Abstract:
:Both N-methyl-D-aspartate (NMDA) and quisqualate/AMPA-insensitive metabotropic glutamate (mGlu) receptors mediate plasticity induction in neocortex, but their interlaminar distribution in cortical microcircuits is largely unknown. We used (+)(3)H-MK801 and (3)H-glutamate binding plus saturating concentrations of NMDA, AMPA, and quisqualate to autoradiographically map NMDA and mGlu receptor sites by lamina in posterior cingulate cortex in adult male rats. Specific binding at NMDA receptor sites in laminae II/III and VI was significantly reduced in comparison to other laminae. Brains prepared from rats killed during dark phase of a 12h/12h light/dark cycle showed a mean 129% increase in overall (+)(3)H-MK801 binding versus light phase brains but retained reduced binding densities in laminae II/III and VI. In contrast to NMDA findings, specific binding at mGlu sites was consistently elevated during light phase in both laminae II/III and VI. Specific (3)H-glutamate binding in dark-phase brains showed an overall 147% increase versus light phase binding but did not retain significant interlaminar heterogeneity. Interpreted in accordance with our physiologically derived models of hippocampo-cortical microcircuitry, these results suggest that spatial and temporal variations in glutamate receptor distribution may play an important role in intracingulate neural processing of afferent input from hippocampus.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Hedberg TG,Sperber EF,Velísková J,Moshé SLdoi
10.1152/jn.2000.84.4.1881subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1881-7issue
4eissn
0022-3077issn
1522-1598journal_volume
84pub_type
杂志文章abstract::Unitary discharge patterns (peristimulus time histograms or PSTH) and synaptic events were studies with intracellular recording techniques in 164 cat cochlear nucleus cells to steady-frequency tone bursts 250 ms in duration. There were four response types defined on the basis of the shape of the discharge patterns to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
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journal_title:Journal of neurophysiology
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journal_title:Journal of neurophysiology
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doi:10.1152/jn.2000.84.1.581
更新日期:2000-07-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:1991-04-01 00:00:00
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