期：2007-11-01 00:00:00

abstract：AIM:To report our experience on implementation and preliminary results of a decision-making model based on the recommendations of an Interdisciplinary Oncological Care Group developed for the management of colorectal cancer. PATIENTS AND METHODS:The multidisciplinary team identified a reference guideline using apprais...

journal_title：Anticancer research

authors： Genovesi D,Mazzilli L,Trignani M,DI Tommaso M,Nuzzo A,Biondi E,Tinari N,Martino MT,Innocenti P,DI Sebastiano P,Mazzola L,Lanci C,Neri M,Laterza F,Marino M,Ferrini G,Spadaccini A,Filippone A,DI Giandomenico E,Marulli

更新日期：2014-05-01 00:00:00

abstract：:One hundred and eighty-seven patients with a transitional cell bladder cancer were followed by retrospectively for a mean of 9.5 years. Clinical stage (p less than 0.0001), histological grade (p less than 0.0001), papillary (p less than 0.0001), SPF (p less than 0.0001), M/V index (p less than 0.0001), MAI (p less tha...

journal_title：Anticancer research

authors： Lipponen PK,Eskelinen MJ,Kiviranta J,Nordling S

更新日期：1991-03-01 00:00:00

abstract：:The growth inhibitory effect of trimetrexate (TMQ) is maintained in MCF-7 breast cancer but is decreased in Hs 824.T human bone marrow cells by a priming- and non-toxic 5-fluorouracil (5-FU) dose. Incubation of MCF-7 breast cells with 10 microM TMQ alone or in combination with 10 M 5-FU (TMQ 2 h prior to 5-FU [TMQ/5-F...

journal_title：Anticancer research

authors： Bowen D,Johnson DH,Southerland WM,Hughes DE,Hawkins M Jr

更新日期：1999-09-01 00:00:00

abstract：:MOv18, a non-internalizing monoclonal antibody (MAb) with restricted tumor specificity, was conjugated to ricin toxin (RT). According to their ability to bind to galactose residues of Sepharose 6B, the immunoconjugates were fractionated into Bound and Unbound MOv18-RT. The two conjugates could be distinguished by SDS-...

journal_title：Anticancer research

authors： Cogliati T,Brusa P,Canevari S,Caldera M,Mezzanzanica D,Dosio F,Cattel L,Colnaghi MI

更新日期：1991-01-01 00:00:00

abstract：:A pharmacologically relevant modelling was attempted for screening of new molecules potentially active against non-small-cell lung cancers (NSCLCs). It was in this way that we investigated the in vivo chemosensitivity firstly of three human NSCLCs grafted onto nude mice, secondly of their in vitro primocultures, and t...

journal_title：Anticancer research

authors： Kruczynski A,Kiss R

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Axillary dissection is routinely conducted for all patients with sentinel node (SN)-positive breast cancer. Metastasis to non SNs is not often found after axillary dissection in patients with SN-positive breast cancer. Thus, we investigated clinicopathological features, including immune cells in peripheral b...

journal_title：Anticancer research

authors： Ishizuka Y,Horimoto Y,Nakamura M,Arakawa A,Fujita T,Iijima K,Saito M

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND/AIM:Surgical resection for esophageal cancer has remained the gold-standard therapy provided worldwide. Subcarinal lymph-nodes are classified as peri-esophageal nodes and their dissection may be performed during a 2- or 3-stage esophagectomy. The necessity and prognostic value of subcarinal lymphadenectomy i...

journal_title：Anticancer research

authors： Sdralis EK,Davakis S,Syllaios A,Lorenzi B,Kordzadeh A,Athanasiou A,Petousis S,Liakakos T,Charalabopoulos A

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Pemetrexed and erlotinib represent different agents commonly used for the second-line treatment of patients with advanced-stage non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We analyzed data of 137 patients with advanced-stage non-squamous NSCLC treated with pemetrexed or erlotinib in the second ...

journal_title：Anticancer research

authors： Fiala O,Pesek M,Finek J,Svaton M,Minarik M,Benesova L,Bortlicek Z,Kucera R,Topolcan O

更新日期：2016-01-01 00:00:00

abstract：AIM:Brucea javanica was studied to identify nuclear factor kappaB (NF-κB) inhibitors exhibiting reactive oxygen species (ROS) intracellular amplification. MATERIAL AND METHODS:Eight compounds were evaluated for selective cytotoxicity using HT-29, HeLa, and HL-60 cells, and in a NF-κB assay. Active compounds were then ...

journal_title：Anticancer research

authors： Kim JA,Lau EK,Pan L,De Blanco EJ

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the usefulness of reverse transcription-polymerase chain reaction (RT-PCR) for detecting anaplastic lymphoma kinase (ALK) translocations using cytology samples from lung cancer patients. MATERIALS AND METHODS:We analyzed ALK translocations by RT-PCR in cytology samples from lung cancer pati...

journal_title：Anticancer research

authors： Nakamichi S,Seike M,Miyanaga A,Chiba M,Matsuda K,Kobayashi K,Takahashi A,Takeuchi S,Minegishi Y,Kubota K,Gemma A

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:CD98 expression is high in various human neoplasms. However, the relationship of CD98 expression with the clinicopathological factors of gastric cancer (GC) remains unclear. This study examined CD98 expression and its clinicopathological impact on GC. PATIENTS AND METHODS:Three hundred and thirty-one patien...

journal_title：Anticancer research

authors： Satoh T,Kaira K,Takahashi K,Takahashi N,Kanai Y,Asao T,Horiguchi J,Oyama T

更新日期：2017-02-01 00:00:00

abstract：:In the present study, we have investigated the effect of cytotropic heterogeneous molecular lipid (CHML), a new anticancer agent, on growth suppression in a variety of human tumor cell lines. At a non-toxic concentration (a range from 25 micrograms/ml to 100 micrograms/ml), CHML has shown to strongly inhibit tumor cel...

journal_title：Anticancer research

authors： Zhan Q,Xu Z

更新日期：1999-07-01 00:00:00

abstract：:Germ line point mutations in the RET proto-oncogene have been implicated in four inherited disorders: multiple endocrine neoplasia 2A (MEN 2A) and 2B (MEN 2B); familial medullary thyroid carcinoma (FMTC); and Hirschprung's disease, a congenital lack of enteric plexus neurons. Oncogenically activated RET has also been ...

journal_title：Anticancer research

authors： Alemi M,Lucas SD,Sällström JF,Akerström G,Wilander E

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the efficacy of a combination of gemcitabine and sirolimus in a mouse model of invasive bladder cancer. MATERIALS AND METHODS:Gemcitabine (50 mg/kg) and sirolimus (1.5 mg/kg) were administered to animals previously exposed to N-butyl-N-4(hydroxybutyl)nitrosamine in...

journal_title：Anticancer research

authors： Vasconcelos-Nóbrega C,Colaço A,Santos L,Vala H,Palomino LF,Lopes C,Oliveira PA

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND/AIM:Reportedly, hypertension tends to be associated with response to bevacizumab therapy, because bevacizumab suppresses vascular nitric oxide production. In this study we examined the predictive value of nitric oxide in bevacizumab-treated non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:F...

journal_title：Anticancer research

authors： Muto S,Takagi H,Owada Y,Inoue T,Watanabe Y,Yamaura T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

更新日期：2017-06-01 00:00:00

abstract：:Bcl-2 oncoprotein, a member of a new category of oncogenes associated with the regulation of programmed cell death (apoptosis), has been considered to be involved in biological processes such as tumorigenesis and tumor development. To determine the role of bcl-2 oncoprotein in lung cancer, we preliminarily examined th...

journal_title：Anticancer research

authors： Higashiyama M,Doi O,Kodama K,Yokouchi H,Tateishi R

更新日期：1995-03-01 00:00:00