Abstract:
BACKGROUND:To determinate the bactericidal activity of vancomycin, rifampicin, cefotaxime, ceftriaxone and their double and triple combinations against penicillin and third generation cephalosporin-resistant. Streptococcus pneumoniae strain. METHODS:A study of the bactericidal activity of antibiotics alone and in combination was performed by killing-curves with fixed concentration of 2 micrograms/ml, equivalent to 1 < MIC for cefotaxime and ceftriaxone, to 8 x MIC for vancomycin and to 32 < MIC for rifampin. RESULTS:Vancomycin was the only antibiotic with bactericidal effect at 6 hours. Cefotaxime had bactericidal effect at 12 hours. Rifampin had no bactericidal effect. The association of vancomycin plus third generation cephalosporins (cefotaxime and ceftriaxone) showed indifferent effect. Rifampin decreased the bactericidal activity of vancomycin at 12 hours, when both were studied in combination, and it demonstrated antagonistic effect in the double and triple combination in which rifampicin was included. CONCLUSIONS:All associations of vancomycin plus third generation cephalosporins were bactericidal effects, but they did no show synergistic effects against penicillin- and third generation cephalosporin S. pneumoniae strain 2349. All combinations with rifampin showed decreased bactericidal activity or antagonistic effects. However, these results may be interpreted with caution because the in vivo experience of an experimental meningitis model in rabbits showed that the associations of vancomycin plus rifampin and vancomycin plus cefotaxime and rifampin were effective combinations. More in vivo and in vitro comparative studies are needed to demonstrate the reliability of in vitro results.
journal_name
Enferm Infecc Microbiol Clinjournal_title
Enfermedades infecciosas y microbiologia clinicaauthors
Tubau F,Liñares J,Ardanuy C,Martínez-Lacasa J,Fernández A,Cabellos C,Fernández-Viladrich P,Martín Rsubject
Has Abstractpub_date
1996-12-01 00:00:00pages
590-5issue
10eissn
0213-005Xissn
1578-1852journal_volume
14pub_type
杂志文章abstract:INTRODUCTION:In Venezuela, there have been some reports of carbapenemase KPC-producing Klebsiella pneumoniae. Nevertheless, since the first report in 2008, only a few studies have been done on their molecular epidemiology in this country. METHODS:The aims of this study were to detect extended-spectrum betalactamase (E...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2017.12.004
更新日期:2019-02-01 00:00:00
abstract::The External Quality Control Program of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) includes controls for bacteriology, serology, mycology, parasitology, mycobacteria, virology and molecular microbiology. This article presents the most important conclusions and lessons drawn from the 2...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type:
doi:
更新日期:2008-11-01 00:00:00
abstract::Enfuvirtide is a high-cost, parenterally administered drug commonly used in late phases of HIV infection, when its efficacy may be compromised. To optimize enfuvirtide use, consensus recommendations for this purpose have been formulated by 247 physicians attending patients with HIV infection in Spain. A literature rev...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 共识发展会议,杂志文章,评审
doi:10.1157/13098573
更新日期:2007-02-01 00:00:00
abstract::Quinolone resistance is caused mainly by chromosomal mutations in gram negative bacteria. In 1998, plasmid-mediated resistance to quinolones in clinical isolates was first reported in a Klebsiella pneumoniae strain. Locus qnr (quinolone resistance) was responsible of the quinolone resistance in this plasmid. qnr codes...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
doi:10.1157/13070406
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The analysis of the immune response to rotavirus infection and the characterization of the viral antigens recognized by specific antibodies are of great concern in evaluating the protection against rotavirus. MATERIAL AND METHODS:The levels of rotavirus-specific fecal (sIgA) and serum antibodies (IgM, IgG a...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:To update antiretroviral recommendations in antiretroviral therapy (ART) in HIV-infected children and adolescents. METHODS:Theses guidelines have been formulated by a panel of members of the Plan Nacional sobre el SIDA (PNS) and the Asociacion Espanola de Pediatria (AEP) by reviewing the current available ev...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 共识发展会议,杂志文章,评审
doi:10.1157/13074970
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:China is the second high tuberculosis (TB) burden country in the world. This article was to determinate the molecular characteristic of drug resistance Mycobacterium tuberculosis (DRTB) strains from extra pulmonary tuberculosis (EPTB). METHODS:The medical records of patients with EPTB were reviewed and coll...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2020.04.007
更新日期:2020-06-27 00:00:00
abstract:UNLABELLED:The role of influenza viruses in severe acute respiratory infection (SARI) in Intensive Care Units (ICU) remains unknown. The post-pandemic influenza A(H1N1)pdm09 period, in particular, has been poorly studied. OBJECTIVE:To identify influenza SARI patients in ICU, to assess the usefulness of the symptoms of...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2015.04.004
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Staphylococcus aureus is the main pathogen causing nosocomial infections. Health professionals, including medical students, could be a source of transmission. The aims of the study were to determine the rate of nasal carriage of S.aureus susceptible and resistant to methicillin (MRSA) and evaluate the knowle...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2012.12.005
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:This review summarizes the different species of dermatophytes isolates in our laboratory between 1991 and 1995. We describe the clinical forms and establish the distribution over this period of time. METHODS:Retrospective survey of samples from outpatients of the Dermatology Service in Miguel Servet Hospita...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::Antimicrobial prophylaxis in surgery refers to a very brief course of an antimicrobial agent initiated just before the start of the procedure. The efficacy of antimicrobials to prevent postoperative infection at the site of surgery (incisional superficial, incisional deep, or organ/space infection) has been demonstrat...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:The Word Health Organization (WHO) has recommended epidemiologic surveillance of infection by the human immunodeficiency virus (HIV) in high risk populations. An important decrease has recently been observed in the prevalence of HIV infection in drug addicts in different regions in Spain with notable differe...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:The primary aim of this study was to evaluate associated factors, clinical features and prognosis of healthcare-related infective endocarditis cases compared with community-acquired and intravenous drug user-related episodes. Changes in the distribution of healthcare-related infective endoca...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2012.03.014
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Trypanosoma cruzi infection is a major imported parasitic disease in Spain, because of the increase of immigrants from endemic areas. Since the laboratory diagnosis during the chronic phase is based on detection of anti-T. cruzi IgG antibodies, our aims were to compare 10 tests for determining anti-T. cruz...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2009.07.005
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The influenza A (H1N1) 2009 pandemic initially had a mild impact in Catalonian hospitals, but in the autumn there was an important pandemic wave. We describe the main characteristics of patients seen in the Vall d'Hebron University Hospital in Barcelona (HUVH) during this pandemic, the risk fac...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2011.05.005
更新日期:2011-10-01 00:00:00
abstract::The disadvantages of the long-term administration of antiretroviral therapy as well as the huge number of affected persons have placed the cure of HIV as a primary goal of Public Health. HIV may persist in the organism by at least four mechanisms: a latently infected cellular reservoir, the persistent replication of H...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
doi:10.1016/j.eimc.2018.01.007
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Streptococcus pyogenes is a bacteria which, at present, is seldom isolated in blood and articular fluid. An intravenous drug addict with human immunodeficiency virus infection, with bacteremia and arthritis by S. pyogenes, associated with tuberculosis is presented. METHODS:Blood and articular fluid cultures...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract:INTRODUCTION:A gradual increase in severe cases due to Streptococcus pyogenes or Streptococcus beta-hemolytic group A (SGA), has been detected in the last few decades. METHODS:Retrospective study of bacteremia due to S.pyogenes detected between January 2009 and January 2013 in Cartagena. The annual incidence for sever...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2013.01.010
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of chronic colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients with cystic fibrosis, describe antibiotic sensitivity of the strains, and compare the patients' clinical characteristics with those of patients infected with methicillin-sensitive S. aureus ...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2008.02.008
更新日期:2009-02-01 00:00:00
abstract::Tuberculosis (TB) has affected humanity since the beginning of the recorded time and is associated with poverty, malnutrition, overcrowding, and immunosuppression. Since Koch discovered the infectious nature of the disease in 1882, knowledge about its history and physiopathology has advanced, but it continues to be a ...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
doi:10.1016/S0213-005X(11)70011-8
更新日期:2011-03-01 00:00:00
abstract::Atazanavir (ATV) is an HIV protease inhibitor (IP) with a high in vitro activity against HIV-1, that demonstrates a high additive activity in the presence of other antiretrovirals and a synergic activity with other PI. Oral absorption is greater than 68%, maximum concentration (C(max)) being reached approximately 2 to...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
doi:10.1016/S0213-005X(08)76613-8
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To study the possible viral etiology in 139 infants with lower respiratory tract infection who required hospitalization in the Infant Unit of our hospital, from October 1994 to June 1995. PATIENTS AND METHODS:139 patients were admitted, aged from 13 days to 14 months, during this period. The etiological agen...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::The relevance of mixed genital infections in our area was evaluated, and we report their clinical and epidemiological features for both viral types. We evaluated overall 54 Herpes simplex virus (HSV) isolates from 44 patients seen at the clinic of sexually transmitted diseases (STD) of the Sevilla School of Medicine d...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::Intraabdominal infections are severe with a high morbidity and mortality which may be produced by multiple causes: perforation of the empty viscera, intestinal inflammatory processes, vascular pictures, abdominal traumatisms as a consequence of surgery. From a microbiologic point of view, different types of gram posit...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:To provide an update of 2004 Guidelines from the Spanish AIDS Study Group (GESIDA) and the National AIDS Plan (PNS) committee on the prevention of opportunistic infections in adult and adolescent HIV-infected patients. METHODS:These consensus recommendations have been produced by a group of experts from GESI...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1157/13125642
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To describe the clinical experience with dalbavancin in the treatment of diabetic foot infection in a multidisciplinary unit of a second level hospital. METHODS:A retrospective, descriptive study was made with all patients with diabetic foot infection treated with dalbavancin in the Diabetic Foot Unit of Hos...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2020.11.013
更新日期:2021-01-12 00:00:00
abstract::Intestinal invagination is rather frequently associated with local tumors, adenovirus infections, and occasionally with Yersinia enterocolitica. However, in many cases the etiology is not known. We have studied 88 children with intestinal invagination in whom cellular cultures of Hep 2 and pulmonary fibroblasts of hum...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
doi:
更新日期:1990-08-01 00:00:00
abstract:INTRODUCTION:Vancomycin-resistant enterococci (VRE) among haemodialysis patients has increased rapidly and, to date, there is no report of this incidence in Portugal. METHODS:A total of 121 faecal samples were collected from haemodialysis patients, and then tested for VRE. Antimicrobial resistance, virulence and multi...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/j.eimc.2013.09.001
更新日期:2014-03-01 00:00:00
abstract::We report four patients (3 males and one female) suffering a sternoclavicular staphylococcal arthritis in whom risk factors such as parenteral drug addiction, alcoholism, diabetes, or immunosuppression were not observed. The etiopathogenesis, clinical picture, and diagnosis of this uncommon septic arthritis in reviewe...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::Pseudomonas aeruginosa, Acinetobacter baumannii and Stenotrophomonas maltophilia are, among others, the most important nonfermentative Gram-negative bacilli within hospitals. These organisms are able to cause different types of nosocomial infections in predisposed patients, and P. aeruginosa and A. baumannii in partic...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:10.1016/S0213-005X(11)70026-X
更新日期:2011-03-01 00:00:00