Herpes simplex type 2 causing fulminant hepatic failure.

Abstract:

:Although exceedingly rare, fulminant hepatic failure (FHF) in immunocompetent patients can develop with primary or recurrent infection due to herpes simplex virus (HSV). The diagnosis is frequently obscured by the absence of mucocutaneous involvement. Elevated transaminase values with leukopenia and a relatively low bilirubin level may provide clues to the diagnosis. We describe an immunocompetent woman who died of FHF before a definitive diagnosis of HSV type 2 hepatitis was established. Herpes simplex virus hepatitis is one of the few causes of FHF for which potentially effective therapy is available. Thus, early diagnosis is paramount and usually requires liver biopsy. Recent studies suggest that transjugular liver biopsy is safe and effective in establishing the cause of FHF. Since the diagnosis and management of FHF are frequently influenced by the results of transjugular liver biopsy, it may become a standard diagnostic tool for managing FHF in centers where such expertise exists.

journal_name

South Med J

journal_title

Southern medical journal

authors

Fahy RJ,Crouser E,Pacht ER

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

1212-6

issue

12

eissn

0038-4348

issn

1541-8243

journal_volume

93

pub_type

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