Ethnic differences in the impact of advanced maternal age on birth prevalence of Down syndrome.

Abstract:

OBJECTIVES:This study explored whether ethnic differences in the impact of advanced maternal age on the risk of Down syndrome might reflect differences in use of prenatal diagnostic technologies. METHODS:Maternal age-specific odds of Down syndrome and amniocentesis use were compared among African Americans, Mexican Americans, and non-Hispanic Whites via birth data for the years 1989 to 1991. RESULTS:The odds ratio and population attributable risk of Down syndrome due to maternal age of 35 years or older were highest for Mexican Americans, intermediate for African Americans, and lowest for non-Hispanic Whites. CONCLUSIONS:Advanced maternal age has a greater impact on the risk of Down syndrome for African American and, particularly, Mexican American women than for non-Hispanic White women. This difference in impact might reflect lower availability or use of prenatal diagnostic technologies.

journal_name

Am J Public Health

authors

Khoshnood B,Pryde P,Wall S,Singh J,Mittendorf R,Lee KS

doi

10.2105/ajph.90.11.1778

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

1778-81

issue

11

eissn

0090-0036

issn

1541-0048

journal_volume

90

pub_type

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