Neurophysiologic evaluation of cyclosporine toxicity associated with bone marrow transplantation.

Abstract:

INTRODUCTION:Cortical blindness, a rare form of cyclosporine (CSA) neurotoxicity, has previously been described in only nine bone marrow transplant (BMT) recipients. METHODS:Our institution averages 35 allogeneic BMT's per year. In the past year we have seen two women with reversible cortical blindness secondary to CSA toxicity. RESULTS:Age (years) (Case 1; Case 2): 32; 22. Day post-BMT: 41; 50. Peak CSA level (ng/ml): 1159; 632. Both had a history of renal toxicity requiring adjustment of CSA dosage. MRI - both with diffuse while matter changes. EEG - both with moderate to severe generalized slowing. Visual evoked potentials were markedly prolonged in both. Auditory evoked potentials: minimally abnormal; normal. Somatosensory evoked potentials - both normal. Prompt improvement occurred with discontinuation of CSA. Followup neurophysiologic evaluations were normal, however structural changes remained on MRI. CONCLUSION:As neurophysiologic studies closely follow the clinical status they should be included in the evaluation and followup of CSA neurotoxicity.

journal_name

Acta Neurol Scand

authors

Edwards LL,Wszolek ZK,Normand MM

doi

10.1111/j.1600-0404.1996.tb07081.x

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

358-64

issue

5

eissn

0001-6314

issn

1600-0404

journal_volume

94

pub_type

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