Modulation of the ERK pathway of signal transduction by cysteine proteinase inhibitors.

abstract：:Resistance to therapies, recurrence, and metastasis remain challenging issues for breast cancer patients, particularly for triple-negative and breast cancer stem cells. The activation of the epithelial-to-mesenchymal transition (EMT) plays an indispensable role in the poor prognosis of those types. The accumulating pr...

journal_title：Journal of cellular biochemistry

authors： Koohestanimobarhan S,Salami S,Imeni V,Mohammadi Z,Bayat O

更新日期：2018-09-06 00:00:00

abstract：:Poor clinical outcomes of tendon repair, together with limited regenerative capacity of the tissue, have triggered the search for alternative regenerative medicine strategies. Human adipose-derived stem cells (hASCs) are being investigated as a promising cell source in contributing for tendon repopulation and reconstr...

journal_title：Journal of cellular biochemistry

authors： Costa-Almeida R,Berdecka D,Rodrigues MT,Reis RL,Gomes ME

更新日期：2018-04-01 00:00:00

abstract：:The levels of organic pollutants, such as optical brightener (OB) compounds, in the global environment have been increasing in recent years. The toxicological effects and signal transduction systems associated with OB toxicity have not been thoroughly studied. The ubiquitin-proteasome system (UPS) plays a crucial role...

journal_title：Journal of cellular biochemistry

authors： Castro I,Ekinci E,Huang X,Cheaito HA,Ahn YH,Olivero-Verbel J,Dou QP

更新日期：2019-08-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL), a severe problem all over the world and represents around 25% of all total leukemia cases, is generating the need for novel targets against CLL. Wnt signaling cascade regulates cell proliferation, differentiation, and cell death processes. Thus, any alteration of the Wnt signaling p...

journal_title：Journal of cellular biochemistry

authors： Bhattacharya M,Sharma AR,Sharma G,Patra BC,Lee SS,Chakraborty C

更新日期：2020-11-01 00:00:00

abstract：:Adamts17 is a member of a family of secreted metalloproteinases. In this report, we show that knockdown of Adamts17 expression induces apoptosis and inhibits breast cancer cell growth. Adamts17 expression can rapidly be induced by estrogens. siRNA knockdown of Sp1 or Myc demonstrated that Sp1 is required to induce Ada...

journal_title：Journal of cellular biochemistry

authors： Jia Z,Gao S,M'Rabet N,De Geyter C,Zhang H

更新日期：2014-10-01 00:00:00

abstract：:The inhibitor of growth (ING) family of proteins is an evolutionarily conserved family, with members present from yeast to humans. The mammalian ING proteins are candidate tumor suppressor proteins and accordingly can cooperate with p53 to arrest proliferation and induce apoptosis. ING proteins are also reported to fu...

journal_title：Journal of cellular biochemistry

authors： Shi X,Gozani O

更新日期：2005-12-15 00:00:00

abstract：:Proper bone remodeling requires an active process of angiogenesis which in turn supplies the necessary growth factors and stem cells. This tissue cooperation suggests a cross-talk between osteoblasts and endothelial cells. This work aims to identify the role of paracrine communication through vascular endothelial grow...

journal_title：Journal of cellular biochemistry

authors： Grellier M,Ferreira-Tojais N,Bourget C,Bareille R,Guillemot F,Amédée J

更新日期：2009-02-15 00:00:00

abstract：:Acid-electrolyzed functional water (FW) is obtained through the electrolysis of sodium chloride solution. Stimulation of the human fibroblastic cell line HeLa by FW led to the augmented secretion of basic fibroblast growth factor (bFGF). Immunoprecipitation followed by Western blot analysis revealed that both high and...

journal_title：Journal of cellular biochemistry

authors： Motozawa K,Motoyoshi M,Saiki A,Sasaki H,Shimizu N,Asano M

更新日期：2018-09-01 00:00:00

abstract：:Stroke is one of the most destructive complications of sickle cell disease (SCD), and SCD is also the most common cause of childhood stroke. Sickle cell stroke is complex and has a genetic endothelial basis. Here, we further investigated this genetic basis using weighted gene coexpression network analysis. This system...

journal_title：Journal of cellular biochemistry

authors： Liu FF,Wang J,Hu F,Wei Q,Li K

更新日期：2019-09-01 00:00:00

abstract：:This study aims to investigate the combined effects of Pulsed wave low-level laser therapy (PW LLLT) and human bone marrow mesenchymal stem cell-conditioned medium (hBM-MSC-CM) on the microbial flora and tensiometrical properties of an infected wound model with methicillin-resistant staphylococcal aureus (MRSA) in an ...

journal_title：Journal of cellular biochemistry

authors： Kouhkheil R,Fridoni M,Piryaei A,Taheri S,Chirani AS,Anarkooli IJ,Nejatbakhsh R,Shafikhani S,Schuger LA,Reddy VB,Ghoreishi SK,Jalalifirouzkouhi R,Chien S,Bayat M

更新日期：2018-07-01 00:00:00

abstract：:Avian influenza viruses (AIV) are very active in several parts of the globe and are the cause of huge economic loss for the poultry industry and also human fatalities. Three dimensional modeling was carried out for neuraminidase (NA) and hemagglutinin (HA) proteins of AIV. The C-score, estimated TM-Score, and estimate...

journal_title：Journal of cellular biochemistry

authors： Ramamurthy M,Sankar S,Abraham AM,Nandagopal B,Sridharan G

更新日期：2019-10-01 00:00:00

abstract：:Small molecule inhibitors of cyclin-dependent kinase 5 (CDK5) protect neurons from cell death following various insults. To elucidate the cellular mechanism of action we investigated changes in protein phosphorylation in cultured rat cerebellar granule neurons after administration of the CDK5 inhibitor Indolinone A. B...

journal_title：Journal of cellular biochemistry

authors： Gillardon F,Schrattenholz A,Sommer B

更新日期：2005-07-01 00:00:00

abstract：:Bladder cancer-associated transcript 1 (BLACAT1) is a novel identified long noncoding RNA (lncRNA) in bladder cancer, and has been suggested to function as an oncogenic lncRNA in several types of human cancer. However, its involvement in the progression of small-cell lung cancer (SCLC) remained unknown. The aim of our...

journal_title：Journal of cellular biochemistry

authors： Chen W,Hang Y,Xu W,Wu J,Chen L,Chen J,Mao Y,Song J,Song J,Wang H

更新日期：2018-09-11 00:00:00

abstract：:Adiponectin is an important insulin-sensitizing adipokine with multiple beneficial effects on obesity-associated medical complications. It is secreted from adipocytes into circulation as high, medium, and low molecular weight forms (HMW, MMW, and LMW). Each oligomeric form of adiponectin exerts non-overlapping biologi...

journal_title：Journal of cellular biochemistry

authors： Chen Z,Zhang L,Yi J,Yang Z,Zhang Z,Li Z

更新日期：2012-11-01 00:00:00

abstract：:During neonatal development, cardiac myocytes undergo a transition from hyperplastic to hypertrophic growth. Whether these cells are terminally differentiated and permanently withdrawn from the cell cycle shortly after birth is controversial. Nevertheless, the clinical observation that functionally significant myocard...

journal_title：Journal of cellular biochemistry

authors： Chim SS,Fung K,Waye MM,Lee C,Tsui SK

更新日期：2000-06-12 00:00:00

abstract：:Curcumin, the main ingredient of Curcuma longa L., has been used as a spice and as a herbal medicine with different therapeutic characteristics for centuries in Asian countries. This phytochemical has been shown to possess beneficial antiplatelet activity that has introduced it as a promising candidate for the treatme...

journal_title：Journal of cellular biochemistry

authors： Tabeshpour J,Hashemzaei M,Sahebkar A

更新日期：2018-11-01 00:00:00

abstract：:Glutathione S-transferases (GSTs, EC 2.5.1.18) belong to a large family of functionally different enzymes that catalyze the S-conjugation of glutathione with a wide variety of electrophilic compounds including carcinogens and anticancer drugs. Drug resistance may result from reduction in apoptosis of neoplastic cells ...

journal_title：Journal of cellular biochemistry

authors： Bernardini S,Bernassola F,Cortese C,Ballerini S,Melino G,Motti C,Bellincampi L,Iori R,Federici G

更新日期：2000-04-01 00:00:00

abstract：:Our study was aimed to investigate the mechanism of rs4759314 located in HOTAIR involved in congenital heart disease. Luciferase assay was performed to evaluate whether rs4759314 affected the transcription efficiency of HOTAIR promoter, and confirm miR-545 target gene. Real-time PCR, Western-blot and IHC were carried ...

journal_title：Journal of cellular biochemistry

authors： Li Y,Zhao W,Shi R,Jia J,Li X,Cheng J

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Long intergenic noncoding RNA-p21 (lincRNA-p21) has been proved in the pathogenesis of aortic aneurysms, while its functionality in thoracic aortic aneurysms (TAA) and the mechanism of function remains unclear. Therefore our study aimed to investigate the role of lincRNA-p21 in TAA. METHODS:Aortic media spec...

journal_title：Journal of cellular biochemistry

authors： Hu W,Wang Z,Li Q,Wang J,Li L,Jiang G

更新日期：2019-03-01 00:00:00

abstract：:Thrombin increases the cytosolic Ca(2+) concentrations and induces NO production by activating proteinase-activated receptor 1 (PAR(1)) in vascular endothelial cells. The store-operated Ca(2+) influx is a major Ca(2+) influx pathway in non-excitable cells including endothelial cells and it has been reported to play a ...

journal_title：Journal of cellular biochemistry

authors： Hirano K,Hirano M,Hanada A

更新日期：2009-10-01 00:00:00

abstract：:We have a long-standing interest in a nuclear protease which appears to be involved in carcinogenesis. We recently identified the protease as high temperature requirement factor A 1 (HtrA1), also known as Prss11, which is member of an oxidative stress-response family of proteases. HtrA1 has been classified as a secret...

journal_title：Journal of cellular biochemistry

authors： Clawson GA,Bui V,Xin P,Wang N,Pan W

更新日期：2008-09-01 00:00:00

abstract：:Malignant gliomas, the most common subtype of primary brain tumors, are characterized by high proliferation, great invasion, and neurological destruction and considered to be the deadliest of human cancers. Analgesic-antitumor peptide (AGAP), one of scorpion toxic polypeptides, has been shown to have antitumor activit...

journal_title：Journal of cellular biochemistry

authors： Zhao Y,Cai X,Ye T,Huo J,Liu C,Zhang S,Cao P

更新日期：2011-09-01 00:00:00

abstract：:Several gap junction connexins have been shown to be essential for appropriate placental development and function. It is known that the expression and distribution of connexins change in response to environmental oxygen levels. The placenta develops under various oxygen levels, beginning at a low oxygen tension of app...

journal_title：Journal of cellular biochemistry

authors： Otto T,Gellhaus A,Lüschen N,Scheidler J,Bendix I,Dunk C,Wolf N,Lennartz K,Köninger A,Schmidt M,Kimmig R,Fandrey J,Winterhager E

更新日期：2015-12-01 00:00:00

abstract：:Human prostate cancers (PCa) express great variability in their ability to metastasize to bone. The identification of molecules associated with aggressive phenotypes will help to define PCa subsets and will ultimately lead to better treatment strategies. The chemokine stromal-derived factor-1 (SDF-1 or CXCL12) and its...

journal_title：Journal of cellular biochemistry

authors： Sun YX,Wang J,Shelburne CE,Lopatin DE,Chinnaiyan AM,Rubin MA,Pienta KJ,Taichman RS

更新日期：2003-06-01 00:00:00

abstract：:The human myeloid nuclear differentiation antigen (MNDA) is expressed specifically in maturing cells of the myelomonocytic lineage and in monocytes and granulocytes. Epitope enhancement was used to confirm the strict lineage- and stage-specific expression of MNDA in bone marrow as well as in other paraffin-embedded fi...

journal_title：Journal of cellular biochemistry

authors： Kao WY,Briggs JA,Kinney MC,Jensen RA,Briggs RC

更新日期：1997-05-01 00:00:00

abstract：:The current study was conducted to assess the relationship between testicular cells in spermatogenesis, through which the production of healthy and mature sperm is essential. However, it seems necessary to obtain more information about the three-dimensional pattern of the testis cells arrangement, which is directly re...

journal_title：Journal of cellular biochemistry

authors： Sajadi E,Dadras S,Bayat M,Abdi S,Nazarian H,Ziaeipour S,Mazini F,Kazemi M,Bagheri M,Valizadeh A,Abdollahifar MA

更新日期：2019-10-01 00:00:00

abstract：:Endometrial cancer is one of the most common gynecological malignant tumors. The roles of competing endogenous RNAs (ceRNAs) in this disease, however, remain unclear. In this study, we constructed a ceRNA network to reveal the core ceRNAs in endometrial cancer. Differentially expressed genes were summarized from The C...

journal_title：Journal of cellular biochemistry

authors： Wang Y,Huang T,Sun X,Wang Y

更新日期：2019-11-01 00:00:00

abstract：:Gastric cancer (GC) is the fifth most frequent cancer and the third-leading cause of cancer-related death worldwide. It is a highly heterogeneous disease regarding the morphological and molecular viewpoints. Since it is curable in primary stages, early detection could improve the survival rate. Long noncoding RNAs con...

journal_title：Journal of cellular biochemistry

authors： Kangarlouei R,Irani S,Noormohammadi Z,Memari F,Mirfakhraie R

更新日期：2019-08-01 00:00:00

abstract：:The presented results show for the first time that the neurogenic transdifferentiation of hUC-MSCs considerably changes the elements of purinergic signaling profile. Although, it has been demonstrated in the literature that extracellular nucleotides and nucleosides determine the fate of mesenchymal and neural stem cel...

journal_title：Journal of cellular biochemistry

authors： Czarnecka J,Porowińska D,Bajek A,Hołysz M,Roszek K

更新日期：2017-03-01 00:00:00

abstract：:The interaction of cancer cells with extracellular matrix (ECM) is important in metastasization. Here we identified the molecules of the ECM expressed by sarcomatous malignant mesothelioma, and their effect on adhesion and spreading. In addition, by analyzing the relationship between translation and attachment to matr...

journal_title：Journal of cellular biochemistry

authors： Ranzato E,Grosso S,Patrone M,Betta PG,Viarengo A,Biffo S

更新日期：2009-11-01 00:00:00