Impact of flavophospholipol and vancomycin on conjugational transfer of vancomycin resistance plasmids.

abstract：:In vitro studies of zidovudine (ZDV) phosphorylation may not accurately reflect the in vivo dose-response relationship, which is crucial to determining the relationship between ZDV exposure, efficacy, and toxicity. However, measurement of ZDV phosphorylated anabolites in peripheral blood mononuclear cells (PBMCs) from...

journal_title：Antimicrobial agents and chemotherapy

authors： Slusher JT,Kuwahara SK,Hamzeh FM,Lewis LD,Kornhauser DM,Lietman PS

更新日期：1992-11-01 00:00:00

abstract：:An experiment was conducted in animal facilities to compare the impacts of four avian colibacillosis treatments-oxytetracycline (OTC), trimethoprim-sulfadimethoxine (SXT), amoxicillin (AMX), or enrofloxacin (ENR)-on the susceptibility of Escherichia coli in broiler intestinal tracts. Birds were first orally inoculated...

journal_title：Antimicrobial agents and chemotherapy

authors： Dheilly A,Le Devendec L,Mourand G,Bouder A,Jouy E,Kempf I

更新日期：2012-01-01 00:00:00

abstract：:The activity of MK-0826, a new carbapenem, against 309 Bacteroides fragilis group strains was investigated and compared with that of 11 other beta-lactam and 5 non-beta-lactam agents. MK-0826 showed excellent activity (MICs ranged from < or =0.06 to 4 microg/ml). The new carbapenem may be useful in the treatment of mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Betriu C,Sánchez A,Palau ML,Gómez M,Picazo JJ

更新日期：2001-08-01 00:00:00

abstract：:The killing of Candida albicans by a series of amphiphilic quaternary ammonium compounds (QACs) with different hydrocarbon chain lengths was closely related to the binding of the compounds to the cells and damage of the cell membranes. The membrane damage was measured as the level of release of the UV-absorbing materi...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahlström B,Chelminska-Bertilsson M,Thompson RA,Edebo L

更新日期：1997-03-01 00:00:00

abstract：:Against 443 aerobic and anaerobic bacteria isolated from diabetic foot infections, ceftobiprole MICs (microg/ml) at which 90% of the isolates tested were inhibited were as follows: methicillin-resistant Staphylococcus aureus, 1; methicillin-susceptible S. aureus and Staphylococcus lugdunensis, 0.5; Anaerococcus prevot...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Merriam CV,Warren YA,Tyrrell KL,Fernandez HT

更新日期：2006-11-01 00:00:00

abstract：:PD 131628 is a new aminopyrrolidine-substituted fluorocyclopropyl naphthyridine quinolone which possesses high in vitro activity against a wide spectrum of bacterial species. The MICs for greater than or equal to 90% of strains were 0.125 to 0.25 microgram/ml for staphylococci, Streptococcus pyogenes, and S. pneumonia...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohen MA,Huband MD,Mailloux GB,Yoder SL,Roland GE,Domagala JM,Heifetz CL

更新日期：1991-01-01 00:00:00

abstract：:Enzyme-mediated immunoassay (EMIT) serum aminoglycoside assay results were accurate and precise and correlated well with radioimmunoassay, fluoroimmunoassay, and acetyltransferase and microbiological assay determinations. ...

journal_title：Antimicrobial agents and chemotherapy

authors： White LO,Scammell LM,Reeves DS

更新日期：1981-06-01 00:00:00

abstract：:We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achieva...

journal_title：Antimicrobial agents and chemotherapy

authors： Li Y,Nguyen MH,Derendorf H,Cheng S,Clancy CJ

更新日期：2007-08-01 00:00:00

abstract：:A-837093 is a potent and specific nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase. It possesses nanomolar potencies in both enzymatic and replicon-based cell culture assays. In rats and dogs this compound demonstrated an oral plasma half-life of great...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen CM,He Y,Lu L,Lim HB,Tripathi RL,Middleton T,Hernandez LE,Beno DW,Long MA,Kati WM,Bosse TD,Larson DP,Wagner R,Lanford RE,Kohlbrenner WE,Kempf DJ,Pilot-Matias TJ,Molla A

更新日期：2007-12-01 00:00:00

abstract：:Berberine sulfate is an alkaloid extracted from the roots and bark of various plants and possesses antibacterial, antifungal, and antiprotozoal activities. Most studies have focused on the bacteriostatic or bactericidal activities of this compound. In this study, we report that berberine sulfate is bacteriostatic for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun D,Courtney HS,Beachey EH

更新日期：1988-09-01 00:00:00

abstract：:We have used the endogenous reverse transcriptase reaction of viral core particles from duck liver to elucidate the mechanism of inhibition of duck hepatitis B virus (DHBV) replication by the nucleoside analog (-)-beta-L-2',3'-dideoxy-3'-thiacytidine (3TC). As is the case in human immunodeficiency virus replication, 3...

journal_title：Antimicrobial agents and chemotherapy

authors： Severini A,Liu XY,Wilson JS,Tyrrell DL

更新日期：1995-07-01 00:00:00

abstract：:Imipenem-cilastatin concentrations in bile were measured in 12 cholecystectomy patients (group 1) and 12 patients with common duct drainage (group 2). Six patients in each group received 0.5 g, and six received 1.0 g intravenously over 30 to 60 min. In group 1, bile was collected a mean of 85 min postinfusion. The mea...

journal_title：Antimicrobial agents and chemotherapy

authors： Graziani AL,Gibson GA,MacGregor RR

更新日期：1987-11-01 00:00:00

abstract：:Two antilipidemic compounds, clofibrate and procetofene, inhibited the replication of herpes simplex virus type 1 (HSV-1) in African green monkey kidney cells. Clofibrate, at a concentration of 400 mumol/liter caused a 63% reduction (P < 0.001) in HSV-1 yield and at 100 mumol/liter caused a 62% reduction (P < 0.001) i...

journal_title：Antimicrobial agents and chemotherapy

authors： Mehl JK,Witiak DT,Hamparian VV,Hughes JH

更新日期：1980-08-01 00:00:00

abstract：:The in vitro activities of seven fluoroquinolones against 290 anaerobes were determined by agar dilution. CI-960 and WIN 57273 inhibited greater than 95% of the strains at less than or equal to 2 micrograms/ml. CI-990 required less than or equal to 16 micrograms/ml. Clustering around 2 to 4 micrograms/ml was noted for...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM

更新日期：1992-05-01 00:00:00

abstract：:Acute pulmonary exacerbations (APE) involving Pseudomonas aeruginosa are associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Drug resistance is a significant challenge to treatment. Ceftazidime-avibactam (CZA) demonstrates excellent in vitro activity against isolates recovered from CF p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bensman TJ,Wang J,Jayne J,Fukushima L,Rao AP,D'Argenio DZ,Beringer PM

更新日期：2017-09-22 00:00:00

abstract：:Perturbation of hydroxyl radical accumulation by subinhibitory concentrations of 2,2'-bipyridyl plus thiourea protects Escherichia coli from being killed by 3 lethal antimicrobial classes. Here, we show that 2,2'-bipyridyl plus thiourea delays and/or reduces antimicrobial killing of Staphylococcus aureus by daptomycin...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu Y,Liu X,Qu Y,Wang X,Li L,Zhao X

更新日期：2012-11-01 00:00:00

abstract：:Among hospitalized adults who received vancomycin for their skin and skin structure infection (SSSI), patients who experienced acute kidney injury (AKI) had considerably higher 30-day readmission rates. Nearly half of the observed 30-day readmissions were due to non-SSSI-related reasons, which is consistent with the p...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel N,Stornelli N,Sangiovanni RJ,Huang DB,Lodise TP

更新日期：2020-09-21 00:00:00

abstract：:Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity of antimicrobials is now evolving. We evaluated the potential for synergy of colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidaillac C,Benichou L,Duval RE

更新日期：2012-09-01 00:00:00

abstract：:The kinetics of the lethal action of metronidazole and the formation of acetamide have been studied in a strain of Bacteroides fragilis which is relatively resistant to metronidazole. As with a susceptible strain of B. fragilis, the data are consistent with a model in which a labile intermediate in metronidazole metab...

journal_title：Antimicrobial agents and chemotherapy

authors： McLafferty MA,Koch RL,Goldman P

更新日期：1982-01-01 00:00:00

abstract：:Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of w...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong Y,Creek D,Chollet J,Matile H,Charman SA,Wittlin S,Wood JK,Vennerstrom JL

更新日期：2007-08-01 00:00:00

abstract：:Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population...

journal_title：Antimicrobial agents and chemotherapy

authors： Francis J,Barnes KI,Workman L,Kredo T,Vestergaard LS,Hoglund RM,Byakika-Kibwika P,Lamorde M,Walimbwa SI,Chijioke-Nwauche I,Sutherland CJ,Merry C,Scarsi KK,Nyagonde N,Lemnge MM,Khoo SH,Bygbjerg IC,Parikh S,Aweeka FT,

更新日期：2020-04-21 00:00:00

abstract：:A self-transferable plasmid of ca. 80 kb, pIP1204, conferred multiple-antibiotic resistance to Klebsiella pneumoniae BM4536, which was isolated from a urinary tract infection. Resistance to beta-lactams was due to the bla(TEM1) and bla(CTX-M) genes, resistance to trimethroprim was due to the dhfrXII gene, resistance t...

journal_title：Antimicrobial agents and chemotherapy

authors： Galimand M,Courvalin P,Lambert T

更新日期：2003-08-01 00:00:00

abstract：:Presently, therapy of eumycetoma in Sudan is still based on surgery combined with prolonged ketoconazole therapy. This usually results in a poor clinical outcome. To determine if posaconazole and terbinafine could offer better therapeutic alternatives, the in vitro susceptibilities of 34 Madurella mycetomatis strains ...

journal_title：Antimicrobial agents and chemotherapy

authors： van Belkum A,Fahal AH,van de Sande WW

更新日期：2011-04-01 00:00:00

abstract：:Mycobacterium smegmatis is a fast-growing nonpathogenic species particularly useful in studying basic cellular processes of relevance to pathogenic mycobacteria. This study focused on the D-alanine racemase gene (alrA), which is involved in the synthesis of D-alanine, a basic component of peptidoglycan that forms the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chacon O,Feng Z,Harris NB,Cáceres NE,Adams LG,Barletta RG

更新日期：2002-01-01 00:00:00

abstract：:A novel gene encoding an aminoglycoside 3-N-acetyltransferase, which confers resistance to gentamicin, astromicin, and sisomicin, was cloned from Pseudomonas aeruginosa Stone 130. Its sequence was determined and found to show considerable similarity to an aac(3)-I gene previously cloned from R plasmids from Enterobact...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwocho LR,Schaffner CP,Miller GH,Hare RS,Shaw KJ

更新日期：1995-08-01 00:00:00

abstract：:Nucleoside reverse transcriptase inhibitors (NRTIs) used against the human immunodeficiency virus (HIV) need to be activated intracellularly to their triphosphate moiety to inhibit HIV replication. Intracellular concentrations of these NRTI triphosphates, especially zidovudine triphosphate (ZDV-TP), are relatively low...

journal_title：Antimicrobial agents and chemotherapy

authors： Font E,Rosario O,Santana J,García H,Sommadossi JP,Rodriguez JF

更新日期：1999-12-01 00:00:00

abstract：:We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against repl...

journal_title：Antimicrobial agents and chemotherapy

authors： Speer A,Shrestha TB,Bossmann SH,Basaraba RJ,Harber GJ,Michalek SM,Niederweis M,Kutsch O,Wolschendorf F

更新日期：2013-02-01 00:00:00

abstract：:We collected 1,353 strains of beta-hemolytic streptococci of groups A, B, C, and G (1,176 strains of which were group A) isolated in 26 institutions throughout Japan in 1972-1974. The strains were grouped and T-typed by our specific group-and T-factor sera, and the minimal inhibitory concentrations of 10 antibiotics w...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyamoto Y,Takizawa K,Matsushima A,Asai Y,Nakatsuka S

更新日期：1978-03-01 00:00:00

abstract：:Malaria is the third most significant cause of infectious disease in the world. The search for new antimalarial chemotherapy has become increasingly urgent due to parasite resistance to classical drugs. Trioxaquines are synthetic hybrid molecules containing a trioxane motif (which is responsible for the antimalarial a...

journal_title：Antimicrobial agents and chemotherapy

authors： Benoit-Vical F,Lelièvre J,Berry A,Deymier C,Dechy-Cabaret O,Cazelles J,Loup C,Robert A,Magnaval JF,Meunier B

更新日期：2007-04-01 00:00:00

abstract：:Macrolide-resistant Mycoplasma pneumoniae (MR M. pneumoniae) has been isolated from clinical specimens in Japan since 2000. A comparative study was carried out to determine whether or not macrolides are effective in treating patients infected with MR M. pneumoniae. The clinical courses of 11 patients with MR M. pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Suzuki S,Yamazaki T,Narita M,Okazaki N,Suzuki I,Andoh T,Matsuoka M,Kenri T,Arakawa Y,Sasaki T

更新日期：2006-02-01 00:00:00