Influence of low doses of gamma-irradiation on mouse skin collagen fibrils.

Abstract:

:The structure of mouse skin collagen fibrils after treatment with 0.5, 1 and 2.5 Gy gamma-irradiation was studied by electron microscopy. Animals were sacrificed 1, 4 and 8 weeks after irradiation. Although there were areas where the normal parallel packing of fibrils was retained in some regions packing was interrupted by abnormal fibrils and in some cases helical twisting was apparent. Irradiated collagen fibrils had a lower mean diameter compared with normal and a large variability in width. The diameter of 0.5 Gy irradiated fibrils returned to normal by 4 or 8 weeks after irradiation. Clusters of abnormal fibrils were found when viewed in cross-sections. Their number and size was reversibly dependent on the dose level. All fibrils retained normal banding periodicity. Computer analysis of irradiated and control patterns led to the conclusion that 0.5-2.5 Gy gamma-irradiation had no considerable effect in modifying the charge distribution along the mouse skin collagen fibril.

journal_name

Int J Radiat Biol

authors

Tzaphlidou M,Kounadi E,Leontiou I,Matthopoulos DP,Glaros D

doi

10.1080/095530097144481

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

109-15

issue

1

eissn

0955-3002

issn

1362-3095

journal_volume

71

pub_type

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