Abstract：
:The pathogenesis of reversible cupping of the optic disk in congenital glaucoma was examined by two approaches. Human fetal, neonatal, and adult eyes were examined by histochemistry and electron microscopy to delineate the embryologic development of the optic nerve head. While the neural, glial, and vascular elements of the nerve head attain their adult configuration by midgestation, the connective tissues of the lamina cribrosa are incompletely developed at birth. The response of the optic disk cup to elevated intraocular pressure (IOP) was observed in enucleated infant and adult eyes. While no disk changes were seen in adult eyes subjected to an IOP up to 90 mm Hg for 24 hours, enlargement of the disk cup in infant eyes was documented photographically and histologically after eight to 24 hours of IOP elevations to 50 mg Hg. Reversible cupping in congenital glaucoma can be best explained by compression or posterior movement of optic disk tissues--a result of the incomplete collagenous structural framework of the lamina cribrosa during late gestation and early neonatal life.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Quigley HAdoi
10.1016/0002-9394(77)90680-8subject
Has Abstractpub_date
1977-09-01 00:00:00pages
358-70issue
3eissn
0002-9394issn
1879-1891pii
0002-9394(77)90680-8journal_volume
84pub_type
杂志文章abstract：PURPOSE:To investigate the rate of progressive visual field (VF) loss and associated factors for structural or functional progression in preperimetric open-angle glaucoma (OAG). DESIGN:Longitudinal, observational study. METHODS:We included 127 eyes of 127 preperimetric OAG patients who were treated with topical medic...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.10.010
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:To report microvascular retinopathy after percutaneous transluminal coronary angioplasty and stent insertion for acute myocardial infarction. DESIGN:Observational case series. METHODS:Retrospective review of seven patients with a retinal microangiopathy following coronary catheterization, angioplasty, and ste...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00267-8
更新日期：2003-09-01 00:00:00
abstract：:Ten patients with Stargardt's disease and 14 with fundus flavimaculatus underwent thorough ophthalmic examinations, retinal photography, and, when possible, fluorescein angiography. Retinal function was also assessed by static and kinetic perimetry, the Farnsworth-Munsell 100-hue test, electro-oculography, and electro...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(83)90455-5
更新日期：1983-07-01 00:00:00
abstract：PURPOSE:To analyze the biological stability of autologous serum eyedrops after lyophilization. DESIGN:Prospective, comparative experimental study. METHODS:This was a comparative study with serum obtained from 12 healthy volunteers. The concentrations of different epitheliotropic factors (eg, transforming growth facto...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.01.027
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:To evaluate the effect of contact lens (CL) wear and visual display terminal (VDT) work on the ocular surface and tear functions. DESIGN:Prospective case-control study. METHODS:Sixty-nine CL wearers (45 women and 24 men; mean age, 35.2 ± 7.3 years), and 102 age- and sex-matched non-CL wearers were enrolled in...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.05.025
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To study the appearance of margins of geographic atrophy in high-resolution optical coherence tomography (OCT) images and to correlate those changes with fundus autofluorescence (FAF) imaging. DESIGN:Retrospective, observational case study. METHODS:Patients with geographic atrophy secondary to dry age-related...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.04.022
更新日期：2009-09-01 00:00:00
abstract：:A white male infant was born with multiple hemangiomas of the skin and mucous membrane. At 7 months of age he exhibited the signs and symptoms of infantile glaucoma in each eye, but goniotomy was not possible because of vascularity in the angles. Cyclocryotherapy was used on multiple occasions to control intraocular p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90733-9
更新日期：1976-02-01 00:00:00
abstract：PURPOSE:To report a case of bilateral acute retinal necrosis caused by cytomegalovirus. METHODS:A diagnostic vitrectomy was performed on a patient with non-Hodgkin lymphoma who presented with a bilateral, rapidly progressing necrotizing retinitis and uveitis. RESULTS:Immunohistochemical studies and polymerase chain r...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00250-5
更新日期：1999-01-01 00:00:00
abstract：:We compared the intraocular pressure-decreasing effect of timolol maleate alone, acetazolamide alone, and combined timolol and acetazolamide therapy in nine patients with bilateral chronic open-angle glaucoma. Timolol decreased intraocular pressure at least as effectively as acetazolamide. The two medications together...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75631-4
更新日期：1981-12-01 00:00:00
abstract：PURPOSE:To report a case of primary intraocular lymphoma possessing bilaterally identical monoclonal rearrangements of the immunoglobulin heavy chain (IgH) gene. DESIGN:Observational case report. METHODS:A 78-year-old woman with bilateral vitritis, subretinal infiltrates in the right eye, and no involvement of the ce...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.03.003
更新日期：2004-08-01 00:00:00
abstract：PURPOSE:To investigate whether abnormal glucose metabolism and duration of diabetes mellitus (DM) affected the corneal and lens clarity in children with well-controlled type 1 DM and to compare the results obtained with those in healthy children. DESIGN:Cross-sectional prospective study. METHODS:This multicenter stud...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2017.05.010
更新日期：2017-07-01 00:00:00
abstract：:We have constructed an ophthalmic fixation device that stabilizes an enucleated eye, and helps both in the pathologic examination of the eye and in ophthalmic practice surgery. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74929-3
更新日期：1980-09-01 00:00:00
abstract：:Four patients (three men, 68, 35, and 33 years old, and one woman, 46 years old) had central serous elevation of the macula with abnormal latency of the visual-evoked potential and spontaneous Pulfrich phenomenon. In three instances both the electrophysiologic test and the clinical Pulfrich test reverted to normal on ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90684-1
更新日期：1985-10-15 00:00:00
abstract：:Pars plana vitrectomy and scleral buckling were performed on 22 eyes of 19 patients for treatment of perforating eye injuries from shotgun pellets. We reviewed the intraoperative findings at the time of vitrectomy to determine what factors might influence final visual acuity. The presence of a total retinal detachment...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77416-1
更新日期：1992-07-15 00:00:00
abstract：PURPOSE:To report donor-to-host transmission of Candida albicans after penetrating keratoplasty. DESIGN:Interventional case report. METHODS:A 15-year-old boy who underwent penetrating keratoplasty for keratoconus with donor tissue from a drowning victim developed keratitis and a lenticular abscess 26 days postoperati...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01427-7
更新日期：2002-07-01 00:00:00
abstract：PURPOSE:To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PCIOLs) performed in combination with pars plana vitrectomy. DESIGN:Retrospective, consecutive, interventional case series. METHODS:Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina C...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.01.034
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:To assess the efficacy of intravitreous fomivirsen sodium, an antisense oligonucleotide, for newly diagnosed peripheral cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS). DESIGN:Randomized treatment intervention clinical trial. METHODS:A multicenter, prospective, and r...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0002-9394(02)01327-2
更新日期：2002-04-01 00:00:00
abstract：PURPOSE:To determine the association between anticytomegalovirus (CMV) maintenance therapy after immune recovery and immune recovery uveitis in acquired immunodeficiency syndrome (AIDS) patients on highly active antiretroviral therapy (HAART). DESIGN:Observational cohort study. METHODS:Data were obtained on AIDS pati...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00335-0
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:To evaluate the impact of cataract surgery on subfoveal choroidal thickness and central retinal thickness in the elderly. DESIGN:Prospective observational case series. METHODS:This cohort study included 29 eyes of 29 patients with senile cataract, but no previous ocular surgery or other ocular abnormality. Al...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.05.016
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:Descemet membrane endothelial keratoplasty is a new technique for the replacement of diseased corneal endothelium with healthy donor endothelium. During this procedure, manipulation of the donor endothelium-Descemet membrane layer within the recipient anterior chamber can be associated with loss of the correct ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.01.005
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To investigate visual function and optical quality in eyes with epiphora undergoing lacrimal passage intubation. DESIGN:Prospective case series. METHODS:Thirty-four eyes of 30 patients with lacrimal passage obstruction were enrolled. Before and 1 month after lacrimal passage intubation, functional visual acui...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.06.022
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:To report the trends in intraocular pressures (IOP) within the first week after intravitreal injection of triamcinolone acetonide (Kenalog) for the treatment of retinal disease. DESIGN:Retrospective chart review. METHODS:Review of 43 consecutive patients and 50 intravitreal injections of 4 mg triamcinolone ac...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.08.033
更新日期：2007-02-01 00:00:00
abstract：PURPOSE:To assess indocyanine green angiography (ICGA) as a method for monitoring autograft perfusion after pterygium excision with limbal-conjunctival autograft transplantation (LCAT) and to compare ICGA with anterior segment fluorescein angiography (ASFA). DESIGN:Nonrandomized prospective interventional case series....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01834-2
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:To evaluate the diagnostic performance characteristics of the Van Herick assessment (VHA) for identifying angle closure compared to gold-standard gonioscopy, as conducted by trained observers of varying expertise. DESIGN:Reliability analysis. METHODS:Patients (n = 131) from a glaucoma referral clinic aged ≥50...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.07.026
更新日期：2018-11-01 00:00:00
abstract：:Fine-needle aspiration was used as a primary orbital diagnostic technique in 156 patients. A 20-mm syringe, a 22-gauge, 3.75-cm needle, and a plastic pistol grip were used. Local anesthetic was not necessary. When the needle is in the lesion, small to-and-fro movements with a minimum of angulation are helpful. The asp...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77955-3
更新日期：1985-05-15 00:00:00
abstract：PURPOSE:To describe the results of strabismus surgery on three patients with chronic progressive external ophthalmoplegia, a group of rare disorders characterized by ptosis and slowly progressive ophthalmoparesis that has been shown to result from defects in mitochondrial DNA. METHODS:Strabismus surgery using the adju...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71041-4
更新日期：1997-02-01 00:00:00
abstract：PURPOSE:To investigate the effect of cataract surgery on the concentration of moxifloxacin in aqueous and vitreous humor after topical application. DESIGN:Prospective laboratory intervention using a rabbit model. METHODS:Following topical administration of 0.5% moxifloxacin, 60 minutes before surgery and immediately ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.05.011
更新日期：2004-10-01 00:00:00
abstract：:Of 42 patients studied who had fundus flavimaculatus and Stargardt's disease, most had reduced visual acuity due to an atrophic macular lesion. Family histories were consistent with autosomal-recessive inheritance. In some young patients, the yellow-white flecks developed with time, while in some older patients the fl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90539-0
更新日期：1976-10-01 00:00:00
abstract：PURPOSE:To explore the impact of intracameral air tamponade pressure and duration on graft attachment and rebubbling rates. DESIGN:A prospective, interventional, nonrandomized study. METHODS:setting: Department of Ophthalmology, Charité - Universitätsmedizin Berlin. STUDY POPULATION:One hundred seventeen patients wh...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.03.021
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:An association of glaucoma and sleep apnea syndrome (SAS) has been widely reported. We investigated the largest group of patients with SAS thus far to determine the prevalence of glaucoma among these patients. DESIGN:Cross-sectional study. METHODS:An institutional study. STUDY POPULATION:A total of 228 patie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00709-8
更新日期：2003-12-01 00:00:00
