Abstract:
:Atherosclerosis and thrombosis may lead to cognitive impairment through cerebral infarcts or white matter hyperintensities. Oxidative stress is now seen as a major contributor to the process of atherogenesis. High intake of polyunsaturated fatty acids, e.g., linoleic acid, or low intake of antioxidants can increase oxidative stress. High intake of n-3 polyunsaturated fatty acids and its main source, fish, may reduce the risk of thrombosis. Little is known, however, about the relation between these dietary factors and cognitive function. The authors investigated this relation with data derived from a cohort of men, aged 69-89 years, who were participants in the Zutphen Elderly Study. The 30-point Mini-Mental State Examination was used to assess cognitive impairment in 1990 (score < or = 25 in 153/476 men, 32%) and cognitive decline from 1990 to 1993 (drop > 2 points in 51/342 men, 15%). Food intake was estimated in 1985 and 1990 by the cross-check dietary history method. High linoleic acid intake was associated with cognitive impairment after adjustment for age, education, cigarette smoking, alcohol consumption, and energy intake (odds ratio (OR) for highest vs. lowest tertile = 1.76, 95% confidence interval (CI) 1.04-3.01). Intake of n-3 polyunsaturated fatty acids was not associated with cognitive impairment, whereas high fish consumption tended to be inversely associated with cognitive impairment (OR = 0.63, 95% CI 0.33-1.21) and cognitive decline (OR = 0.45, 95% CI 0.17-1.16). Intakes of beta-carotene, vitamins C and E, and flavonoids were not inversely associated with cognitive impairment or decline. This study raises the possibility that high linoleic acid intake is positively associated with cognitive impairment and high fish consumption inversely associated with cognitive impairment.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Kalmijn S,Feskens EJ,Launer LJ,Kromhout Ddoi
10.1093/oxfordjournals.aje.a009029subject
Has Abstractpub_date
1997-01-01 00:00:00pages
33-41issue
1eissn
0002-9262issn
1476-6256journal_volume
145pub_type
杂志文章abstract::The determinants of individuals changes in gamma-glutamyltransferase (GGT) were examined in 1,171 males and 1,267 females in Tromsø, Norway, according to a 7-year longitudinal design. The basis for the study was two comprehensive population surveys in 1979-1980 and 1986-1987. In both sexes, increase in GGT displayed a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117075
更新日期:1994-04-15 00:00:00
abstract::Vital statistics data for the United States for the years 1972-1978 have been analyzed for variation in frequency of suicide by month, day of the week, day of the month, and phase of the lunar cycle. Frequency of suicide showed a peak in the spring months, a lesser peak in the fall and was lowest in December. Suicide ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113608
更新日期:1983-06-01 00:00:00
abstract::Since 2005, California law allowed over-the-counter (OTC) syringe sales pending local authorization. Although pharmacy sales of OTC syringes are associated with reduced injection-mediated risks and decreases in human immunodeficiency virus infection rates, little is known about the factors associated with syringe purc...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr492
更新日期:2012-07-01 00:00:00
abstract::This paper illustrates how a microcomputer spreadsheet package can be used by epidemiologists to facilitate the computation of multiple logistic regression (MLR) probabilities, as well as odds ratios and associated confidence intervals, given the coefficients of the MLR model. By formatting a spreadsheet, data entry i...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114150
更新日期:1985-10-01 00:00:00
abstract::Several investigators have observed an association between alcohol consumption and elevated glucose levels, raising the possibility that alcohol may increase the risk of diabetes. This hypothesis was evaluated prospectively among 85,051 women participating in the Nurses' Health Study who were 34 to 59 years of age in ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115002
更新日期:1988-09-01 00:00:00
abstract::Mumps is a potentially severe viral infection. The incidence of mumps has declined dramatically in high-income countries since the introduction of mumps antigen-containing vaccines. However, recent large outbreaks of mumps in highly vaccinated populations suggest waning of vaccine-induced immunity and primary vaccine ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwu014
更新日期:2014-04-15 00:00:00
abstract::Factor analysis has previously identified four independent factors that characterize the insulin resistance syndrome in women, interpreted as 1) weight/waist, 2) lipids, 3) insulin/glucose, and 4) systolic and diastolic blood pressure. Because it is not known whether similar factors emerge for men, or for diabetics, f...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009469
更新日期:1998-03-01 00:00:00
abstract::Senile macular degeneration is a leading cause of visual loss in the United States, England, and probably many other industrialized countries. The clinical manifestations of this disease include: drusen, atrophy of the retinal pigment epithelium, serous detachment of the retinal pigment epithelium, subretinal neovascu...
journal_title:American journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.aje.a113624
更新日期:1983-08-01 00:00:00
abstract::Although type 2 diabetes (T2D) predicts glaucoma, the potential for unmeasured confounding has hampered causal conclusions. We performed separate sample genetic instrumental variable analyses using the Genetic Epidemiology Research Study on Adult Health and Aging cohort (n = 69,685; 1995-2013) to estimate effects of T...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwv204
更新日期:2016-01-15 00:00:00
abstract::The age-specific prevalence of hepatitis A antibodies has been analyzed using a catalytic epidemic model for populations in seven European countries: West Germany, Norway, Greece, Switzerland, Holland, France and Sweden. The results indicate a significant decline in the force of infection in recent decades. However, t...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112790
更新日期:1979-07-01 00:00:00
abstract::Earlier studies report inconsistent associations between education and cognitive aging. We assessed the association, accounting for selective dropout due to death or dementia, and, in a subsample, accounting for confounding by early-life intelligence. Data from the Danish component of the Survey of Health, Ageing and ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwy162
更新日期:2018-11-01 00:00:00
abstract::This report describes the development of hypertension among 1,270 males (aged 23-80 years at the time of entry into the study) observed prospectively for 10 years who had a baseline blood pressure of less than 140/90 mmHg and who underwent baseline spirometry. Subjects were participants in the Normative Aging Study, a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114854
更新日期:1988-04-01 00:00:00
abstract::The observation that Hispanics have lower all-cause and cardiovascular mortality rates despite increased rates of diabetes and obesity and lower socioeconomic status has been termed the "Hispanic paradox." The authors therefore examined the relation between ethnicity and mortality in 1,438 Mexican-American and 921 non...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwg249
更新日期:2003-12-01 00:00:00
abstract::Recent advances in geographic information systems software and multilevel methodology provide opportunities for more extensive characterization of "at-risk" populations in epidemiologic studies. The authors used age-restricted, geocoded data from the all-African-American Jackson Heart Study (JHS), 2000-2004, to demons...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwq317
更新日期:2011-01-01 00:00:00
abstract::As part of the Honolulu Heart Program studies, 4,581 men of Japanese ancestry living in Hawaii completed a psychosocial questionnaire in 1971. By 1980, 280 new cancer cases had been recorded. Among 12 items related to stressful life situations, there were no consistent associations with total or site-specific cancer i...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114027
更新日期:1985-04-01 00:00:00
abstract::There is increased recognition that determinants of health should be investigated in a life-course perspective. Retirement is a major transition in the life course and offers opportunities for changes in physical activity that may improve health in the aging population. The authors examined the effect of retirement on...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm053
更新日期:2007-06-15 00:00:00
abstract::Heavy alcohol drinking is associated with cognitive impairment, but little is known concerning the cognitive effect of moderate alcohol consumption. The Epidemiology of Vascular Aging (EVA) Study is a longitudinal study of cognitive and vascular aging. Between June 1991 and June 1993, 1,389 subjects aged 59-71 years (...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009293
更新日期:1997-09-01 00:00:00
abstract::Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma, its subtypes, and B-cell chronic lymphocytic leukemia (B-CLL) were evaluated in a prospective cohort study of 37,931 Iowa women who were aged 55-69 years at baseline in 1986. Through 1998, 261 cases of non-Hodgkin's lymphoma (137 di...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwf082
更新日期:2002-09-15 00:00:00
abstract::Emergency medical services with advanced life support systems were implemented in the Minneapolis-St. Paul, Minnesota, area in the mid-1970s. To assess the impact of emergency medical services on coronary heart disease mortality, the authors reviewed ambulance records and hospital emergency room logs for possible out-...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116160
更新日期:1991-10-15 00:00:00
abstract::The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also take...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114309
更新日期:1986-05-01 00:00:00
abstract::Long-term exposures to the stress and stimulation of different work, parenting, and partnership combinations might influence later life cognition. We investigated the relationship between women's work-family life histories and cognitive functioning in later life. Analyses were based on data from women born between 193...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwaa042
更新日期:2020-09-01 00:00:00
abstract::Two families of gorillas, comprising 13 animals, were studied in 1980-1982 for hepatitis virus infections. It was found that 27% of them had evidence of hepatitis B infection, and 23% evidence of hepatitis A infection. The four parents had been born in the wild and all of them had been infected with hepatitis B. The t...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113760
更新日期:1984-03-01 00:00:00
abstract::The incidence of non-Hodgkin's lymphoma (NHL) has risen dramatically over the past 50 years. In the search for new risk factors, blood transfusions have been investigated and shown to be associated with subsequent lymphoma in some studies. The authors tested this association in a population-based, case-control study c...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/155.8.725
更新日期:2002-04-15 00:00:00
abstract::Evidence for an association between age-related macular degeneration (AMD) and obesity is inconsistent. The authors examined associations between adiposity and AMD prevalence using 21,287 participants from the Melbourne Collaborative Cohort Study aged 40-69 years at baseline (1990-1994). For men, each increase of 0.1 ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr005
更新日期:2011-06-01 00:00:00
abstract::The authors have investigated the effects of parental smoking patterns on the pulmonary function of children in East Boston, Massachusetts. A crude inverse dose-response relationship was observed between the level of FEF25--75% predicted of children who never smoked and the number of smoking parents in the household. ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112783
更新日期:1979-07-01 00:00:00
abstract::Although erectile dysfunction is frequently seen in patients with manifestations of arteriosclerotic disease, the independent contribution of serum cholesterol in predicting erectile dysfunction is unclear. The aim of this study was to examine the relation between serum cholesterol and erectile dysfunction. Medical hi...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117181
更新日期:1994-11-15 00:00:00
abstract::Plague (infection by Yersinia pestis) was present in Hawaii for the period 1899-1957 and caused at least 370 fatalities. The first infections came from immigrant commensal rats, probably Rattus rattus and Rattus norvegicus, on ships from the Orient. Both species were already established in Hawaii and became the widesp...
journal_title:American journal of epidemiology
pub_type: 历史文章,杂志文章
doi:10.1093/oxfordjournals.aje.a113745
更新日期:1984-02-01 00:00:00
abstract::Cancer is an important cause of morbidity in the elderly, and many medical conditions and treatments influence cancer risk. The Surveillance, Epidemiology, and End Results (SEER)-Medicare database can be used to conduct population-based case-control studies that elucidate the etiology of cancer among the US elderly. S...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr146
更新日期:2011-10-01 00:00:00
abstract::We used full-system-estimation instrumental-variables simultaneous equations modeling (IV-SEM) to examine physical activity relative to body mass index (BMI; weight (kg)/height (m)(2)) using 25 years of data (1985/1986 to 2010/2011) from the Coronary Artery Risk Development in Young Adults (CARDIA) Study (n = 5,115; a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kww010
更新日期:2016-09-15 00:00:00
abstract::The possibility that hepatitis B is transmitted venereally was examined by determining the prevalence of hepatitis B antibody (anti-HB(S)) in populations with different levels of promiscuity. Of 258 prostitutes, 31% were anti-HB(S) positive, compared to 10% of 258 female age-matched blood donors, 10% of 48 nuns living...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112153
更新日期:1975-09-01 00:00:00